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UniProtKB - Q9GLE3 (CATK_PIG)
Protein
Cathepsin K
Gene
CTSK
Organism
Sus scrofa (Pig)
Status
Functioni
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity).
Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
By similarity1 PublicationCatalytic activityi
- Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg. EC:3.4.22.38
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 140 | By similarity | 1 | |
Active sitei | 277 | By similarity | 1 | |
Active sitei | 297 | By similarity | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: GO_Central
GO - Biological processi
- immune response Source: GO_Central
- proteolysis involved in cellular protein catabolic process Source: GO_Central
- thyroid hormone generation Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Protein family/group databases
MEROPSi | I29.007 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CTSK |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Lysosome
- Lysosome 1 Publication
Plasma membrane
- Apical cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Extracellular side 1 Publication
Note: Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.1 Publication
Extracellular region or secreted
- extracellular space Source: UniProtKB
Lysosome
- lysosome Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Lysosome, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
PropeptideiPRO_0000026303 | 17 – 115 | Activation peptideAdd BLAST | 99 | |
ChainiPRO_0000026304 | 116 – 330 | Cathepsin KAdd BLAST | 215 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 104 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 137 ↔ 178 | By similarity | ||
Disulfide bondi | 171 ↔ 211 | By similarity | ||
Disulfide bondi | 270 ↔ 319 | By similarity |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenProteomic databases
PaxDbi | Q9GLE3 |
PRIDEi | Q9GLE3 |
Expressioni
Tissue specificityi
Expressed in the thyroid epithelial cells.1 Publication
Gene expression databases
Bgeei | ENSSSCG00000006647, Expressed in adipose tissue and 48 other tissues |
Genevisiblei | Q9GLE3, SS |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase C1 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1543, Eukaryota |
HOGENOMi | CLU_012184_1_2_1 |
InParanoidi | Q9GLE3 |
OrthoDBi | 1275401at2759 |
TreeFami | TF313739 |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR015644, Peptidase_C1A_cathepsin-K IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
PANTHERi | PTHR12411:SF55, PTHR12411:SF55, 1 hit |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9GLE3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWGLKVVLLL PVMSSALYPE EILDTQWELW KKTYRKQYNS KVDEISRRLI
60 70 80 90 100
WEKNLKHISI HNLEASLGVH TYELAMNHLG DMTSEEVVQK MTGLKVPPSH
110 120 130 140 150
SRSNDTLYIP DWEGRTPDSI DYRKKGYVTP VKNQGQCGSC WAFSSVGALE
160 170 180 190 200
GQLKKKTGKL LNLSPQNLVD CVSENDGCGG GYMTNAFQYV QKNRGIDSED
210 220 230 240 250
AYPYVGQDEN CMYNPTGKAA KCRGYREIPE GNEKALKRAV ARVGPVSVAI
260 270 280 290 300
DASLTSFQFY SKGVYYDENC NSDNLNHAVL AVGYGIQKGK KHWIIKNSWG
310 320 330
ENWGNKGYIL MARNKNNACG IANLASFPKM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF292030 mRNA Translation: AAG12340.1 |
RefSeqi | NP_999467.1, NM_214302.1 XP_005663523.1, XM_005663466.2 |
Genome annotation databases
Ensembli | ENSSSCT00070000544; ENSSSCP00070000469; ENSSSCG00070000306 |
GeneIDi | 397569 |
KEGGi | ssc:397569 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF292030 mRNA Translation: AAG12340.1 |
RefSeqi | NP_999467.1, NM_214302.1 XP_005663523.1, XM_005663466.2 |
3D structure databases
AlphaFoldDBi | Q9GLE3 |
SMRi | Q9GLE3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000007088 |
Protein family/group databases
MEROPSi | I29.007 |
Proteomic databases
PaxDbi | Q9GLE3 |
PRIDEi | Q9GLE3 |
Genome annotation databases
Ensembli | ENSSSCT00070000544; ENSSSCP00070000469; ENSSSCG00070000306 |
GeneIDi | 397569 |
KEGGi | ssc:397569 |
Organism-specific databases
CTDi | 1513 |
Phylogenomic databases
eggNOGi | KOG1543, Eukaryota |
HOGENOMi | CLU_012184_1_2_1 |
InParanoidi | Q9GLE3 |
OrthoDBi | 1275401at2759 |
TreeFami | TF313739 |
Gene expression databases
Bgeei | ENSSSCG00000006647, Expressed in adipose tissue and 48 other tissues |
Genevisiblei | Q9GLE3, SS |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR015644, Peptidase_C1A_cathepsin-K IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
PANTHERi | PTHR12411:SF55, PTHR12411:SF55, 1 hit |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CATK_PIG | |
Accessioni | Q9GLE3Primary (citable) accession number: Q9GLE3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 14, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families