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Entry version 151 (17 Jun 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Protein spinster

Gene

spin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable sphingolipid transporter that plays a central role in endosomes and/or lysosomes storage. Involved in TGF-beta-mediated synaptic growth regulation both pre- and postsynaptically via its function in endosomal storage regulation. Also required during oogenesis by regulating yolk spheres storage.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Lipid transport, Oogenesis, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.49.1 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein spinster
Alternative name(s):
Protein benchwarmer
Protein diphthong
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:spin
Synonyms:bnch
ORF Names:CG8428
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0086676 spin

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei115 – 137HelicalSequence analysisAdd BLAST23
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Transmembranei558 – 578HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

In most cases, death at the late pupal stage, probably due to lipid accumulation in endosomes/lysosomes. Some flies survive until adulthood and display a strong rejection behavior of female flies in response to male courtship accompanied by decreases in the viability, adult life span, and oviposition rate of the flies. Some oocytes and adult neural cells undergo degeneration, which is preceded by reductions in programmed cell death of nurse cells in ovaries and of neurons in the pupal nervous system, respectively. The central nervous system (CNS) of flies accumulates lipopigments. Flies also display a strong synaptic overgrowth: synapses reveal a strong increase in bouton number and a deficit in presynaptic release caused by enhanced/misregulated TGF-beta signaling. A widespread accumulation of enlarged lysosomal and late endosomal inclusions is also present in yolk spheres during oogenesis.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi217E → K in bnch(N); leads to storage in yolk spheres during oogenesis and results in widespread accumulation of enlarged lysosomal and late endosomal inclusions. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003639551 – 605Protein spinsterAdd BLAST605

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi583N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GQQ0

PRoteomics IDEntifications database

More...
PRIDEi
Q9GQQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Enriched in brain (at protein level).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in both motoneurons and muscle throughout the period of synaptic growth and development at the neuromuscular junction. Expressed throughout the CNS, including motoneurons. Weak expression is observed in embryonic muscle as well as other tissues. Expressed throughout the larval CNS with pronounced expression in motoneurons. Also strongly expressed in all body wall muscle as well as other tissues, including a subset of epithelial cells and the salivary glands.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0086676 Expressed in embryonic/larval hemocyte (Drosophila) and 25 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9GQQ0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9GQQ0 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
69637, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q9GQQ0, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0088549

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1330 Eukaryota
COG0477 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005976

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001265_5_12_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9GQQ0

KEGG Orthology (KO)

More...
KOi
K23677

Identification of Orthologs from Complete Genome Data

More...
OMAi
LANNWRW

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9GQQ0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690 MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: Q9GQQ0-1) [UniParc]FASTAAdd to basket
Also known as: Type IV

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLKHQKQSY QPLPTAAAMD NPAMIQSSGS SGSSSSEEGG SREDVANLSP
60 70 80 90 100
LGLPTTYSSQ QLMPSDTDSM EEERHRLRPH HHHHHPLGEH HHIPGIPPSA
110 120 130 140 150
VVPSRLSSVG RSQWFTVTVL CFVNLINYMD RFTIAGVLTD VRNDFDIGND
160 170 180 190 200
SAGLLQTVFV ISYMVCAPIF GYLGDRYSRP WIMAVGVGLW STTTLLGSFM
210 220 230 240 250
KQFGWFIAFR ALVGIGEASY STIAPTIISD LFVHDMRSKM LALFYFAIPV
260 270 280 290 300
GSGLGYIVGS KTAHLANDWR WALRVTPILG IVAVFLILLI KDPVRGHSEG
310 320 330 340 350
SHNLEATTYK QDIKALVRNR SFMLSTAGFT CVAFVAGALA WWGPSFIYLG
360 370 380 390 400
MKMQPGNENI VQDDVAFNFG VITMLAGLLG VPLGSFLSQY LVKRYPTADP
410 420 430 440 450
VICAFGLLVS APLLTGACLL VNSNSVGTYA LIFFGQLALN LNWAIVADIL
460 470 480 490 500
LYVVVPTRRS TAEAFQILIS HALGDAGSPY LVGAISEAIM KHLHKNPSDS
510 520 530 540 550
GLTTELRSMS QVAGSAISNA TQVIAEATTS LMETARSSAS QEYSDVEQFE
560 570 580 590 600
GLQYALFSTS FVEVLGGIFF IFTACFIIKD KYNATRGLQD ATAQQQQRDE

