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Protein

HLA class II histocompatibility antigen, DRB1-14 beta chain

Gene

HLA-DRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-2132295 MHC class II antigen presentation
R-HSA-389948 PD-1 signaling
R-HSA-877300 Interferon gamma signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DRB1-14 beta chain
Alternative name(s):
MHC class II antigen DRB1*14
Short name:
DR-14
Short name:
DR14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000196126.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4948 HLA-DRB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142857 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9GIY3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei228 – 248HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3123

MalaCards human disease database

More...
MalaCardsi
HLA-DRB1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3988561

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HLA-DRB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761361

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500006667630 – 266HLA class II histocompatibility antigen, DRB1-14 beta chainAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi146 ↔ 202PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9GIY3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9GIY3

PeptideAtlas

More...
PeptideAtlasi
Q9GIY3

PRoteomics IDEntifications database

More...
PRIDEi
Q9GIY3

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1372

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9GIY3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196126 Expressed in 94 organ(s), highest expression level in spleen

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9GIY3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9GIY3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB015400
CAB034021

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9GIY3, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9GIY3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9GIY3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 214Ig-like C1-typeAdd BLAST89

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG012730

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.10.320.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All

Q9GIY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TSECHFFNGT
60 70 80 90 100
ERVRFLDRYF HNQEEFVRFD SDVGEYRAVT ELGRPAAEHW NSQKDLLERR
110 120 130 140 150
RAEVDTYCRH NYGVVESFTV QRRVHPKVTV YPSKTQPLQH YNLLVCSVSG
160 170 180 190 200
FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG DWTFQTLVML ETVPRSGEVY
210 220 230 240 250
TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF
260
RNQKGHSGLQ PRGFLS
Length:266
Mass (Da):30,139
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA4BE90DFAB4FA55
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P137602B14_HUMAN
HLA class II histocompatibility ant...
HLA-DRB1
266Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P042292B11_HUMAN
HLA class II histocompatibility ant...
HLA-DRB1
266Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P137612B17_HUMAN
HLA class II histocompatibility ant...
HLA-DRB1
266Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5Y7A72B1D_HUMAN
HLA class II histocompatibility ant...
HLA-DRB1
266Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P019112B1F_HUMAN
HLA class II histocompatibility ant...
HLA-DRB1 HLA-DRB2
266Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P019122B13_HUMAN
HLA class II histocompatibility ant...
HLA-DRB1
266Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q299742B1G_HUMAN
HLA class II histocompatibility ant...
HLA-DRB1
266Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9TQE02B19_HUMAN
HLA class II histocompatibility ant...
HLA-DRB1
266Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q95IE32B1C_HUMAN
HLA class II histocompatibility ant...
HLA-DRB1
266Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P200392B1B_HUMAN
HLA class II histocompatibility ant...
HLA-DRB1
266Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB45249 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti124V → G in BAH23562 (Ref. 10) Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The following alleles of DRB1-14 are known: DRB1*14:01, DRB1*14:02, DRB1*14:03, DRB1*14:04, DRB1*14:05, DRB1*14:06, DRB1*14:07, DRB1*14:08, DRB1*14:09, DRB1*14:10, DRB1*14:11, DRB1*14:12, DRB1*14:13, DRB1*14:14, DRB1*14:15, DRB1*14:16, DRB1*14:17, DRB1*14:18, DRB1*14:19, DRB1*14:20, DRB1*14:21, DRB1*14:22, DRB1*14:23, DRB1*14:24, DRB1*14:25, DRB1*14:26, DRB1*14:27, DRB1*14:28, DRB1*14:29, DRB1*14:30, DRB1*14:31, DRB1*14:32, DRB1*14:33, DRB1*14:34, DRB1*14:35, DRB1*14:36, DRB1*14:37, DRB1*14:38, DRB1*14:39, DRB1*14:40, DRB1*14:41, DRB1*14:42, DRB1*14:43, DRB1*14:44, DRB1*14:45, DRB1*14:46, DRB1*14:47, DRB1*14:48, DRB1*14:49, DRB1*14:50, DRB1*14:51, DRB1*14:52, DRB1*14:53, DRB1*14:54, DRB1*14:55, DRB1*14:56, DRB1*14:57, DRB1*14:58, DRB1*14:59, DRB1*14:60, DRB1*14:61, DRB1*14:62, DRB1*14:63, DRB1*14:64, DRB1*14:65, DRB1*14:67, DRB1*14:68, DRB1*14:69, DRB1*14:70, DRB1*14:71, DRB1*14:72, DRB1*14:73, DRB1*14:74, DRB1*14:75, DRB1*14:76, DRB1*14:77, DRB1*14:78, DRB1*14:79, DRB1*14:80, DRB1*14:81, DRB1*14:82, DRB1*14:83, DRB1*14:84 and DRB1*14:85. The sequence shown is that of DRB1*14:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06290739Y → L in allele DRB1*14:46; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06290639Y → Q in allele DRB1*14:10 and allele DRB1*14:57; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06291040S → P in allele DRB1*14:39. 1
Natural variantiVAR_06290840S → R in allele DRB1*14:46. 1
Natural variantiVAR_06290940S → V in allele DRB1*14:10 and allele DRB1*14:57; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06291141T → K in allele DRB1*14:10, allele DRB1*14:46 and allele DRB1*14:57. 1
Natural variantiVAR_06291342S → G in allele DRB1*14:04, allele DRB1*14:11, allele DRB1*14:15, allele DRB1*14:28, allele DRB1*14:31, allele DRB1*14:50, allele DRB1*14:52, allele DRB1*14:61, allele DRB1*14:68, allele DRB1*14:71, allele DRB1*14:73, allele DRB1*14:76 and allele DRB1*14:79. 1
Natural variantiVAR_06291242S → H in allele DRB1*14:10 and allele DRB1*14:57; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06291545H → Q in allele DRB1*14:05, allele DRB1*14:37, allele DRB1*14:43, allele DRB1*14:44, allele DRB1*14:45, allele DRB1*14:56 and allele DRB1*14:84. 1
Natural variantiVAR_06291445H → Y in allele DRB1*14:04, allele DRB1*14:11, allele DRB1*14:15, allele DRB1*14:28, allele DRB1*14:31, allele DRB1*14:50, allele DRB1*14:52, allele DRB1*14:68, allele DRB1*14:71, allele DRB1*14:73, allele DRB1*14:76 and allele DRB1*14:79. 1
Natural variantiVAR_06291654R → Q in allele DRB1*14:26. 1
Natural variantiVAR_06291755F → Y in allele DRB1*14:82. 1
Natural variantiVAR_06291856L → M in allele DRB1*14:83. 1
Natural variantiVAR_06291957D → E in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:06, allele DRB1*14:12, allele DRB1*14:13, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:81, allele DRB1*14:83 and allele DRB1*14:85. 1
Natural variantiVAR_06292059Y → H in allele DRB1*14:70. 1
Natural variantiVAR_06292161H → Y in allele DRB1*14:25, allele DRB1*14:42, allele DRB1*14:53, allele DRB1*14:58 and allele DRB1*14:69. 1
