Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Estradiol 17-beta-dehydrogenase 8

Gene

HSD17B8

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD.By similarity

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.By similarity
Testosterone + NAD+ = androstenedione + NADH.By similarity

Pathwayi: estrogen biosynthesis

This protein is involved in the pathway estrogen biosynthesis, which is part of Steroid biosynthesis.By similarity
View all proteins of this organism that are known to be involved in the pathway estrogen biosynthesis and in Steroid biosynthesis.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38SubstrateBy similarity1
Active sitei51Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 55NADBy similarity5
Nucleotide bindingi84 – 86NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNAD

Enzyme and pathway databases

UniPathwayi
UPA00094

UPA00769

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 8 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase 8
Short name:
17-beta-HSD 8
3-ketoacyl-[acyl-carrier-protein] reductase alpha subunitBy similarity
Short name:
KAR alpha subunitBy similarity
3-oxoacyl-[acyl-carrier-protein] reductase (EC:1.1.1.-By similarity)
Testosterone 17-beta-dehydrogenase 8 (EC:1.1.1.239)
Gene namesi
Name:HSD17B8
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000054596‹1 – ›134Estradiol 17-beta-dehydrogenase 8Add BLAST›134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42N6-succinyllysineBy similarity1
Modified residuei55N6-succinyllysineBy similarity1

Interactioni

Subunit structurei

Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4.By similarity

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000040269

Structurei

3D structure databases

ProteinModelPortaliQ9GME3
SMRiQ9GME3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1200 Eukaryota
COG1028 LUCA
HOVERGENiHBG002145
InParanoidiQ9GME3
OrthoDBiEOG091G0N2V

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q9GME3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DWDKVIAVNL KGTFLVTQAA GQALVSSGCS GSIINISSIV GKVGNMGQTN
60 70 80 90 100
YAASKAGVIG LTQTAARELG RHGIRCNSVL PGFIATPMTQ KVPQKVMNKI
110 120 130
TGMIPMGHLG DPEDVADVVA FLASEDSGYI TGAS
Length:134
Mass (Da):13,763
Last modified:March 1, 2001 - v1
Checksum:i1D351CCF6D6181FF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8MEJ8A0A2R8MEJ8_CALJA
Estradiol 17-beta-dehydrogenase 8
HSD17B8
284Annotation score:
F7IJ72F7IJ72_CALJA
Estradiol 17-beta-dehydrogenase 8
HSD17B8
261Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1341

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272012 mRNA Translation: AAG01114.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272012 mRNA Translation: AAG01114.1

3D structure databases

ProteinModelPortaliQ9GME3
SMRiQ9GME3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000040269

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1200 Eukaryota
COG1028 LUCA
HOVERGENiHBG002145
InParanoidiQ9GME3
OrthoDBiEOG091G0N2V

Enzyme and pathway databases

UniPathwayi
UPA00094

UPA00769

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDHB8_CALJA
AccessioniPrimary (citable) accession number: Q9GME3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again