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Protein

Fructose-bisphosphate aldolase

Gene

FBPA

Organism
Echinococcus multilocularis (Fox tapeworm)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (PGI)
  3. ATP-dependent 6-phosphofructokinase (EmuJ_001128600)
  4. Fructose-bisphosphate aldolase (FBPA), Fructose-bisphosphate aldolase (EmuJ_000993800), Fructose-bisphosphate aldolase (EmuJ_000993700), Fructose-bisphosphate aldolase (EmuJ_000905600)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56SubstrateBy similarity1
Binding sitei147SubstrateBy similarity1
Active sitei188Proton acceptorBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei363Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Gene namesi
Name:FBPA
OrganismiEchinococcus multilocularis (Fox tapeworm)
Taxonomic identifieri6211 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesCestodaEucestodaCyclophyllideaTaeniidaeEchinococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002169331 – 363Fructose-bisphosphate aldolaseAdd BLAST363

Proteomic databases

PRIDEiQ9GP32

Structurei

3D structure databases

ProteinModelPortaliQ9GP32
SMRiQ9GP32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9GP32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRFVPYLCA EKMKELRENA SAIVAPGKGL LAADESTNTI GKRFAAINLE
60 70 80 90 100
NTEENRRAYR ELLFTTDPEF AKHISGVILF HETVYQKTKD GKPFVELLRE
110 120 130 140 150
RGVLPGIKVD LGVVPLGGTA DECTTQGLDN LAQRCAQYYN DGCRFAKWRC
160 170 180 190 200
VLKISSHNPS YLAMLENANV LARYAFICQQ NGLVPIVEPE VLPDGDHDLE
210 220 230 240 250
TAQRVTEQVL SFVYKALADH HVYLEGTLLK PNMVTCGQSC TKKYSVEDNA
260 270 280 290 300
RATVEALQRT VPVAVPGVVF LSGGQSELDA TRNLNAINKY PGKKPWALSF
310 320 330 340 350
SFGRALQASA IAAWQGKPEN VKAGQAEFLQ LAKANGAASL GKFEGELKTA
360
AGQKSLFVAN HAY
Length:363
Mass (Da):39,727
Last modified:March 1, 2001 - v1
Checksum:i37862DEC55BA2B70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ292376 mRNA Translation: CAC18550.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ292376 mRNA Translation: CAC18550.1

3D structure databases

ProteinModelPortaliQ9GP32
SMRiQ9GP32
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9GP32

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALF_ECHMU
AccessioniPrimary (citable) accession number: Q9GP32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2001
Last modified: March 15, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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