UniProtKB - Q9GKL7 (ANDR_PIG)
Androgen receptor
AR
Functioni
Miscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 682 | 17beta-hydroxy-5alpha-androstan-3-oneBy similarity | 1 | |
Binding sitei | 729 | 17beta-hydroxy-5alpha-androstan-3-oneBy similarity | 1 | |
Binding sitei | 854 | 17beta-hydroxy-5alpha-androstan-3-oneBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 535 – 608 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 74 | |
Zinc fingeri | 536 – 556 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 572 – 596 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- androgen binding Source: UniProtKB
- beta-catenin binding Source: UniProtKB
- DNA-binding transcription factor activity Source: UniProtKB
- nuclear receptor activity Source: UniProtKB
- steroid binding Source: UniProtKB-KW
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- androgen receptor signaling pathway Source: UniProtKB
- intracellular receptor signaling pathway Source: BHF-UCL
- negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
- negative regulation of integrin biosynthetic process Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of phosphorylation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of protein localization to plasma membrane Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Lipid-binding, Metal-binding, Steroid-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Androgen receptorAlternative name(s): Dihydrotestosterone receptor Nuclear receptor subfamily 3 group C member 4 |
Gene namesi | Name:AR Synonyms:NR3C4 |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Note: Detected at the promoter of target genes. Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1.By similarity
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053710 | 1 – 896 | Androgen receptorAdd BLAST | 896 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 65 | Phosphoserine; by CDK9By similarity | 1 | |
Modified residuei | 81 | PhosphoserineBy similarity | 1 | |
Modified residuei | 215 | Phosphotyrosine; by CSKBy similarity | 1 | |
Modified residuei | 248 | PhosphoserineBy similarity | 1 | |
Modified residuei | 259 | Phosphotyrosine; by CSK and TNK2By similarity | 1 | |
Modified residuei | 299 | Phosphotyrosine; by CSKBy similarity | 1 | |
Modified residuei | 338 | Phosphotyrosine; by CSKBy similarity | 1 | |
Modified residuei | 349 | Phosphotyrosine; by CSKBy similarity | 1 | |
Modified residuei | 354 | Phosphotyrosine; by CSKBy similarity | 1 | |
Modified residuei | 355 | Phosphotyrosine; by CSK and TNK2By similarity | 1 | |
Cross-linki | 378 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity | ||
Modified residuei | 385 | Phosphotyrosine; by CSKBy similarity | 1 | |
Cross-linki | 497 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity | ||
Modified residuei | 511 | Phosphotyrosine; by CSKBy similarity | 1 | |
Modified residuei | 528 | Phosphotyrosine; by CSKBy similarity | 1 | |
Modified residuei | 627 | Phosphoserine; by STK4/MST1By similarity | 1 | |
Cross-linki | 822 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 824 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Modified residuei | 892 | Phosphotyrosine; by CSKBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q9GKL7 |
Interactioni
Subunit structurei
Binds DNA as a homodimer.
Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7.
Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone.
Interacts with EFCAB6/DJBP, PELP1, PQBP1, RANBP9, RBAK, SPDEF, SRA1, TGFB1I1 and RREB1.
Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its transactivation activity.
Interacts with SLC30A9 and RAD54L2/ARIP4.
Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from NCOA1, NCOA2, NCOA3, NCOA4 and MAGEA11. The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR-mediated transactivation. Ran-binding decreases as the poly-Gln length increases.
Interacts with HIP1 (via coiled coil domain).
Interacts (via ligand-binding domain) with TRIM68.
Interacts with TNK2.
Interacts with USP26.
Interacts with RNF6.
Interacts (regulated by RNF6 probably through polyubiquitination) with RNF14; regulates AR transcriptional activity.
Interacts with PRMT2 and TRIM24.
Interacts with RACK1.
Interacts with RANBP10; this interaction enhances dihydrotestosterone-induced AR transcriptional activity.
Interacts with PRPF6 in a hormone-independent way; this interaction enhances dihydrotestosterone-induced AR transcriptional activity.
Interacts with STK4/MST1.
Interacts with ZIPK/DAPK3.
Interacts with LPXN.
Interacts with MAK.
Part of a complex containing AR, MAK and NCOA3.
Interacts with CRY1.
Interacts with CCAR1 and GATA2.
Interacts with ZNF318.
Interacts with BUD31.
Interacts with ARID4A.
Interacts with ARID4B.
Interacts (via NR LBD domain) with ZBTB7A; the interaction is direct and androgen-dependent (By similarity).
Interacts with NCOR1 (By similarity).
Interacts with NCOR2 (By similarity).