RGQIA
Length:605
Mass (Da):65,820
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD79951AEDE20F5C8
GO
Isoform B (identifier: Q9GQQ0-2) [UniParc]FASTAAdd to basket
Also known as: Type I

The sequence of this isoform differs from the canonical sequence as follows:
     365-444: VAFNFGVITM...GQLALNLNWA → ISYKFGLVAM...AQVALNLCWS
     590-605: DATAQQQQRDERGQIA → GDQGAQAVRSSVALASGQKDVESFNSDCLVLCTDIALRERT

Show »
Length:630
Mass (Da):68,621
Checksum:i439731163275B791
GO
Isoform C (identifier: Q9GQQ0-3) [UniParc]FASTAAdd to basket
Also known as: Type III

The sequence of this isoform differs from the canonical sequence as follows:
     365-444: VAFNFGVITM...GQLALNLNWA → ISYKFGLVAM...AQVALNLCWS

Show »
Length:605
Mass (Da):66,124
Checksum:iBA271BAC51BFF31C
GO
Isoform D (identifier: Q9GQQ0-4) [UniParc]FASTAAdd to basket
Also known as: Type II

The sequence of this isoform differs from the canonical sequence as follows:
     590-605: DATAQQQQRDERGQIA → GDQGAQAVRSSVALASGQKDVESFNSDCLVLCTDIALRERT

Show »
Length:630
Mass (Da):68,316
Checksum:i95F9BB3C2045CF91
GO
Isoform E (identifier: Q9GQQ0-5) [UniParc]FASTAAdd to basket
Also known as: Type V

The sequence of this isoform differs from the canonical sequence as follows:
     365-605: VAFNFGVITM...QQRDERGQIA → MWWFPRDVQQ...IWLEQSPRPS

Show »
Length:402
Mass (Da):44,547
Checksum:i315303D8C7492FC3
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK93216 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform E (identifier: Q9GQQ0-5)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti389P → Q in AAG43829 (PubMed:11340170).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036366365 – 605VAFNF…RGQIA → MWWFPRDVQQPRPSKSSSHT HSVMPAVRIWLEQSPRPS in isoform E. 1 PublicationAdd BLAST241
Alternative sequenceiVSP_036367365 – 444VAFNF…NLNWA → ISYKFGLVAMLAGLIGVPLG SFLAQRLRGRYENCDPYICA VGLFISAPMVFAALVVPQTS ESLCFFFVFVAQVALNLCWS in isoform B and isoform C. 2 PublicationsAdd BLAST80
Alternative sequenceiVSP_036368590 – 605DATAQ…RGQIA → GDQGAQAVRSSVALASGQKD VESFNSDCLVLCTDIALRER T in isoform B and isoform D. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF212366 mRNA Translation: AAG43825.1
AF212367 mRNA Translation: AAG43826.1
AF212368 mRNA Translation: AAG43827.1
AF212369 mRNA Translation: AAG43828.1
AF212370 mRNA Translation: AAG43829.1
AE013599 Genomic DNA Translation: AAF58060.2
AE013599 Genomic DNA Translation: AAM70950.1
AE013599 Genomic DNA Translation: AAM70951.1
AE013599 Genomic DNA Translation: AAM70952.1
AE013599 Genomic DNA Translation: AAM70953.1
BT032842 mRNA Translation: ACD81856.1
AY051792 mRNA Translation: AAK93216.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_524823.1, NM_080084.3 [Q9GQQ0-4]
NP_725530.1, NM_166144.2 [Q9GQQ0-3]
NP_725531.1, NM_166145.2 [Q9GQQ0-1]
NP_725532.1, NM_166146.2 [Q9GQQ0-2]
NP_725533.1, NM_166147.2 [Q9GQQ0-5]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089589; FBpp0088548; FBgn0086676 [Q9GQQ0-5]
FBtr0089590; FBpp0088549; FBgn0086676 [Q9GQQ0-4]
FBtr0089591; FBpp0088550; FBgn0086676 [Q9GQQ0-3]
FBtr0089592; FBpp0088551; FBgn0086676 [Q9GQQ0-2]
FBtr0089593; FBpp0088552; FBgn0086676 [Q9GQQ0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
45380

