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Entry version 115 (08 May 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Coagulation factor V

Gene

F5

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin.

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by SERPINA5.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi139CalciumBy similarity1
Metal bindingi140CalciumBy similarity1
Metal bindingi1877CopperBy similarity1
Metal bindingi1879CopperBy similarity1
Metal bindingi1919CopperBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulation, Hemostasis
LigandCalcium, Copper, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coagulation factor V
Alternative name(s):
Activated protein C cofactor
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:F5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000298223 – 2258Coagulation factor VAdd BLAST2236
ChainiPRO_000000298323 – 737Coagulation factor V heavy chainBy similarityAdd BLAST715
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000002984738 – 1611Activation peptide (connecting region)By similarityAdd BLAST874
ChainiPRO_00000029851612 – 2258Coagulation factor V light chainBy similarityAdd BLAST647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi167 ↔ 193PROSITE-ProRule annotation
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi248 ↔ 329PROSITE-ProRule annotation
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi467N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi499 ↔ 525PROSITE-ProRule annotation
Glycosylationi553N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi602 ↔ 683PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei639PhosphothreonineBy similarity1
Modified residuei692SulfotyrosineSequence analysis1
Modified residuei696SulfotyrosineSequence analysis1
Modified residuei724SulfotyrosineSequence analysis1
Modified residuei726SulfotyrosineSequence analysis1
Glycosylationi741N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei745SulfotyrosineSequence analysis1
Glycosylationi752N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi760N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi776N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi782N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi899N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi960N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1048N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1057N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1066N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1073N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1089N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1480N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1537N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1560SulfotyrosineSequence analysis1
Modified residuei1576SulfotyrosineSequence analysis1
Modified residuei1581SulfotyrosineSequence analysis1
Modified residuei1584SulfotyrosineSequence analysis1
Modified residuei1588SulfotyrosineSequence analysis1
Glycosylationi1597N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1631SulfotyrosineSequence analysis1
Glycosylationi1737N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1759 ↔ 1785Curated
Glycosylationi1886N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1941 ↔ 2095PROSITE-ProRule annotation
Glycosylationi2044N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2100 ↔ 2255PROSITE-ProRule annotation
Glycosylationi2243N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei737 – 738Cleavage; by thrombinBy similarity2
Sitei1029 – 1030Cleavage; by thrombinBy similarity2
Sitei1611 – 1612Cleavage; by thrombinBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GLP1

PeptideAtlas

More...
PeptideAtlasi
Q9GLP1

PRoteomics IDEntifications database

More...
PRIDEi
Q9GLP1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain, non-covalently bound. The interaction between the two chains is calcium-dependent. Forms heterodimer with SERPINA5 (By similarity).By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000006704

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9GLP1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 329F5/8 type A 1Add BLAST300
Domaini30 – 193Plastocyanin-like 1Add BLAST164
Domaini203 – 329Plastocyanin-like 2Add BLAST127
Domaini348 – 683F5/8 type A 2Add BLAST336
Domaini348 – 525Plastocyanin-like 3Add BLAST178
Domaini535 – 683Plastocyanin-like 4Add BLAST149
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1168 – 117619
Repeati1177 – 118529
Repeati1186 – 119439
Repeati1195 – 120349
Repeati1204 – 121259
Repeati1213 – 122169
Repeati1222 – 123079
Repeati1231 – 123989
Repeati1240 – 124899
Repeati1249 – 1257109
Repeati1258 – 1266119
Repeati1267 – 1275129
Repeati1276 – 1284139
Repeati1285 – 1293149
Repeati1294 – 1302159
Repeati1303 – 1311169
Repeati1312 – 1320179
Repeati1321 – 1329189
Repeati1330 – 1338199
Repeati1339 – 1347209
Repeati1348 – 1356219
Repeati1357 – 1365229
Repeati1366 – 1374239
Repeati1375 – 1383249
Repeati1384 – 1392259
Repeati1393 – 1401269
Repeati1402 – 1410279
Repeati1411 – 1419289
Repeati1420 – 1428299
Repeati1429 – 1437309
Repeati1438 – 1446319
Repeati1447 – 1455329
Repeati1456 – 1464339
Repeati1465 – 1473349
Repeati1474 – 1482359
Repeati1483 – 1491369
Repeati1492 – 1500379
Repeati1501 – 1509389
Repeati1510 – 1518399
Repeati1519 – 1527409
Repeati1531 – 1539419
Domaini1616 – 1941F5/8 type A 3Add BLAST326
Domaini1616 – 1785Plastocyanin-like 5Add BLAST170
Domaini1795 – 1941Plastocyanin-like 6Add BLAST147
Domaini1941 – 2095F5/8 type C 1PROSITE-ProRule annotationAdd BLAST155
Domaini2100 – 2255F5/8 type C 2PROSITE-ProRule annotationAdd BLAST156

