UniProtKB - Q9GL44 (Q9GL44_MACMU)
Protein
Colony-stimulating factor
Gene
CSF2
Organism
Macaca mulatta (Rhesus macaque)
Status
Functioni
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.ARBA annotation
GO - Molecular functioni
- cytokine activity Source: GO_Central
- granulocyte macrophage colony-stimulating factor receptor binding Source: InterPro
- growth factor activity Source: InterPro
GO - Biological processi
- cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
- embryonic placenta development Source: Ensembl
- immune response Source: InterPro
- macrophage differentiation Source: Ensembl
- monocyte differentiation Source: Ensembl
- myeloid cell differentiation Source: GO_Central
- myeloid dendritic cell differentiation Source: Ensembl
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
- negative regulation of transcription, DNA-templated Source: Ensembl
- neutrophil differentiation Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of interleukin-23 production Source: Ensembl
- positive regulation of macrophage derived foam cell differentiation Source: Ensembl
- positive regulation of podosome assembly Source: Ensembl
- positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: Colony-stimulating factorARBA annotationAlternative name(s): Granulocyte-macrophage colony-stimulating factorARBA annotation |
Gene namesi | |
Organismi | Macaca mulatta (Rhesus macaque)Imported |
Taxonomic identifieri | 9544 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:71516, CSF2 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- intracellular membrane-bounded organelle Source: Ensembl
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5014108079 | 18 – 144 | Colony-stimulating factorSequence analysisAdd BLAST | 127 |
Expressioni
Gene expression databases
Bgeei | ENSMMUG00000016915, Expressed in lung and 3 other tissues |
Interactioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- granulocyte macrophage colony-stimulating factor receptor binding Source: InterPro
- growth factor activity Source: InterPro
Protein-protein interaction databases
STRINGi | 9544.ENSMMUP00000022240 |
Family & Domainsi
Sequence similaritiesi
Belongs to the GM-CSF family.ARBA annotation
Keywords - Domaini
SignalSequence analysisARBA annotationPhylogenomic databases
eggNOGi | ENOG502TDUI, Eukaryota |
GeneTreei | ENSGT00390000013425 |
HOGENOMi | CLU_152286_0_0_1 |
OMAi | VTRPWKH |
OrthoDBi | 1412355at2759 |
TreeFami | TF338611 |
Family and domain databases
CDDi | cd00040, CSF2, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000773, GM_colony-stim-fac |
PANTHERi | PTHR10059, PTHR10059, 1 hit |
Pfami | View protein in Pfam PF01109, GM_CSF, 1 hit |
PRINTSi | PR00693, GMCSFACTOR |
SMARTi | View protein in SMART SM00040, CSF2, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00702, GM_CSF, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9GL44-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWLQGLLLLG TVACSISAPA RSPSPGTQPW EHVNAIQEAR RLLNLSRDTA
60 70 80 90 100
AEMNKTVEVV SEMFDLQEPS CLQTRLELYK QGLQGSLTKL KGPLTMMASH
110 120 130 140
YKQHCPPTPE TSCATQIITF QSFKENLKDF LLVIPFDCWE PVQE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY007376 mRNA Translation: AAG16626.1 |
RefSeqi | NP_001028121.1, NM_001032949.1 |
Genome annotation databases
Ensembli | ENSMMUT00000023763; ENSMMUP00000022240; ENSMMUG00000016915 |
GeneIDi | 574371 |
KEGGi | mcc:574371 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY007376 mRNA Translation: AAG16626.1 |
RefSeqi | NP_001028121.1, NM_001032949.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9544.ENSMMUP00000022240 |
Genome annotation databases
Ensembli | ENSMMUT00000023763; ENSMMUP00000022240; ENSMMUG00000016915 |
GeneIDi | 574371 |
KEGGi | mcc:574371 |
Organism-specific databases
CTDi | 1437 |
VGNCi | VGNC:71516, CSF2 |
Phylogenomic databases
eggNOGi | ENOG502TDUI, Eukaryota |
GeneTreei | ENSGT00390000013425 |
HOGENOMi | CLU_152286_0_0_1 |
OMAi | VTRPWKH |
OrthoDBi | 1412355at2759 |
TreeFami | TF338611 |
Gene expression databases
Bgeei | ENSMMUG00000016915, Expressed in lung and 3 other tissues |
Family and domain databases
CDDi | cd00040, CSF2, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000773, GM_colony-stim-fac |
PANTHERi | PTHR10059, PTHR10059, 1 hit |
Pfami | View protein in Pfam PF01109, GM_CSF, 1 hit |
PRINTSi | PR00693, GMCSFACTOR |
SMARTi | View protein in SMART SM00040, CSF2, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00702, GM_CSF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9GL44_MACMU | |
Accessioni | Q9GL44Primary (citable) accession number: Q9GL44 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |