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Entry version 169 (02 Jun 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Peptidoglycan-recognition protein LC

Gene

PGRP-LC

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response (PubMed:11872802, PubMed:22022271).

Required for Relish processing and nuclear translocation following proteolytic cleavage (PubMed:11872802).

Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria (PubMed:11872802).

The different isoforms probably display different recognition capabilities to various microbial patterns (PubMed:12777387, PubMed:16006509).

4 Publications

Mediates the response to LPS and Gram-negative bacteria.

2 Publications

Mediates the response to LPS, peptidoglycan and Gram-negative bacteria.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-209171, Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE [Q9GNK5-2]
R-DME-209266, Peptidoglycan bound PGRP-LC/LE oligomerises
R-DME-214397, Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214399, Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214411, REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214416, Phosphorylated REL is cleaved by and dissociates from DREDD
R-DME-6803157, Antimicrobial peptides [Q9GNK5-2]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidoglycan-recognition protein LC
Alternative name(s):
Immune response deficient 7 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PGRP-LC
Synonyms:ird7, PGRPLC
ORF Names:CG4432
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0035976, PGRP-LC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 291CytoplasmicSequence analysisAdd BLAST291
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei292 – 312Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini313 – 520ExtracellularSequence analysisAdd BLAST208

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Larvae infected with Gram-negative bacteria fail to induce tracheal expression of the antimicrobial peptide gene Drs.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002206241 – 520Peptidoglycan-recognition protein LCAdd BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi389N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi390 ↔ 3962 Publications
Glycosylationi515N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GNK5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9GNK5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the fat body and hemocytes.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during larval and pupal stages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0035976, Expressed in saliva-secreting gland and 35 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9GNK5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9GNK5, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
64460, 89 interactors

Protein interaction database and analysis system

More...
IntActi
Q9GNK5, 3 interactors

Molecular INTeraction database

More...
MINTi
Q9GNK5

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0088492

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1520
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9GNK5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9GNK5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini412 – 490N-acetylmuramoyl-L-alanine amidaseSequence analysisAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 78DisorderedSequence analysisAdd BLAST78
Regioni239 – 278DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 40Polar residuesSequence analysisAdd BLAST40
Compositional biasi47 – 77Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi255 – 270Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502S2KY, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9GNK5

Identification of Orthologs from Complete Genome Data

More...
OMAi
TEMSQCP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9GNK5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06583, PGRP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.80.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036505, Amidase/PGRP_sf
IPR002502, Amidase_domain
IPR015510, PGRP
IPR006619, PGRP_domain_met/bac

The PANTHER Classification System

More...
PANTHERi
PTHR11022, PTHR11022, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01510, Amidase_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00701, PGRP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55846, SSF55846, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform a1 Publication (identifier: Q9GNK5-1) [UniParc]FASTAAdd to basket
Also known as: B1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPFSNETEMS QCSNAKRRVN DPLTGPKNCS TSSTDSGVIL NDNVAAFRPE
60 70 80 90 100
KETKDRGTGE GQFQSKSEEK TESKRISVEH TVNITTENVG KTSSPAVSIR
110 120 130 140 150
STTISVVSID DNAIDSSSID SDSEAEAEDY TVQKLGHQVT YPPNSSHLRD
160 170 180 190 200
LNQGLTVISR HVAPGEAAVP PPNPLEAGIV AKQILNGNLA VATPTSPAGG
210 220 230 240 250
ATQGIGSIAL TNSTDVTFGD KHFYEGPVTI QQFLIDNRDK WKPGEGPAGG
260 270 280 290 300
QDNPAFNGGP STNGSAPGSK HEDPAQTPPI CPFLPNTVGR KAVTVTVVFV
310 320 330 340 350
TLTFLLGIVL ATTTNLFGKT LNQSKIRDDD DYRQNIPINS TIDLDNIGGG
360 370 380 390 400
LILRFVERQQ WLAQPPQKEI PDLELPVGLV IALPTNSENC STQAICVLRV
410 420 430 440 450
RLLQTYDIES SQKCDIAYNF LIGGDGNVYV GRGWNKMGAH MNNINYDSQS
460 470 480 490 500
LSFAYIGSFK TIQPSAKQLS VTRLLLERGV KLGKIAPSYR FTASSKLMPS
510 520
VTDFKADALY ASFANWTHWS
Length:520
Mass (Da):56,046
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3215F8380857DFC1
GO
Isoform x1 Publication (identifier: Q9GNK5-2) [UniParc]FASTAAdd to basket
Also known as: A1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     324-520: SKIRDDDDYR...ASFANWTHWS → TDLDVIDNST...KKWPHWSHEI