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni691 – 1611BAdd BLAST921
Regioni1168 – 153941 X 9 AA approximate tandem repeats of T-L-S-P-D-L-[GS]-[HQ]-TAdd BLAST372

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Domain B contains 41 X 9 AA tandem repeats. Domains C1 and C2 may be involved in membrane binding.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ6Y Eukaryota
ENOG4111F6G LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082542

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9GLP1

KEGG Orthology (KO)

More...
KOi
K03902

Database of Orthologous Groups

More...
OrthoDBi
454773at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00057 FA58C, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 2 hits
2.60.40.420, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009271 Coagulation_factor_V_LSPD
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR008972 Cupredoxin
IPR000421 FA58C
IPR024715 Factor_5/8-like
IPR008979 Galactose-bd-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07732 Cu-oxidase_3, 2 hits
PF00754 F5_F8_type_C, 2 hits
PF06049 LSPR, 36 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000354 Factors_V_VIII, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00231 FA58C, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49503 SSF49503, 6 hits
SSF49785 SSF49785, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS00079 MULTICOPPER_OXIDASE1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GLP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPALPCPWV LVVLGTSWAA WGNLGTEAAR VRQFYVAAQS ISWNYHPEPT
60 70 80 90 100
HPSSSPFATS FKKIVYREYE AYFQKEKPPS RMSGLLGPTL YADVGDIMKV
110 120 130 140 150
HFRNKADKPL SIHPQGIKYS KFAEGASYPD HTFLVEKMDD AVAPGQEYTY
160 170 180 190 200
EWNISEDSGP THNDPPCLTH IYYSYENLIQ DFNSGLIGPL LICKKGTLTE
210 220 230 240 250
DGIQKMFDKQ YVLMFAVFDE SKSWNQSSSL MYTVNGYVNG TMPDITVCAY
260 270 280 290 300
DHISWHLIGM SSGPELFSIH FSGQVLEQNH HKVSAITLVS ATSTTANMTV
310 320 330 340 350
SPEGKWPISS LIPKHFQAGM QAYIDIKNCA KKTRKPKKLT RDQRRHIKRW
360 370 380 390 400
EYFIAAEEVI WDYAPIIPAN MDKKYRSLHL DNFSNQIGKH YKKVVYKQYQ
410 420 430 440 450
DESFTKRLEN PNNKEDGILG PVIRAQVRDT LKIVFKNMAS RSYSIYPHGV
460 470 480 490 500
TFSPYEDDVN SSSTSDNNTM IRAVQPGETY TYKWNILESD EPTENDAQCL
510 520 530 540 550
TRPYYSNVDI TRDIASGLIG LLLICKSRSL DKRGIQRTAD IEQKAVFAVF
560 570 580 590 600
DENKSWYIED NIYKFCENPE KVKRDDPKFY ESNIMSTING YVPESIPTLG
610 620 630 640 650
FCFDDTVQWH FCSVRTHDNI LTIHFTGHSF IYGKRHEDTL TLFPMRGESV
660 670 680 690 700
TVTMDNVGTW MLTTMNSNPR NKKLQLKFRD VKCIRDDDED SYEIIYEPSS
710 720 730 740 750
STTLTTRKMH DSSENKEEEN DDEYDYQDLL ASVLGIRSFR NSSLYQEDDE
760 770 780 790 800
FNLTALALEN NSEFIPPSTD RAVDSNSSSP GNISRAPANT FTEPRKILPH
810 820 830 840 850
PEATKAGSPR RHTGLVKNLV LNRRRTQHSD PYSEDPIENP LQSVITGISL
860 870 880 890 900
LPFGTEGFRN REHPKHKRFK AGRDQAAKHR FSQMEFPAHK TGRHISQDNS
910 920 930 940 950
SSSSMGPLED LSSDLLLLER KDPSTINGKW HLVSEKGSYE IVQDADEDMA
960 970 980 990 1000
VNKLPNNPQN ASRSWGENIP FTNKHGKQRG HPIFVTRHKL LQERQDEGNS
1010 1020 1030 1040 1050
ILKKGRFFIR TRRKKKERKP VHHVPLSPRS FNPLRGEANT PFSDRRQNHS
1060 1070 1080 1090 1100
LLLHESNETF PPTDLNQTFP SMNLSLIASH PDHNQNLPND THQTSSPLDL
1110 1120 1130 1140 1150
YQTVTPDEPY QTAPIQDLDP THSTAVPSHQ SSLPEPIQMH DYDLRNKASP
1160 1170 1180 1190 1200
TDVSEMFFSL KLKAGHRTTS PDLNQTSLSP ELSQTTLSPD PGHVTLSPDL
1210 1220 1230 1240 1250
SQTTLSPDLS HTTLSPDLGH TTLSPDLSHT TLSPDLSQTT LSPDLSHTTL
1260 1270 1280 1290 1300
SPDLGHTTLS PDLSHTTLSP DLGHATLSPD LSHTTLSPDL GHTTLSPDLG
1310 1320 1330 1340 1350
HTTLSPDFSQ TTLSPDLGHT TLSSDVSHTT LSPDLSHTTL SPDLSHTTLS
1360 1370 1380 1390 1400
PDLGHTTLSP DLSQTTLSPD LGHMTLSPDL SHTTLSPDLG HTTLSPDLSH
1410 1420 1430 1440 1450
TTLSPDLGHM TLSPDLGQTT LSLDFGQTTL SPDLSHMTLS SELSHETLSP
1460 1470 1480 1490 1500
DLSQVTLSPD LSEIPFSPDL WQTTLSSDLN ETTLSPDLRQ TSPHPDPDKT
1510 1520 1530 1540 1550
SYISESSQSV TLPEFGQTSP FPDLGQRPSP PSHSTLNNTF IPREFNPMVV
1560 1570 1580 1590 1600
VGLSRDDGDY VEIIPRQQEE NSEEDYVKID YVEYDDPYQT DVRTDINSSR
1610 1620 1630 1640 1650
NPDNIAAWYL RSNNGNRRNY YIAAEELSWD YSKFTQREDI DDVPEHTIYK
1660 1670 1680 1690 1700
KVVFRKYLDS TFTKLDPRGE YEEHLGILGP IIRAEVDDVI QVRFKNLASR
1710 1720 1730 1740 1750
PYSLHAHGLS YEKSSEGKTY EDDSPEWFKE DNAVQPNSSY TYVWHATERS
1760 1770 1780 1790 1800
GPESPGSACR AWAYYSAVNP EKDIHSGLIG PLLICRKGTL HKENNMPVDM
1810 1820 1830 1840 1850
REFVLLFMVF DEKKSWYYEK KFTRSWRLTS SEVKNSHKFH AINGMIYNLP
1860 1870 1880 1890 1900
GLRMYEQEWV RLHLLNLGGS RDIHVVHFHG QTLLENGTQQ HQLGVWPLLP
1910 1920 1930 1940 1950
GSFKTLEMKT SKAGWWLLDT EVGENQRAGM QTPFLIIDRE CKMPMGLSTG
1960 1970 1980 1990 2000
LIADSQIKAS EFWGHWQPKL ARLNNGGSYN AWITDKFSGE SNSKPWIQVD
2010 2020 2030 2040 2050
MQREVVFTGI QTQGAKYYLK SYYTTEFNVA YSSDQRNWRI FKGNSTKNVM
2060 2070 2080 2090 2100
YFNGNSDAST ITENQFDPPV VARYIRISPT ESYNKPALRL ELQGCEVNGC
2110 2120 2130 2140 2150
STPLGMESGN IKNEQITASS FKKSWWGDYW EPFRARLNAQ GRVNAWQAKA
2160 2170 2180 2190 2200
NNNNQWLQID LLKIKKITAI TTQGCKSLSS EMYVKRYTIQ YSDRGVEWKS
2210 2220 2230 2240 2250
YREKSSMVDK IFEGNNNIKG HVKNFFNPPI ISRFIRIIPK MWNQSIALRL