Natural variantiVAR_06292366F → N in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:12, allele DRB1*14:13, allele DRB1*14:17, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:21, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:59, allele DRB1*14:63, allele DRB1*14:64, allele DRB1*14:67, allele DRB1*14:78, allele DRB1*14:80, allele DRB1*14:81, allele DRB1*14:83 and allele DRB1*14:85; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06292266F → Y in allele DRB1*14:25, allele DRB1*14:42, allele DRB1*14:53, allele DRB1*14:58 and allele DRB1*14:69. 1
Natural variantiVAR_06292467V → L in allele DRB1*14:41 and allele DRB1*14:77. 1
Natural variantiVAR_06292574G → R in allele DRB1*14:36 and allele DRB1*14:60. 1
Natural variantiVAR_06292676Y → F in allele DRB1*14:17, allele DRB1*14:21, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:35, allele DRB1*14:42, allele DRB1*14:53, allele DRB1*14:64, allele DRB1*14:65 and allele DRB1*14:72. 1
Natural variantiVAR_06292780T → R in allele DRB1*14:59. 1
Natural variantiVAR_06292886A → D in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:05, allele DRB1*14:06, allele DRB1*14:08, allele DRB1*14:09, allele DRB1*14:11, allele DRB1*14:12, allele DRB1*14:14, allele DRB1*14:15, allele DRB1*14:17, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:23, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:34, allele DRB1*14:36, allele DRB1*14:37, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:42, allele DRB1*14:43, allele DRB1*14:44, allele DRB1*14:45, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:56, allele DRB1*14:59, allele DRB1*14:64, allele DRB1*14:67, allele DRB1*14:72, allele DRB1*14:77, allele DRB1*14:80, allele DRB1*14:81, allele DRB1*14:83 and allele DRB1*14:84. 1
Natural variantiVAR_06292986A → S in allele DRB1*14:13, allele DRB1*14:63, allele DRB1*14:65, allele DRB1*14:78 and allele DRB1*14:85. 1
Natural variantiVAR_06293086A → T in allele DRB1*14:62. 1
Natural variantiVAR_06293186A → V in allele DRB1*14:48. 1
Natural variantiVAR_06293287A → E in allele DRB1*14:11. 1
Natural variantiVAR_06293489H → S in allele DRB1*14:48 and allele DRB1*14:64; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06293389H → Y in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:05, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:11, allele DRB1*14:12, allele DRB1*14:13, allele DRB1*14:14, allele DRB1*14:15, allele DRB1*14:17, allele DRB1*14:18, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:23, allele DRB1*14:24, allele DRB1*14:27, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:36, allele DRB1*14:37, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:42, allele DRB1*14:43, allele DRB1*14:44, allele DRB1*14:45, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:56, allele DRB1*14:57, allele DRB1*14:59, allele DRB1*14:63, allele DRB1*14:65, allele DRB1*14:67, allele DRB1*14:76, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:80, allele DRB1*14:81, allele DRB1*14:83, allele DRB1*14:84 and allele DRB1*14:85. 1
Natural variantiVAR_06293596L → F in allele DRB1*14:15, allele DRB1*14:22, allele DRB1*14:25, allele DRB1*14:27, allele DRB1*14:53 and allele DRB1*14:73. 1
Natural variantiVAR_06293696L → I in allele DRB1*14:16, allele DRB1*14:24, allele DRB1*14:37, allele DRB1*14:45, allele DRB1*14:57, allele DRB1*14:63, allele DRB1*14:67 and allele DRB1*14:78. 1
Natural variantiVAR_06293899R → D in allele DRB1*14:03, allele DRB1*14:12, allele DRB1*14:15, allele DRB1*14:16, allele DRB1*14:22, allele DRB1*14:25, allele DRB1*14:27, allele DRB1*14:40, allele DRB1*14:53, allele DRB1*14:57, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:69, allele DRB1*14:73, allele DRB1*14:74, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:84 and allele DRB1*14:85; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06293799R → Q in allele DRB1*14:02, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:13, allele DRB1*14:17, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:24, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:33, allele DRB1*14:37, allele DRB1*14:41, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:51, allele DRB1*14:52, allele DRB1*14:76, allele DRB1*14:79, allele DRB1*14:80 and allele DRB1*14:83. 1
Natural variantiVAR_062941100R → A in allele DRB1*14:24 and allele DRB1*14:37; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062940100R → E in allele DRB1*14:16 and allele DRB1*14:57; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062939100R → K in allele DRB1*14:19, allele DRB1*14:21, allele DRB1*14:76 and allele DRB1*14:79. 1
Natural variantiVAR_062943102A → G in allele DRB1*14:76 and allele DRB1*14:79. 1
Natural variantiVAR_062942102A → S in allele DRB1*14:56. 1
Natural variantiVAR_062944103E → A in allele DRB1*14:02, allele DRB1*14:06, allele DRB1*14:09, allele DRB1*14:13, allele DRB1*14:16, allele DRB1*14:17, allele DRB1*14:19, allele DRB1*14:20, allele DRB1*14:21, allele DRB1*14:22, allele DRB1*14:24, allele DRB1*14:25, allele DRB1*14:29, allele DRB1*14:30, allele DRB1*14:31, allele DRB1*14:32, allele DRB1*14:34, allele DRB1*14:37, allele DRB1*14:41, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:52, allele DRB1*14:53, allele DRB1*14:57, allele DRB1*14:65, allele DRB1*14:69, allele DRB1*14:74, allele DRB1*14:80, allele DRB1*14:81 and allele DRB1*14:83. 1
Natural variantiVAR_062945103E → L in allele DRB1*14:03, allele DRB1*14:12, allele DRB1*14:15, allele DRB1*14:27, allele DRB1*14:40, allele DRB1*14:55, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:77, allele DRB1*14:78, allele DRB1*14:84 and allele DRB1*14:85; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062946103E → R in allele DRB1*14:76 and allele DRB1*14:79; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062948106T → A in allele DRB1*14:43. 1
Natural variantiVAR_062947106T → N in allele DRB1*14:38, allele DRB1*14:47, allele DRB1*14:50, allele DRB1*14:76 and allele DRB1*14:79. 1
Natural variantiVAR_062949110H → Y in allele DRB1*14:75. 1
Natural variantiVAR_062950114V → A in allele DRB1*14:28 and allele DRB1*14:29. 1
Natural variantiVAR_062951115V → G in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:07, allele DRB1*14:09, allele DRB1*14:13, allele DRB1*14:14, allele DRB1*14:19, allele DRB1*14:22, allele DRB1*14:24, allele DRB1*14:25, allele DRB1*14:27, allele DRB1*14:30, allele DRB1*14:36, allele DRB1*14:40, allele DRB1*14:41, allele DRB1*14:42, allele DRB1*14:44, allele DRB1*14:46, allele DRB1*14:47, allele DRB1*14:48, allele DRB1*14:49, allele DRB1*14:51, allele DRB1*14:53, allele DRB1*14:63, allele DRB1*14:67, allele DRB1*14:68, allele DRB1*14:69, allele DRB1*14:77 and allele DRB1*14:85. 1
Natural variantiVAR_062952115V → M in allele DRB1*14:71. 1
Natural variantiVAR_062953141Y → H in allele DRB1*14:02, allele DRB1*14:03, allele DRB1*14:04, allele DRB1*14:05, allele DRB1*14:06, allele DRB1*14:07, allele DRB1*14:10, allele DRB1*14:11, allele DRB1*14:13, allele DRB1*14:14, allele DRB1*14:21, allele DRB1*14:46, allele DRB1*14:54, allele DRB1*14:57 and allele DRB1*14:82. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB062112 mRNA Translation: BAB84521.2
AJ297582 mRNA Translation: CAC08822.1
AJ297583 mRNA Translation: CAC08823.1
AJ297584 mRNA Translation: CAC08824.1
AJ297585 mRNA Translation: CAC08825.1
AY663408 Genomic DNA Translation: AAU88014.1
AY935719 mRNA Translation: AAX33315.1
AY961071 mRNA Translation: AAX63459.2
DQ235685 Genomic DNA Translation: ABB52004.1