Show »
Length:500
Mass (Da):54,094
Checksum:iA0459DE723A8C720
GO
Isoform y1 Publication (identifier: Q9GNK5-3) [UniParc]FASTAAdd to basket
Also known as: C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     324-520: SKIRDDDDYR...ASFANWTHWS → TNDPEIHVDG...KTWPDLHMTQ

Show »
Length:511
Mass (Da):55,545
Checksum:i0969EE0AF556F549
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9NDN2M9NDN2_DROME
Peptidoglycan recognition protein L...
PGRP-LC (PGRP)-LC, Dm PGRP-LC, Dmel\CG4432, ird7, pgrp lc
520Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JI88E1JI88_DROME
Peptidoglycan recognition protein L...
PGRP-LC (PGRP)-LC, Dm PGRP-LC, Dmel\CG4432, ird7, pgrp lc
500Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0S0WMR4A0A0S0WMR4_DROME
Peptidoglycan recognition protein L...
PGRP-LC (PGRP)-LC, Dm PGRP-LC, Dmel\CG4432, ird7, pgrp lc
501Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JI89E1JI89_DROME
Peptidoglycan recognition protein L...
PGRP-LC (PGRP)-LC, Dm PGRP-LC, Dmel\CG4432, ird7, pgrp lc
329Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U8U0I3A0A2U8U0I3_DROME
Peptidoglycan recognition protein L...
PGRP-LC (PGRP)-LC, Dm PGRP-LC, Dmel\CG4432, ird7, pgrp lc
340Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U8U141A0A2U8U141_DROME
Peptidoglycan recognition protein L...
PGRP-LC (PGRP)-LC, Dm PGRP-LC, Dmel\CG4432, ird7, pgrp lc
330Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JI87E1JI87_DROME
Peptidoglycan recognition protein L...
PGRP-LC (PGRP)-LC, Dm PGRP-LC, Dmel\CG4432, ird7, pgrp lc
345Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform y1 Publication (identifier: Q9GNK5-3)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti338I → V in AAS65052 (PubMed:10731132).Curated1
Sequence conflicti355L → F in AAS65052 (PubMed:10731132).Curated1
Sequence conflicti373T → K in AAQ16306 (PubMed:12777387).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050759324 – 520SKIRD…WTHWS → TDLDVIDNSTLVILKVAEWG GRPAKRMLDAQQLPINRVVI SHTAAEGCESREVCSARVNV VQSFHMDSWGWDHIGYNFLV GGDGRVYEGRGWDYVGAHTK GYNRGSIGISFIGTFTTRKP NERQLEACQLLLQEGVRLKK LTTNYRLYGHRQLSATESPG EELYKIIKKWPHWSHEI in isoform x. 4 PublicationsAdd BLAST197
Alternative sequenceiVSP_050760324 – 520SKIRD…WTHWS → TNDPEIHVDGKLVVISIKGW GGMPTRGNLKPLKLPVSKVI ISETPPEICTTQDSCSYWTR VTQSRHMDTFNWSQVGYNFL VGGDGRIYEGRGWNYMGDHT RDNNNNSIGITFLGTFRRQE PTPKSLEACQLLIAQGVRLK KLKPDYQLLGHRQITGTLMP GEELYRIIQTWNNWYNLTKT WPDLHMTQ in isoform y. 2 PublicationsAdd BLAST197

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF207539 mRNA Translation: AAG23733.1
AF500096 mRNA Translation: AAM18530.1
AY327466 mRNA Translation: AAQ16306.1
AE014296 Genomic DNA Translation: AAF50302.3
AE014296 Genomic DNA Translation: AAN11957.1
AE014296 Genomic DNA Translation: AAS65052.1
AY119048 mRNA Translation: AAM50908.1
BT025958 mRNA Translation: ABG02202.1