ELFGCDIY
Length:2,258
Mass (Da):256,080
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9159B9E0076A2ACC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF191308 mRNA Translation: AAG28381.1

NCBI Reference Sequences

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RefSeqi
NP_999285.1, NM_214120.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
397217

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ssc:397217

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191308 mRNA Translation: AAG28381.1
RefSeqiNP_999285.1, NM_214120.1

3D structure databases

SMRiQ9GLP1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006704

Proteomic databases

PaxDbiQ9GLP1
PeptideAtlasiQ9GLP1
PRIDEiQ9GLP1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397217
KEGGissc:397217

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2153

Phylogenomic databases

eggNOGiENOG410IJ6Y Eukaryota
ENOG4111F6G LUCA
HOGENOMiHOG000082542
InParanoidiQ9GLP1
KOiK03902
OrthoDBi454773at2759

Family and domain databases

CDDicd00057 FA58C, 2 hits
Gene3Di2.60.120.260, 2 hits
2.60.40.420, 5 hits
InterProiView protein in InterPro
IPR009271 Coagulation_factor_V_LSPD
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR008972 Cupredoxin
IPR000421 FA58C
IPR024715 Factor_5/8-like
IPR008979 Galactose-bd-like_sf
PfamiView protein in Pfam
PF07732 Cu-oxidase_3, 2 hits
PF00754 F5_F8_type_C, 2 hits
PF06049 LSPR, 36 hits
PIRSFiPIRSF000354 Factors_V_VIII, 1 hit
SMARTiView protein in SMART
SM00231 FA58C, 2 hits
SUPFAMiSSF49503 SSF49503, 6 hits
SSF49785 SSF49785, 2 hits
PROSITEiView protein in PROSITE
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS00079 MULTICOPPER_OXIDASE1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA5_PIG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GLP1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: May 8, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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