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8428

UCSC genome browser

More...
UCSCi
CG8428-RA d. melanogaster [Q9GQQ0-1]
CG8428-RB d. melanogaster
CG8428-RC d. melanogaster
CG8428-RD d. melanogaster
CG8428-RE d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212366 mRNA Translation: AAG43825.1
AF212367 mRNA Translation: AAG43826.1
AF212368 mRNA Translation: AAG43827.1
AF212369 mRNA Translation: AAG43828.1
AF212370 mRNA Translation: AAG43829.1
AE013599 Genomic DNA Translation: AAF58060.2
AE013599 Genomic DNA Translation: AAM70950.1
AE013599 Genomic DNA Translation: AAM70951.1
AE013599 Genomic DNA Translation: AAM70952.1
AE013599 Genomic DNA Translation: AAM70953.1
BT032842 mRNA Translation: ACD81856.1
AY051792 mRNA Translation: AAK93216.1 Different initiation.
RefSeqiNP_524823.1, NM_080084.3 [Q9GQQ0-4]
NP_725530.1, NM_166144.2 [Q9GQQ0-3]
NP_725531.1, NM_166145.2 [Q9GQQ0-1]
NP_725532.1, NM_166146.2 [Q9GQQ0-2]
NP_725533.1, NM_166147.2 [Q9GQQ0-5]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi69637, 11 interactors
IntActiQ9GQQ0, 5 interactors
STRINGi7227.FBpp0088549

Protein family/group databases

TCDBi2.A.1.49.1 the major facilitator superfamily (mfs)

Proteomic databases

PaxDbiQ9GQQ0
PRIDEiQ9GQQ0

Genome annotation databases

EnsemblMetazoaiFBtr0089589; FBpp0088548; FBgn0086676 [Q9GQQ0-5]
FBtr0089590; FBpp0088549; FBgn0086676 [Q9GQQ0-4]
FBtr0089591; FBpp0088550; FBgn0086676 [Q9GQQ0-3]
FBtr0089592; FBpp0088551; FBgn0086676 [Q9GQQ0-2]
FBtr0089593; FBpp0088552; FBgn0086676 [Q9GQQ0-1]
GeneIDi45380
KEGGidme:Dmel_CG8428
UCSCiCG8428-RA d. melanogaster [Q9GQQ0-1]
CG8428-RB d. melanogaster
CG8428-RC d. melanogaster
CG8428-RD d. melanogaster
CG8428-RE d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
45380
FlyBaseiFBgn0086676 spin

Phylogenomic databases

eggNOGiKOG1330 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00390000005976
HOGENOMiCLU_001265_5_12_1
InParanoidiQ9GQQ0
KOiK23677
OMAiLANNWRW
PhylomeDBiQ9GQQ0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
45380 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
45380

Protein Ontology

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PROi
PR:Q9GQQ0

Gene expression databases

BgeeiFBgn0086676 Expressed in embryonic/larval hemocyte (Drosophila) and 25 other tissues
ExpressionAtlasiQ9GQQ0 baseline and differential
GenevisibleiQ9GQQ0 DM

Family and domain databases

InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPIN_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GQQ0
Secondary accession number(s): A1ZAA4
, Q960X6, Q9GQP9, Q9GQQ1, Q9GQQ2, Q9GQQ3, Q9V7J3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 1, 2001
Last modified: June 17, 2020
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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