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UniProtKB - Q9GQ82 (Q9GQ82_DROME)
Protein
Submitted name:
Aspartyl beta-hydroxylase variant 1
Gene
Asph
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- peptidyl-aspartic acid 3-dioxygenase activity Source: UniProtKB-EC
GO - Biological processi
- peptidyl-aspartic acid hydroxylation Source: InterPro
Keywordsi
Molecular function | OxidoreductaseImported |
Names & Taxonomyi
Protein namesi | Submitted name: Aspartyl beta-hydroxylase variant 1ImportedSubmitted name: Aspartyl beta-hydroxylase, isoform AImported (EC:1.14.11.16Imported) |
Gene namesi | ORF Names:CG8421Imported, Dmel_CG8421Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0034075, Asph |
VEuPathDBi | VectorBase:FBgn0034075 |
Subcellular locationi
Other locations
- endomembrane system Source: FlyBase
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 54 – 72 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | FBgn0034075, Expressed in adult organism and 43 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 620 – 772 | Asp_Arg_HydroxInterPro annotationAdd BLAST | 153 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 101 – 364 | DisorderedSequence analysisAdd BLAST | 264 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 101 – 123 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 124 – 199 | Acidic residuesSequence analysisAdd BLAST | 76 | |
Compositional biasi | 212 – 231 | Acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 242 – 261 | Acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 279 – 307 | Acidic residuesSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the aspartyl/asparaginyl beta-hydroxylase family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000172466 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit 2.60.120.330, 1 hit |
InterProi | View protein in InterPro IPR007803, Asp/Arg/Pro-Hydrxlase IPR039038, ASPH IPR027443, IPNS-like_sf IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR12366, PTHR12366, 1 hit |
Pfami | View protein in Pfam PF05118, Asp_Arg_Hydrox, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q9GQ82-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGDVQPRKR KDKRRKRDDD ESSHGVHITK MGNEDLHLHV HHDHGTGGHW
60 70 80 90 100
CAKIIFFALM AVLLGLVGLI IMENRGLEDL DTPLSESRFS KVFDGWVDEH
110 120 130 140 150
RDEHDGHDVQ EPSGEALDDH DEHDDHDDHE DEDEEPLTEE LEEELEEEEE
160 170 180 190 200
PTEEDEPAAD EEYEEDEDEE NNAGENITAE DAEEEEEEED NDDEGTVEAT
210 220 230 240 250
VEATTEATTE ATGEYEAEED DEDEAAADDD AVESTEAPLS KAEEQEDDED
260 270 280 290 300
EDEEEQEIEE SVEPERSQYA AQSAPAKDNN DDDDDDDQDK NDADDGDDDE
310 320 330 340 350
FESLAQQFEN DPEDTVPAKA VESEEQDQDQ ADEEEPKEEG SSWLASQIKP
360 370 380 390 400
KEAAPAPAEK EDPFEQELRK ANEEMIRENY AQALRSFNTL TTNFAHEPSA
410 420 430 440 450
HLGRARLLEL LAKKERSNQR LWEAIDAYKR YLAFGELVAS NQEFQTAGES
460 470 480 490 500
CIENLRFLGH HRQATTIHEL LINRLPEDPR LRNQLSLTYL MVNNLQQVEK
510 520 530 540 550
VAVETLKLWP NNAVAQLHYG LALRQFHADY AKALPYLKYA VESGEEGTQE
560 570 580 590 600
AFFYLSLGET MQRLSMKSEA LEVYGKGVAK GFFASLYQRS LYNEPRLRAQ
610 620 630 640 650
PFWQPKETGY ERQLEKLTLN WRAIRDEGLA LLGRSGFFED EAELLRDKGV
660 670 680 690 700
WQQYELYAQG RRVKDNCRRA PITCSLLEEF PESAGCRRGQ VKFSVMQAKT
710 720 730 740 750
HVWPHCGPTN CRLRAHLTLA APEPEKASLR VAEQERTWRE GELFIFDDSF
760 770 780
EHEVWHNGSQ SRLVLILDMW HPQLSAAQRR SLSPI
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4KFS5 | A0A0B4KFS5_DROME | Aspartyl beta-hydroxylase, isoform ... | Asph BAH, CG18658, Dmel\CG8421, humbug, CG8421 | 991 | Annotation score: | ||
A0A0B4K7C1 | A0A0B4K7C1_DROME | Aspartyl beta-hydroxylase, isoform ... | Asph BAH, CG18658, Dmel\CG8421, humbug, CG8421 | 803 | Annotation score: | ||
D1Z397 | D1Z397_DROME | Aspartyl beta-hydroxylase, isoform ... | Asph Asph-RB, BAH, CG18658, Dmel\CG8421, humbug | 400 | Annotation score: | ||
A4UZJ1 | A4UZJ1_DROME | Aspartyl beta-hydroxylase, isoform ... | Asph BAH, CG18658, Dmel\CG8421, humbug, CG8421 | 557 | Annotation score: | ||
A0A0B4J402 | A0A0B4J402_DROME | Aspartyl beta-hydroxylase, isoform ... | Asph BAH, CG18658, Dmel\CG8421, humbug, CG8421 | 556 | Annotation score: | ||
A0A0B4K884 | A0A0B4K884_DROME | Aspartyl beta-hydroxylase, isoform ... | Asph BAH, CG18658, Dmel\CG8421, humbug, CG8421 | 575 | Annotation score: | ||
Q7KHE2 | Q7KHE2_DROME | Aspartyl beta-hydroxylase variant 2 | Asph BAH, CG18658, Dmel\CG8421, humbug, CG8421 | 382 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF289493 mRNA Translation: AAG40806.1 AE013599 Genomic DNA Translation: AAM70947.1 |
RefSeqi | NP_725525.1, NM_166140.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0087220; FBpp0086359; FBgn0034075 |
GeneIDi | 36778 |
UCSCi | CG8421-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF289493 mRNA Translation: AAG40806.1 AE013599 Genomic DNA Translation: AAM70947.1 |
RefSeqi | NP_725525.1, NM_166140.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 36778 |
Genome annotation databases
EnsemblMetazoai | FBtr0087220; FBpp0086359; FBgn0034075 |
GeneIDi | 36778 |
UCSCi | CG8421-RA, d. melanogaster |
Organism-specific databases
CTDi | 444 |
FlyBasei | FBgn0034075, Asph |
VEuPathDBi | VectorBase:FBgn0034075 |
Phylogenomic databases
GeneTreei | ENSGT00940000172466 |
Miscellaneous databases
BioGRID-ORCSi | 36778, 0 hits in 3 CRISPR screens |
ChiTaRSi | Asph, fly |
GenomeRNAii | 36778 |
Gene expression databases
Bgeei | FBgn0034075, Expressed in adult organism and 43 other tissues |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit 2.60.120.330, 1 hit |
InterProi | View protein in InterPro IPR007803, Asp/Arg/Pro-Hydrxlase IPR039038, ASPH IPR027443, IPNS-like_sf IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR12366, PTHR12366, 1 hit |
Pfami | View protein in Pfam PF05118, Asp_Arg_Hydrox, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9GQ82_DROME | |
Accessioni | Q9GQ82Primary (citable) accession number: Q9GQ82 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | January 19, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |