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Protein

Dynein regulatory complex protein 9

Gene

IQCG

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca2+ levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein regulatory complex protein 9By similarity
Alternative name(s):
IQ domain-containing protein G
Gene namesi
Name:IQCG
Synonyms:DRC9By similarity
ORF Names:QnpA-20160
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002825621 – 443Dynein regulatory complex protein 9Add BLAST443

Proteomic databases

PRIDEiQ9GKR7

Interactioni

Subunit structurei

Component of the nexin-dynein regulatory complex (N-DRC). Interacts (via IQ domain) with CALM when calcium levels are low. Does not interact with CALM in the presence of Ca2+. Interacts with the HSP70 proteins HSPA1L and HSPA8. May form a complex with CAMK4 and HSP70.By similarity

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ9GKR7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini393 – 422IQPROSITE-ProRule annotationAdd BLAST30

Domaini

The IQ domain mediates interaction with calmodulin when cellular Ca2+ levels are low.By similarity

Sequence similaritiesi

Belongs to the DRC9 family.Curated

Phylogenomic databases

HOVERGENiHBG083921

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

Sequencei

Sequence statusi: Complete.

Q9GKR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEDSQEDSN LPPKVWHSEM TVSVTGKPPS TVEEDGLPKE TDVETIPEIL
60 70 80 90 100
ETREPLSLPD VLRISAVLED TTDQLSILNY IMPIQYEGRQ SVCVKSREMN
110 120 130 140 150
LEGKNLDKLP VASTVTKTPS PLITKERPSL PEIRQGGQFA VEFCKTQDLL
160 170 180 190 200
FKKPARQTIM TTETLKKIQI DRQFFSDVIA DTIEELQDSG TYNSLLQALS
210 220 230 240 250
KERENKMHFY DVIAREEKGR KQIISLQKQL INVKKEWQFE VQSQNEYIAN
260 270 280 290 300
LKDQLQEMKA KSNLENRYMK TNTELQIAQT QRKCNRTEEV LLEEIEKLRM
310 320 330 340 350
KTEEEARIHM DIEMFLRKQQ QKLEERLEFW MEKYDKDTEM KQNELNALKA
360 370 380 390 400
TKASDLAHLQ DLAKTIRECE QVIIEDRIEK EKSKNKIEQD LLELKSVIKL
410 420 430 440
QAWWRGTMIR REIGGFKMPK DKVDSKDSKG KGKGKDKRRG KKK
Length:443
Mass (Da):51,708
Last modified:March 1, 2001 - v1
Checksum:iBC6AA6AF38661395
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052178 mRNA Translation: BAB18984.1
RefSeqiNP_001271774.1, NM_001284845.1
UniGeneiMfa.77

Genome annotation databases

GeneIDi102121144
KEGGimcf:102121144

Similar proteinsi

Entry informationi

Entry nameiDRC9_MACFA
AccessioniPrimary (citable) accession number: Q9GKR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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