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UniProtKB - Q9GKS6 (AT10D_MACFA)
Protein
Phospholipid-transporting ATPase VD
Gene
ATP10D
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Functioni
Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane.
By similarityCatalytic activityi
- a β-D-glucosyl-(1↔1ʼ)-N-acylsphing-4-enine(out) + ATP + H2O = a β-D-glucosyl-(1↔1ʼ)-N-acylsphing-4-enine(in) + ADP + H+ + phosphateBy similarityThis reaction proceeds in the forwardBy similarity direction.
- ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).By similarity EC:7.6.2.1
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 319 | MagnesiumBy similarity | 1 | |
Metal bindingi | 323 | MagnesiumBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 259 – 266 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATPase-coupled intramembrane lipid transporter activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- magnesium ion binding Source: InterPro
GO - Biological processi
- phospholipid translocation Source: InterPro
Keywordsi
Molecular function | Translocase |
Biological process | Lipid transport, Transport |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Phospholipid-transporting ATPase VD (EC:7.6.2.1By similarity)Alternative name(s): ATPase class V type 10D P4-ATPase flippase complex alpha subunit ATP10D |
Gene namesi | Name:ATP10D ORF Names:QnpA-21212 |
Organismi | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
Taxonomic identifieri | 9541 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
Note: Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | ‹1 – 375 | CytoplasmicSequence analysisAdd BLAST | ›375 | |
Transmembranei | 376 – 396 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 397 – 407 | Exoplasmic loopSequence analysisAdd BLAST | 11 | |
Transmembranei | 408 – 428 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 429 – 458 | CytoplasmicSequence analysisAdd BLAST | 30 | |
Transmembranei | 459 – 480 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 481 – 487 | Exoplasmic loopSequence analysis | 7 | |
Transmembranei | 488 – 510 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 511 – 516 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 517 – 537 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 538 – 555 | Exoplasmic loopSequence analysisAdd BLAST | 18 | |
Transmembranei | 556 – 580 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 581 – 653 | CytoplasmicSequence analysisAdd BLAST | 73 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046383 | ‹1 – 653 | Phospholipid-transporting ATPase VDAdd BLAST | ›653 |
Post-translational modificationi
Autophosphorylated at the conserved aspartate of the P-type ATPase signature sequence.By similarity
Interactioni
Subunit structurei
Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP10A and an accessory beta subunit TMEM30A.
By similarityProtein-protein interaction databases
STRINGi | 9541.XP_005554880.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0206, Eukaryota |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR030360, ATP10D IPR023299, ATPase_P-typ_cyto_dom_N IPR023298, ATPase_P-typ_TM_dom_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006539, P-type_ATPase_IV IPR001757, P_typ_ATPase IPR032630, P_typ_ATPase_c |
PANTHERi | PTHR24092:SF84, PTHR24092:SF84, 1 hit |
Pfami | View protein in Pfam PF16212, PhoLip_ATPase_C, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01652, ATPase-Plipid, 1 hit TIGR01494, ATPase_P-type, 2 hits |
i Sequence
Sequence statusi: Fragment.
Q9GKS6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MACNLCYEAE SPDEAALVYA ARAYQCTLQS RTPEQVMVDF AASGPLTFQL
60 70 80 90 100
LHILPFDSVR KRMSVVVRHP LSNQVVVYTK GADSVIMELL SVASPDGAGP
110 120 130 140 150
EKQQMIIREK TQRHLDDYAK QGLRTLCIAK KVMSDTEYAE WLRNHFLAET
160 170 180 190 200
SIDNREELLL ESAMRLENKL TLLGATGIED RLQEGVPESI EALHKAGIKI
210 220 230 240 250
WMLTGDKQET AVNIAYACML MSTILKELQK KTQALPEQVS LSVDLHQPPV
260 270 280 290 300
PQDSGLRAGL IITGKTLEFA LQESLQKQFL ELTSWCQTVV CCRATPLQKS
310 320 330 340 350
EVVKLVRSHL QVMTLAIGDG ANDVSMIQVA DIGIGVSGQE GMQAVMASDF
360 370 380 390 400
AVSQFKHLSK LLLVHGHWCY TRLSNMILYF FYKNVAYVNL LFWYQFFCGF
410 420 430 440 450
SGTSMTDYWV LIFFNLLFTS APPVIYGVLE KDVSAETLMQ LPELYKSGQK
460 470 480 490 500
SEAYLPHTFW ITLLDAFYQS LVCFFVPYFT YQGSDIDIFA FGNPLNTAAL
510 520 530 540 550
FIILLHLIIE SKSLTWIHML VITGSILSYF LFAIVFGAMC VTCNPPSNPY
560 570 580 590 600
WIMQEHVLDP VFYLVCILTT CIALLPRFVY RGAGKMNQVT SNYANQSADK
610 620 630 640 650
SGRRPKPGPS TVFAMKSATS CAIEQGNLSL CETALDQGYS ETKAFEMARP
CKD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB052153 mRNA Translation: BAB19008.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB052153 mRNA Translation: BAB19008.1 |
3D structure databases
AlphaFoldDBi | Q9GKS6 |
SMRi | Q9GKS6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9541.XP_005554880.1 |
Phylogenomic databases
eggNOGi | KOG0206, Eukaryota |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR030360, ATP10D IPR023299, ATPase_P-typ_cyto_dom_N IPR023298, ATPase_P-typ_TM_dom_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006539, P-type_ATPase_IV IPR001757, P_typ_ATPase IPR032630, P_typ_ATPase_c |
PANTHERi | PTHR24092:SF84, PTHR24092:SF84, 1 hit |
Pfami | View protein in Pfam PF16212, PhoLip_ATPase_C, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01652, ATPase-Plipid, 1 hit TIGR01494, ATPase_P-type, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | AT10D_MACFA | |
Accessioni | Q9GKS6Primary (citable) accession number: Q9GKS6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families