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Protein

Orexin

Gene

HCRT

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-CFA-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-CFA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin
Alternative name(s):
Hypocretin
Short name:
Hcrt
Cleaved into the following 2 chains:
Alternative name(s):
Hypocretin-1
Short name:
Hcrt1
Alternative name(s):
Hypocretin-2
Short name:
Hcrt2
Gene namesi
Name:HCRT
Synonyms:OX, PPOX
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Organism-specific databases

VGNCiVGNC:41622 HCRT

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32By similarityAdd BLAST32
PeptideiPRO_000002025833 – 65Orexin-AAdd BLAST33
PeptideiPRO_000002025969 – 96Orexin-BAdd BLAST28
PropeptideiPRO_000002026097 – 130Add BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi38 ↔ 44By similarity
Disulfide bondi39 ↔ 46By similarity
Modified residuei65Leucine amideBy similarity1
Modified residuei96Methionine amideBy similarity1

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ9GLF6

Expressioni

Gene expression databases

BgeeiENSCAFG00000015615 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000022949

Structurei

3D structure databases

ProteinModelPortaliQ9GLF6
SMRiQ9GLF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the orexin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4FI Eukaryota
ENOG410Y5WS LUCA
GeneTreeiENSGT00390000014272
HOGENOMiHOG000230990
HOVERGENiHBG000256
InParanoidiQ9GLF6
KOiK05246
OMAiSECCRQP
OrthoDBiEOG091G0K5S
TreeFamiTF330756

Family and domain databases

InterProiView protein in InterPro
IPR001704 Orexin
PANTHERiPTHR15173 PTHR15173, 1 hit
PfamiView protein in Pfam
PF02072 Orexin, 1 hit
PIRSFiPIRSF037824 Orexin, 1 hit
PRINTSiPR01091 OREXINPP

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GLF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPPSTKVPW AAVTLLLLLL LPPALLSPGA AAQPLPDCCR QKTCSCRLYE
60 70 80 90 100
LLHGAGNHAA GILTLGKRRP GPPGLQGRLQ RLLQASGNHA AGILTMGRRA
110 120 130
GAEPAPRPCP GRRCPVVAVP SAAPGGRSGV
Length:130
Mass (Da):13,328
Last modified:March 1, 2001 - v1
Checksum:i2BF59D4C1E422DF3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti30A → T1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285110 Genomic DNA Translation: AAG13965.1
RefSeqiNP_001029166.1, NM_001033994.1
XP_005624415.1, XM_005624358.1
UniGeneiCfa.24652

Genome annotation databases

EnsembliENSCAFT00000024739; ENSCAFP00000022949; ENSCAFG00000015615
GeneIDi607641
KEGGicfa:607641

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

Qui dort dine - Issue 15 of October 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285110 Genomic DNA Translation: AAG13965.1
RefSeqiNP_001029166.1, NM_001033994.1
XP_005624415.1, XM_005624358.1
UniGeneiCfa.24652

3D structure databases

ProteinModelPortaliQ9GLF6
SMRiQ9GLF6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000022949

Proteomic databases

PaxDbiQ9GLF6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000024739; ENSCAFP00000022949; ENSCAFG00000015615
GeneIDi607641
KEGGicfa:607641

Organism-specific databases

CTDi3060
VGNCiVGNC:41622 HCRT

Phylogenomic databases

eggNOGiENOG410J4FI Eukaryota
ENOG410Y5WS LUCA
GeneTreeiENSGT00390000014272
HOGENOMiHOG000230990
HOVERGENiHBG000256
InParanoidiQ9GLF6
KOiK05246
OMAiSECCRQP
OrthoDBiEOG091G0K5S
TreeFamiTF330756

Enzyme and pathway databases

ReactomeiR-CFA-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-CFA-416476 G alpha (q) signalling events

Gene expression databases

BgeeiENSCAFG00000015615 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Family and domain databases

InterProiView protein in InterPro
IPR001704 Orexin
PANTHERiPTHR15173 PTHR15173, 1 hit
PfamiView protein in Pfam
PF02072 Orexin, 1 hit
PIRSFiPIRSF037824 Orexin, 1 hit
PRINTSiPR01091 OREXINPP
ProtoNetiSearch...

Entry informationi

Entry nameiOREX_CANLF
AccessioniPrimary (citable) accession number: Q9GLF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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