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UniProtKB - Q9GME3 (DHB8_CALJA)
Protein
Estradiol 17-beta-dehydrogenase 8
Gene
HSD17B8
Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Functioni
NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD.
By similarityCatalytic activityi
: estrogen biosynthesis Pathwayi
This protein is involved in the pathway estrogen biosynthesis, which is part of Steroid biosynthesis.By similarityView all proteins of this organism that are known to be involved in the pathway estrogen biosynthesis and in Steroid biosynthesis.
Pathwayi: fatty acid biosynthesis
This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 38 | SubstrateBy similarity | 1 | |
Active sitei | 51 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 51 – 55 | NADBy similarity | 5 | |
Nucleotide bindingi | 84 – 86 | NADBy similarity | 3 |
GO - Molecular functioni
- (3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity Source: UniProtKB
- 17-beta-hydroxysteroid dehydrogenase (NAD+) activity Source: RHEA
- 17-beta-hydroxysteroid dehydrogenase (NADP+) activity Source: RHEA
- estradiol 17-beta-dehydrogenase activity Source: UniProtKB
- NADH binding Source: UniProtKB
- testosterone dehydrogenase (NAD+) activity Source: UniProtKB-EC
GO - Biological processi
- estrogen biosynthetic process Source: UniProtKB
- fatty acid biosynthetic process Source: UniProtKB
- protein heterotetramerization Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis |
Ligand | NAD |
Enzyme and pathway databases
UniPathwayi | UPA00094 UPA00769 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:HSD17B8 |
Organismi | Callithrix jacchus (White-tufted-ear marmoset) |
Taxonomic identifieri | 9483 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Callitrichinae › Callithrix › Callithrix |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion matrix By similarity
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054596 | ‹1 – ›134 | Estradiol 17-beta-dehydrogenase 8Add BLAST | ›134 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 42 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 55 | N6-succinyllysineBy similarity | 1 |
Interactioni
Subunit structurei
Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4.
By similarityProtein-protein interaction databases
STRINGi | 9483.ENSCJAP00000040269 |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Phylogenomic databases
eggNOGi | KOG1200, Eukaryota |
HOGENOMi | CLU_010194_1_3_1 |
InParanoidi | Q9GME3 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q9GME3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
DWDKVIAVNL KGTFLVTQAA GQALVSSGCS GSIINISSIV GKVGNMGQTN
60 70 80 90 100
YAASKAGVIG LTQTAARELG RHGIRCNSVL PGFIATPMTQ KVPQKVMNKI
110 120 130
TGMIPMGHLG DPEDVADVVA FLASEDSGYI TGAS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 | ||
Non-terminal residuei | 134 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF272012 mRNA Translation: AAG01114.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF272012 mRNA Translation: AAG01114.1 |
3D structure databases
AlphaFoldDBi | Q9GME3 |
SMRi | Q9GME3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9483.ENSCJAP00000040269 |
Phylogenomic databases
eggNOGi | KOG1200, Eukaryota |
HOGENOMi | CLU_010194_1_3_1 |
InParanoidi | Q9GME3 |
Enzyme and pathway databases
UniPathwayi | UPA00094 UPA00769 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DHB8_CALJA | |
Accessioni | Q9GME3Primary (citable) accession number: Q9GME3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families