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Entry version 87 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Secretogranin-1

Gene

CHGB

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.

Caution

PubMed:11168356 reported the oxidation of Met-651 to sulfoxide. This is most probably an artifact of isolation.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Secretogranin-1
Alternative name(s):
Chromogranin-B
Short name:
CgB
Secretogranin I
Short name:
SgI
Cleaved into the following 5 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHGB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced
  • UP000008227 Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000544221 – 668Secretogranin-1Add BLAST648
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_0000432732566 – 576PE-11By similarityAdd BLAST11
PeptideiPRO_0000411989606 – 668CCB peptideBy similarityAdd BLAST63
PeptideiPRO_0000005443606 – 622Peptide SR-17Add BLAST17
PeptideiPRO_0000005444623 – 656Peptide HQ-34Add BLAST34
PeptideiPRO_0000005445657 – 667Peptide KR-11Add BLAST11

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 57By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei79PhosphothreonineCurated1
Modified residuei92PhosphothreonineSequence analysis1
Modified residuei93PhosphoserineBy similarity1
Modified residuei99PhosphoserineSequence analysis1
Modified residuei126PhosphoserineBy similarity1
Modified residuei179PhosphoserineBy similarity1
Modified residuei217PhosphoserineBy similarity1
Modified residuei306PhosphoserineBy similarity1
Modified residuei330PhosphoserineBy similarity1
Modified residuei375PhosphoserineBy similarity1
Modified residuei396PhosphoserineSequence analysis1
Modified residuei399PhosphoserineSequence analysisBy similarity1
Modified residuei524PhosphoserineSequence analysis1
Modified residuei525PhosphoserineSequence analysis1
Modified residuei557SulfotyrosineBy similarity1
Modified residuei606PhosphoserineBy similarity1
Modified residuei613SulfotyrosineBy similarity1
Modified residuei615Phosphoserine1 Publication1
Modified residuei620Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Peptide SR-17 exists in both monophosphorylated and diphosphorylated forms.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein, Sulfation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GLG4

PRoteomics IDEntifications database

More...
PRIDEi
Q9GLG4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9GLG4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000007507

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi162 – 167Poly-Glu6
Compositional biasi342 – 345Poly-Ser4
Compositional biasi639 – 646Poly-Glu8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRBF, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9GLG4

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001819, Chromogranin_AB
IPR018054, Chromogranin_CS
IPR001990, Granin

The PANTHER Classification System

More...
PANTHERi
PTHR10583, PTHR10583, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01271, Granin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00659, CHROMOGRANIN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00422, GRANINS_1, 1 hit
PS00423, GRANINS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GLG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPAVLLGFL GATVVAAVSS MPVDNRNHNE EMVAHCIIEV LSNALSKSNA
60 70 80 90 100
PPITPECRQV LKKGGKEVKD EEKGANENTR FEVRLLRDPA DTSETQRPSG
110 120 130 140 150
GREGAEAPSE DTQGPPGADV EGGGHSREGA GKPRGGPYSS DNPVAKEGKT
160 170 180 190 200
RHSEKSEGQD REEEEGEKYQ KRERGEEGSE ERHLQEPGET QTAFLNQGNR
210 220 230 240 250
ATAKKKEEFE SRYDAHSAGG PAKTHSRERS SQESGEETGS QDAAPGEPES
260 270 280 290 300
PPEGQEAPEE SQEDASLEVD KRRWRPRHHH GRSRPDRAPQ EGSPPPEERG
310 320 330 340 350
HPREESEESV LGLASPGGQR TRHPTHYPAS EEEAEHGEEV RSSSSVQAPG
360 370 380 390 400
DLVGARYGGR GGAEHRAARR PGEESPEQDR RVGASSELRN KGPGHSEESE
410 420 430 440 450
EERGDEGQRH HRAWAGGPRA DAPPDPAEEE QFWGEAHRPV PESQVDEARR
460 470 480 490 500
HPQAKLRNYL NRGEENGEEG APGRWQQPED LQGPGEHAAE ARLPGKPYAA
510 520 530 540 550
HRIPEKKRLG ELLNPYYVPP QWESSHFERK DNVGDNFLEG EDANGVTLNE
560 570 580 590 600
KTFFPEYSYD WWEKKPFEED VNWGYEERNL APKLDLKRQY DRVAELDQLL
610 620 630 640 650
HYRKKSAEFP DFYDSGEHLS PRHAAESEKE RAGQGVLTEE EEKELENLAA
660
MDLELQKIAE KFSGNRRG
Length:668
Mass (Da):74,392
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC8694D09388D5E8
GO

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 2034.04 Da. Determined by ESI. With 1 phosphate group.1 Publication
Molecular mass is 2115.42 Da. Determined by ESI. With 2 phosphate groups.1 Publication
Molecular mass is 3815.56 Da. Determined by ESI. 1 Publication
Molecular mass is 1305.34 Da. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF284349 mRNA Translation: AAG13399.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00040071128; ENSSSCP00040030327; ENSSSCG00040052597
ENSSSCT00045063331; ENSSSCP00045044656; ENSSSCG00045036764
ENSSSCT00055056131; ENSSSCP00055044839; ENSSSCG00055028282

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284349 mRNA Translation: AAG13399.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007507

PTM databases

iPTMnetiQ9GLG4

Proteomic databases

PaxDbiQ9GLG4
PRIDEiQ9GLG4

Genome annotation databases

EnsembliENSSSCT00040071128; ENSSSCP00040030327; ENSSSCG00040052597
ENSSSCT00045063331; ENSSSCP00045044656; ENSSSCG00045036764
ENSSSCT00055056131; ENSSSCP00055044839; ENSSSCG00055028282

Phylogenomic databases

eggNOGiENOG502QRBF, Eukaryota
InParanoidiQ9GLG4

Family and domain databases

InterProiView protein in InterPro
IPR001819, Chromogranin_AB
IPR018054, Chromogranin_CS
IPR001990, Granin
PANTHERiPTHR10583, PTHR10583, 1 hit
PfamiView protein in Pfam
PF01271, Granin, 1 hit
PRINTSiPR00659, CHROMOGRANIN
PROSITEiView protein in PROSITE
PS00422, GRANINS_1, 1 hit
PS00423, GRANINS_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCG1_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GLG4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: March 1, 2001
Last modified: December 2, 2020
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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