DQ390459 Genomic DNA Translation: ABD60300.1
DQ390460 Genomic DNA Translation: ABD60301.1
FJ379259 Genomic DNA Translation: ACJ06537.1
Z38072 Genomic DNA Translation: CAA86217.1
FM196525 Genomic DNA Translation: CAQ86516.1
AM109998 Genomic DNA Translation: CAJ33605.1
AM109999 Genomic DNA Translation: CAJ33606.1
AM110000 Genomic DNA Translation: CAJ33607.1
AM110001 Genomic DNA Translation: CAJ33608.1
AM110002 Genomic DNA Translation: CAJ33609.1
AM110003 Genomic DNA Translation: CAJ33610.1
AB485773 Genomic DNA Translation: BAH23562.1
Z50730 Genomic DNA No translation available.
AJ242985 Genomic DNA Translation: CAB45249.1 Sequence problems.
AJ251985 Genomic DNA Translation: CAC19086.1
AY050186 Genomic DNA Translation: AAL23547.1
AY054375 mRNA Translation: AAL15169.1
AF400066 Genomic DNA Translation: AAK85431.1
AY267905 Genomic DNA Translation: AAP32696.1
AY267906 Genomic DNA Translation: AAP32697.1
AJ969417 Genomic DNA Translation: CAI94542.1
AY912075 Genomic DNA Translation: AAY17288.1
DQ333353 Genomic DNA Translation: ABC59115.1
AM259285 Genomic DNA Translation: CAJ90660.1
EF199810 Genomic DNA Translation: ABM90423.1
AM774161 Genomic DNA Translation: CAO81738.1
EF495154 Genomic DNA Translation: ABP38039.1
AM922324 Genomic DNA Translation: CAP58300.1
DQ494324 Genomic DNA Translation: ABF50050.1
EU588391 Genomic DNA Translation: ACB97664.1
D86502 Genomic DNA Translation: BAA13097.1
D86504 Genomic DNA Translation: BAA13099.1
D88310 Genomic DNA Translation: BAA13587.1
AJ010982 Genomic DNA Translation: CAA09450.1
AF172071 Genomic DNA Translation: AAD51970.1
AJ543433 Genomic DNA Translation: CAD65908.1
AY277390 Genomic DNA Translation: AAP34694.1
AJ581744 Genomic DNA Translation: CAE46451.1
AJ812566 Genomic DNA Translation: CAH23708.1
AY770520 Genomic DNA Translation: AAV37191.1
DQ021915 Genomic DNA Translation: AAY85747.1
AM084908 Genomic DNA Translation: CAJ29895.1
DQ327711 Genomic DNA Translation: ABC59293.1
DQ358688 Genomic DNA Translation: ABC84557.1
AM233907 Genomic DNA Translation: CAJ80873.1
DQ643390 Genomic DNA Translation: ABG25965.1
U95115 Genomic DNA Translation: AAB58397.2
AM933133 Genomic DNA Translation: CAP69806.1
EU545181 Genomic DNA Translation: ACB30275.1
AB049830 Genomic DNA Translation: BAB16682.1
AB049831 Genomic DNA Translation: BAB16683.1
AB049832 Genomic DNA Translation: BAB16684.1
AB087875 Genomic DNA Translation: BAC02938.1
AB087876 Genomic DNA Translation: BAC02939.1
AB436778 Genomic DNA Translation: BAG32234.1
EF078986 Genomic DNA Translation: ABK56696.1
EF536016 Genomic DNA Translation: ABQ08747.1
EU029787 Genomic DNA Translation: ABU86846.1
EU029788 Genomic DNA Translation: ABU86847.1
EU029792 Genomic DNA Translation: ABU86851.1
EU029793 Genomic DNA Translation: ABU86852.1
EU029798 Genomic DNA Translation: ABU86857.1
EU643616 Genomic DNA Translation: ACD01094.1
EU812536 Genomic DNA Translation: ACE88696.1
EU924810 Genomic DNA Translation: ACH57405.1
DQ060439 Genomic DNA Translation: AAY59541.1
DQ060441 Genomic DNA Translation: AAY59543.1
DQ782331 Genomic DNA Translation: ABG91054.1
FM179681 Genomic DNA Translation: CAQ77159.1
FJ594768 Genomic DNA Translation: ACM47962.1
AF177215 Genomic DNA Translation: AAD53910.1
X99839 Genomic DNA Translation: CAA68150.1
AJ289123 Genomic DNA Translation: CAC19015.1
AY174092 Genomic DNA Translation: AAO20089.1
AY174181 Genomic DNA Translation: AAO17053.1
M77673 Genomic DNA Translation: AAA73131.1
AF028010 Genomic DNA Translation: AAB94612.1
AF112879 Genomic DNA Translation: AAD29584.1
X86974 Genomic DNA No translation available.
U41489 Genomic DNA Translation: AAA86242.1
AJ508388 Genomic DNA Translation: CAD48196.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B33287
C33287
C60748
F60748
PH0157
PH0158
S03440