Interacts with CRY2 in a ligand-dependent manner (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 697 | Interaction with coactivator LXXL and FXXFY motifsBy similarity | 1 | |
Sitei | 874 | Interaction with coactivator FXXLF and FXXFY motifsBy similarity | 1 |
GO - Molecular functioni
- beta-catenin binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000013166 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 645 – 876 | NR LBDPROSITE-ProRule annotationAdd BLAST | 232 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 563 | Interaction with ZNF318By similarityAdd BLAST | 563 | |
Regioni | 1 – 534 | ModulatingBy similarityAdd BLAST | 534 | |
Regioni | 528 – 895 | Interaction with LPXNBy similarityAdd BLAST | 368 | |
Regioni | 548 – 638 | Interaction with HIPK3By similarityAdd BLAST | 91 | |
Regioni | 568 – 895 | Interaction with CCAR1By similarityAdd BLAST | 328 | |
Regioni | 601 – 895 | Interaction with KAT7By similarityAdd BLAST | 295 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 55 – 62 | Poly-Gln | 8 | |
Compositional biasi | 69 – 75 | Poly-Gln | 7 | |
Compositional biasi | 180 – 189 | Poly-Gln | 10 | |
Compositional biasi | 364 – 373 | Poly-Pro | 10 | |
Compositional biasi | 388 – 394 | Poly-Ala | 7 | |
Compositional biasi | 441 – 446 | Poly-Gly | 6 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 536 – 556 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 572 – 596 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
InParanoidi | Q9GKL7 |
OrthoDBi | 615449at2759 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR001103, Andrgn_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF02166, Androgen_recep, 1 hit PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00521, ANDROGENR PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MEVQLGLGRV YPRPPSKTFR GAFQNLFQSV REVIQNPGPR HPEAASAAPP
60 70 80 90 100
GARLQQQQLQ QQETSPRRQQ QQQQQPSEDG SPQVQSRGPT GYLALDEKQQ
110 120 130 140 150
PSQQQSAPEC HPESGCTPEP GAASAASKGL QQQPPAPPDE DDSAAPSTLS
160 170 180 190 200
LLGPTFPGLS SCSTDLKDIL SEAGTMQLLQ QQQQQQQQQE AVSEGNSSGR
210 220 230 240 250
AREATGAPIS SKDSYLGGSS TISDSAKELC KAVSVSMGLG VEALEHLSPG
260 270 280 290 300
EQLRGDCMYA PLLTGPPSVR PTPCAPLAEC KGSLLDDGPG KSNEETAEYS
310 320 330 340 350
PFKAGYTKGL DSESLGCSSG GEAGGSGTLE LPSALSLYKS GALDDVAAYP
360 370 380 390 400
SRDYYNFPLA LAGPPPPPPP PHPHARIKLE NPLDYGSAWA AAAAQCRYGD
410 420 430 440 450
LASLHGGGAP GPGSGSPSAT SSSSWHTLFT AEESQLYGPC GGGGGGSAGE
460 470 480 490 500
AGAVAPYGYT RPPQGLAGQE GDLAIPDIWY PGGVVSRVPY PSPSCVKSEM
510 520 530 540 550
GPWMESYSGP YGDMRLEPTR DHVLPIDYYF PPQKTCLICG DEASGCHYGA
560 570 580 590 600
LTCGSCKVFF KRAAEGKQKY LCASRNDCTI DKFRRKNCPS CRLRKCYEAG
610 620 630 640 650
MTLGARKLKK LGNLKLQEEG EASSATSPTE EPAQKLTVSH IEGYECQPIF
660 670 680 690 700
LNVLEAIEPG VVCAGHDNNQ PDSFAALLSS LNELGERQLV HVVKWAKALP
710 720 730 740 750
GFRNLHVDDQ MAVIQYSWMG LMVFAMGWRS FTNVNSRMLY FAPDLVFNEY
760 770 780 790 800
RMHKSRMYSQ CVRMRHLSQE FGWLQITPQE FLCMKALLLF SIIPVDGLKN
810 820 830 840 850
QKFFDELRMN YIKELDRIIA CKRKNPTSCS RRFYQLTKLL DSVQPIAREL
860 870 880 890
HQFTFDLLIK SHMVSVDFPE MMAEIISVQV PKILSGKVKP IYFHTQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | R → W in AAG40566 (PubMed:11086548).Curated | 1 | |
Sequence conflicti | 75 | Missing in AAG40566 (PubMed:11086548).Curated | 1 | |
Sequence conflicti | 256 | D → G in AAG40566 (PubMed:11086548).Curated | 1 | |
Sequence conflicti | 323 | A → E in AAG40566 (PubMed:11086548).Curated | 1 | |
Sequence conflicti | 352 | R → N in AAG37994 (Ref. 1) Curated | 1 | |
Sequence conflicti | 363 | G → R in AAG40566 (PubMed:11086548).Curated | 1 | |
Sequence conflicti | 410 | P → S in AAG40566 (PubMed:11086548).Curated | 1 | |
Sequence conflicti | 820 – 823 | ACKR → VMQE in AAG40566 (PubMed:11086548).Curated | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF202775 mRNA Translation: AAG37994.1 AF161717 mRNA Translation: AAG40566.1 |
RefSeqi | NP_999479.2, NM_214314.2 |
Genome annotation databases
GeneIDi | 397582 |
KEGGi | ssc:397582 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF202775 mRNA Translation: AAG37994.1 AF161717 mRNA Translation: AAG40566.1 |
RefSeqi | NP_999479.2, NM_214314.2 |
3D structure databases
SMRi | Q9GKL7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000013166 |
Proteomic databases
PaxDbi | Q9GKL7 |
Genome annotation databases
GeneIDi | 397582 |
KEGGi | ssc:397582 |
Organism-specific databases
CTDi | 367 |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
InParanoidi | Q9GKL7 |
OrthoDBi | 615449at2759 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR001103, Andrgn_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF02166, Androgen_recep, 1 hit PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00521, ANDROGENR PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANDR_PIG | |
Accessioni | Q9GKL7Primary (citable) accession number: Q9GKL7 Secondary accession number(s): Q9GKN9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2004 |
Last sequence update: | July 13, 2010 | |
Last modified: | April 7, 2021 | |
This is version 142 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families