NCBI Reference Sequences

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RefSeqi
NP_001163396.1, NM_001169925.1 [Q9GNK5-2]
NP_001246693.1, NM_001259764.1 [Q9GNK5-1]
NP_648298.1, NM_140041.4 [Q9GNK5-1]
NP_729468.2, NM_168324.4 [Q9GNK5-2]
NP_996030.1, NM_206308.4

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0089490; FBpp0088491; FBgn0035976 [Q9GNK5-2]
FBtr0089491; FBpp0088492; FBgn0035976 [Q9GNK5-1]
FBtr0300290; FBpp0289518; FBgn0035976 [Q9GNK5-2]
FBtr0308349; FBpp0300668; FBgn0035976 [Q9GNK5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
39063

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG4432

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207539 mRNA Translation: AAG23733.1
AF500096 mRNA Translation: AAM18530.1
AY327466 mRNA Translation: AAQ16306.1
AE014296 Genomic DNA Translation: AAF50302.3
AE014296 Genomic DNA Translation: AAN11957.1
AE014296 Genomic DNA Translation: AAS65052.1
AY119048 mRNA Translation: AAM50908.1
BT025958 mRNA Translation: ABG02202.1
RefSeqiNP_001163396.1, NM_001169925.1 [Q9GNK5-2]
NP_001246693.1, NM_001259764.1 [Q9GNK5-1]
NP_648298.1, NM_140041.4 [Q9GNK5-1]
NP_729468.2, NM_168324.4 [Q9GNK5-2]
NP_996030.1, NM_206308.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z6IX-ray2.50A355-520[»]
2F2LX-ray2.10A355-520[»]
X418-434[»]
SMRiQ9GNK5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi64460, 89 interactors
IntActiQ9GNK5, 3 interactors
MINTiQ9GNK5
STRINGi7227.FBpp0088492

PTM databases

iPTMnetiQ9GNK5

Proteomic databases

PaxDbiQ9GNK5

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
39063

Genome annotation databases

EnsemblMetazoaiFBtr0089490; FBpp0088491; FBgn0035976 [Q9GNK5-2]
FBtr0089491; FBpp0088492; FBgn0035976 [Q9GNK5-1]
FBtr0300290; FBpp0289518; FBgn0035976 [Q9GNK5-2]
FBtr0308349; FBpp0300668; FBgn0035976 [Q9GNK5-1]
GeneIDi39063
KEGGidme:Dmel_CG4432

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
39063
FlyBaseiFBgn0035976, PGRP-LC

Phylogenomic databases

eggNOGiENOG502S2KY, Eukaryota
InParanoidiQ9GNK5
OMAiTEMSQCP
PhylomeDBiQ9GNK5

Enzyme and pathway databases

ReactomeiR-DME-209171, Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE [Q9GNK5-2]
R-DME-209266, Peptidoglycan bound PGRP-LC/LE oligomerises
R-DME-214397, Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214399, Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214411, REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'
R-DME-214416, Phosphorylated REL is cleaved by and dissociates from DREDD
R-DME-6803157, Antimicrobial peptides [Q9GNK5-2]

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
39063, 0 hits in 3 CRISPR screens
EvolutionaryTraceiQ9GNK5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
39063

Protein Ontology

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PROi
PR:Q9GNK5

Gene expression databases

BgeeiFBgn0035976, Expressed in saliva-secreting gland and 35 other tissues
ExpressionAtlasiQ9GNK5, baseline and differential
GenevisibleiQ9GNK5, DM

Family and domain databases

CDDicd06583, PGRP, 1 hit
Gene3Di3.40.80.10, 1 hit
InterProiView protein in InterPro
IPR036505, Amidase/PGRP_sf
IPR002502, Amidase_domain
IPR015510, PGRP
IPR006619, PGRP_domain_met/bac
PANTHERiPTHR11022, PTHR11022, 1 hit
PfamiView protein in Pfam
PF01510, Amidase_2, 1 hit
SMARTiView protein in SMART
SM00701, PGRP, 1 hit
SUPFAMiSSF55846, SSF55846, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGPLC_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GNK5
Secondary accession number(s): Q1EBX6
, Q7YW58, Q8T5Q2, Q9VSV9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2001
Last modified: June 2, 2021
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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