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.485130
Hs.534322
Hs.696211
Hs.716081
Hs.723344
Hs.736560

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000328980; ENSP00000331343; ENSG00000206306
ENST00000360004; ENSP00000353099; ENSG00000196126
ENST00000399450; ENSP00000382378; ENSG00000206240
ENST00000412634; ENSP00000408795; ENSG00000228080
ENST00000415796; ENSP00000412168; ENSG00000206306
ENST00000419393; ENSP00000403458; ENSG00000228080
ENST00000428566; ENSP00000392280; ENSG00000206240

UCSC genome browser

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UCSCi
uc063uqx.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062112 mRNA Translation: BAB84521.2
AJ297582 mRNA Translation: CAC08822.1
AJ297583 mRNA Translation: CAC08823.1
AJ297584 mRNA Translation: CAC08824.1
AJ297585 mRNA Translation: CAC08825.1
AY663408 Genomic DNA Translation: AAU88014.1
AY935719 mRNA Translation: AAX33315.1
AY961071 mRNA Translation: AAX63459.2
DQ235685 Genomic DNA Translation: ABB52004.1
DQ390459 Genomic DNA Translation: ABD60300.1
DQ390460 Genomic DNA Translation: ABD60301.1
FJ379259 Genomic DNA Translation: ACJ06537.1
Z38072 Genomic DNA Translation: CAA86217.1
FM196525 Genomic DNA Translation: CAQ86516.1
AM109998 Genomic DNA Translation: CAJ33605.1
AM109999 Genomic DNA Translation: CAJ33606.1
AM110000 Genomic DNA Translation: CAJ33607.1
AM110001 Genomic DNA Translation: CAJ33608.1
AM110002 Genomic DNA Translation: CAJ33609.1
AM110003 Genomic DNA Translation: CAJ33610.1
AB485773 Genomic DNA Translation: BAH23562.1
Z50730 Genomic DNA No translation available.
AJ242985 Genomic DNA Translation: CAB45249.1 Sequence problems.
AJ251985 Genomic DNA Translation: CAC19086.1
AY050186 Genomic DNA Translation: AAL23547.1
AY054375 mRNA Translation: AAL15169.1
AF400066 Genomic DNA Translation: AAK85431.1
AY267905 Genomic DNA Translation: AAP32696.1
AY267906 Genomic DNA Translation: AAP32697.1
AJ969417 Genomic DNA Translation: CAI94542.1
AY912075 Genomic DNA Translation: AAY17288.1
DQ333353 Genomic DNA Translation: ABC59115.1
AM259285 Genomic DNA Translation: CAJ90660.1
EF199810 Genomic DNA Translation: ABM90423.1
AM774161 Genomic DNA Translation: CAO81738.1
EF495154 Genomic DNA Translation: ABP38039.1
AM922324 Genomic DNA Translation: CAP58300.1
DQ494324 Genomic DNA Translation: ABF50050.1
EU588391 Genomic DNA Translation: ACB97664.1
D86502 Genomic DNA Translation: BAA13097.1
D86504 Genomic DNA Translation: BAA13099.1
D88310 Genomic DNA Translation: BAA13587.1
AJ010982 Genomic DNA Translation: CAA09450.1
AF172071 Genomic DNA Translation: AAD51970.1
AJ543433 Genomic DNA Translation: CAD65908.1
AY277390 Genomic DNA Translation: AAP34694.1
AJ581744 Genomic DNA Translation: CAE46451.1
AJ812566 Genomic DNA Translation: CAH23708.1
AY770520 Genomic DNA Translation: AAV37191.1
DQ021915 Genomic DNA Translation: AAY85747.1
AM084908 Genomic DNA Translation: CAJ29895.1
DQ327711 Genomic DNA Translation: ABC59293.1
DQ358688 Genomic DNA Translation: ABC84557.1
AM233907 Genomic DNA Translation: CAJ80873.1
DQ643390 Genomic DNA Translation: ABG25965.1
U95115 Genomic DNA Translation: AAB58397.2
AM933133 Genomic DNA Translation: CAP69806.1
EU545181 Genomic DNA Translation: ACB30275.1
AB049830 Genomic DNA Translation: BAB16682.1
AB049831 Genomic DNA Translation: BAB16683.1
AB049832 Genomic DNA Translation: BAB16684.1
AB087875 Genomic DNA Translation: BAC02938.1
AB087876 Genomic DNA Translation: BAC02939.1
AB436778 Genomic DNA Translation: BAG32234.1
EF078986 Genomic DNA Translation: ABK56696.1
EF536016 Genomic DNA Translation: ABQ08747.1
EU029787 Genomic DNA Translation: ABU86846.1
EU029788 Genomic DNA Translation: ABU86847.1
EU029792 Genomic DNA Translation: ABU86851.1
EU029793 Genomic DNA Translation: ABU86852.1
EU029798 Genomic DNA Translation: ABU86857.1
EU643616 Genomic DNA Translation: ACD01094.1
EU812536 Genomic DNA Translation: ACE88696.1
EU924810 Genomic DNA Translation: ACH57405.1
DQ060439 Genomic DNA Translation: AAY59541.1
DQ060441 Genomic DNA Translation: AAY59543.1
DQ782331 Genomic DNA Translation: ABG91054.1
FM179681 Genomic DNA Translation: CAQ77159.1
FJ594768 Genomic DNA Translation: ACM47962.1
AF177215 Genomic DNA Translation: AAD53910.1
X99839 Genomic DNA Translation: CAA68150.1
AJ289123 Genomic DNA Translation: CAC19015.1
AY174092 Genomic DNA Translation: AAO20089.1
AY174181 Genomic DNA Translation: AAO17053.1
M77673 Genomic DNA Translation: AAA73131.1
AF028010 Genomic DNA Translation: AAB94612.1
AF112879 Genomic DNA Translation: AAD29584.1
X86974 Genomic DNA No translation available.
U41489 Genomic DNA Translation: AAA86242.1
AJ508388 Genomic DNA Translation: CAD48196.1
PIRiB33287
C33287
C60748
F60748
PH0157
PH0158
S03440
UniGeneiHs.485130
Hs.534322
Hs.696211
Hs.716081
Hs.723344
Hs.736560

3D structure databases

ProteinModelPortaliQ9GIY3
SMRiQ9GIY3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9GIY3, 1 interactor

Chemistry databases

ChEMBLiCHEMBL3988561

PTM databases

GlyConnecti1372
SwissPalmiQ9GIY3

Polymorphism and mutation databases

BioMutaiHLA-DRB1
DMDMi74761361

Proteomic databases

EPDiQ9GIY3
jPOSTiQ9GIY3
PeptideAtlasiQ9GIY3
PRIDEiQ9GIY3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328980; ENSP00000331343; ENSG00000206306
ENST00000360004; ENSP00000353099; ENSG00000196126
ENST00000399450; ENSP00000382378; ENSG00000206240
ENST00000412634; ENSP00000408795; ENSG00000228080
ENST00000415796; ENSP00000412168; ENSG00000206306
ENST00000419393; ENSP00000403458; ENSG00000228080
ENST00000428566; ENSP00000392280; ENSG00000206240
UCSCiuc063uqx.1 human

Organism-specific databases

DisGeNETi3123
EuPathDBiHostDB:ENSG00000196126.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HLA-DRB1
HGNCiHGNC:4948 HLA-DRB1
HPAiCAB015400
CAB034021
MalaCardsiHLA-DRB1
MIMi142857 gene
neXtProtiNX_Q9GIY3

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

HOVERGENiHBG012730

Enzyme and pathway databases

ReactomeiR-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-2132295 MHC class II antigen presentation
R-HSA-389948 PD-1 signaling
R-HSA-877300 Interferon gamma signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HLA-DRB1 human

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196126 Expressed in 94 organ(s), highest expression level in spleen
ExpressionAtlasiQ9GIY3 baseline and differential
GenevisibleiQ9GIY3 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei2B1E_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GIY3
Secondary accession number(s): A0N0W1
, A2TGX3, A4ZY86, A5H000, A5HKN8, A7DZP9, A7X5B1, A7X5B7, A7X5E0, A7X5E6, A7X5H8, A9JPG0, B1GWE7, B2CR03, B2LVF9, B2NJ29, B2ZCY1, B3VTP8, B5B8U0, B5B9V5, B5LZ25, B6VEL9, B9VRA4, B9X248, O02876, O46793, O77969, O78210, Q0PQ39, Q155F7, Q1AP33, Q1JRP3, Q27PR6, Q27PR7, Q29734, Q29770, Q29772, Q29800, Q2A120, Q2HZE5, Q2LE76, Q2MJA6, Q2VQU1, Q307W5, Q31636, Q3LA87, Q3LA88, Q3LA89, Q3LA90, Q3LA91, Q3LA92, Q3T919, Q4PRC3, Q4PRC5, Q4VZY7, Q56FP1, Q5BM92, Q5U9W6, Q683P7, Q70GL2, Q7YNY9, Q7YQA5, Q860D8, Q860D9, Q860S0, Q861H5, Q861H7, Q8MH59, Q8MH60, Q8WLU3, Q95348, Q95HK1, Q95HL0, Q95IG2, Q9GIL5, Q9GIL6, Q9GIY0, Q9GIY1, Q9GIY2, Q9GJ56, Q9GJ57, Q9GJ58, Q9TPB6, Q9TPW1, Q9XRY4, Q9Y4H7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 1, 2001
Last modified: January 16, 2019
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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