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Entry version 114 (18 Sep 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Lupeol synthase 5

Gene

LUP5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional enzyme that converts oxidosqualene to tirucalla-7,21-diene-3beta-ol and two other triterpene monoalcohols.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei486Proton donorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lupeol synthase 5 (EC:5.4.99.-)
Short name:
AtLUP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LUP5
Ordered Locus Names:At1g66960
ORF Names:F1O19.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G66960

The Arabidopsis Information Resource

More...
TAIRi
locus:2019703 AT1G66960

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003661351 – 763Lupeol synthase 5Add BLAST763

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9FZI2

PRoteomics IDEntifications database

More...
PRIDEi
Q9FZI2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9FZI2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9FZI2 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT1G66960.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9FZI2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati149 – 190PFTB 1Add BLAST42
Repeati515 – 556PFTB 2Add BLAST42
Repeati592 – 632PFTB 3Add BLAST41
Repeati641 – 682PFTB 4Add BLAST42
Repeati703 – 744PFTB 5Add BLAST42

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0497 Eukaryota
COG1657 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234317

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9FZI2

KEGG Orthology (KO)

More...
KOi
K16208

Identification of Orthologs from Complete Genome Data

More...
OMAi
ALVIFKQ

Database of Orthologous Groups

More...
OrthoDBi
365003at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9FZI2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02892 SQCY_1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032696 SQ_cyclase_C
IPR032697 SQ_cyclase_N
IPR018333 Squalene_cyclase
IPR002365 Terpene_synthase_CS
IPR008930 Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13243 SQHop_cyclase_C, 1 hit
PF13249 SQHop_cyclase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239 SSF48239, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01787 squalene_cyclas, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01074 TERPENE_SYNTHASES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9FZI2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWRLKVGEGK GKDPYLFSSN NFVGRQTWEF DPKAGTREER TAVEEARRSF
60 70 80 90 100
FDNRSRVKPS SDLLWKMQFL KEAKFEQVIP PVKIDGGEAI TYEKATNALR
110 120 130 140 150
RGVAFLSALQ ASDGHWPGEF TGPLCMLPPL VFCLYITGHL EEVFDAEHRK
160 170 180 190 200
EMLRYIYCHQ NEDGGWGFHI ESKSIMFTTT LNYICLRILG VGPDGGLENA
210 220 230 240 250
CKRARQWILS HGGVIYIPCW GKVWLSVLGI YDWSGVNPMP PEIWLLPYFL
260 270 280 290 300
PIHLGKAFSY TRITYMPISY LYGKKFVGQI TPLIMQLREE LHLQPYEEIN
310 320 330 340 350
WNKARHLCAK EDKYYPHPLV QDLIWDALHT FVEPLLASWP INKLVRKKAL
360 370 380 390 400
QVAMKHIHYE DENSHYITIG CIEKNLCMLA CWIDNPDGNH FKKHLSRIPD
410 420 430 440 450
MMWVAEDGMK MQCFGSQLWM TGFAVQALLA SDPRDETYDV LRRAHDYIKK
460 470 480 490 500
SQVRDNPSGD FKSMYRHISK GGWTLSDRDH GWQVSDCTAE AAKCCMLLST
510 520 530 540 550
MPTDITGEKI NLEQLYDSVN LMLSLQSENG GFTAWEPVRA YKWMELMNPT
560 570 580 590 600
DLFANAMTER EYTECTSAVL QALVIFNQLY PDHRTKEITK SIEKAVQFIE
610 620 630 640 650
SKQLRDGSWY GSWGICFTYG TWFALCGLAA IGKTYNNCLS MRDGVHFLLN
660 670 680 690 700
IQNEDGGWGE SYMSCPEQRY IPLEGNRSNV VQTAWAMMAL IHAGQAKRDL
710 720 730 740 750
IPLHSAAKFI ITSQLENGDF PQQELLGASM STCMLHYSTY KDIFPPWALA
760
EYRKAAFIHH ADL
Length:763
Mass (Da):87,623
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4095EB93A64E6755
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8AW29A0A1P8AW29_ARATH
Terpene cyclase/mutase family membe...
LUP5 At1g66960, F1O19.4, F1O19_4
772Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF489920 mRNA Translation: AAN77001.1
AC007152 Genomic DNA Translation: AAF98208.1
CP002684 Genomic DNA Translation: AEE34578.1
CP002684 Genomic DNA Translation: ANM60852.1
CP002684 Genomic DNA Translation: ANM60854.1
AY062741 mRNA Translation: AAL32819.1
BT000138 mRNA Translation: AAN15457.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E96693

NCBI Reference Sequences

More...
RefSeqi
NP_001323105.1, NM_001334260.1
NP_001323107.1, NM_001334261.1
NP_176868.1, NM_105367.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G66960.1; AT1G66960.1; AT1G66960
AT1G66960.3; AT1G66960.3; AT1G66960
AT1G66960.4; AT1G66960.4; AT1G66960

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
843014

Gramene; a comparative resource for plants

More...
Gramenei
AT1G66960.1; AT1G66960.1; AT1G66960
AT1G66960.3; AT1G66960.3; AT1G66960
AT1G66960.4; AT1G66960.4; AT1G66960

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G66960

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF489920 mRNA Translation: AAN77001.1
AC007152 Genomic DNA Translation: AAF98208.1
CP002684 Genomic DNA Translation: AEE34578.1
CP002684 Genomic DNA Translation: ANM60852.1
CP002684 Genomic DNA Translation: ANM60854.1
AY062741 mRNA Translation: AAL32819.1
BT000138 mRNA Translation: AAN15457.1
PIRiE96693
RefSeqiNP_001323105.1, NM_001334260.1
NP_001323107.1, NM_001334261.1
NP_176868.1, NM_105367.3

3D structure databases

SMRiQ9FZI2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G66960.1

Proteomic databases

PaxDbiQ9FZI2
PRIDEiQ9FZI2

Genome annotation databases

EnsemblPlantsiAT1G66960.1; AT1G66960.1; AT1G66960
AT1G66960.3; AT1G66960.3; AT1G66960
AT1G66960.4; AT1G66960.4; AT1G66960
GeneIDi843014
GrameneiAT1G66960.1; AT1G66960.1; AT1G66960
AT1G66960.3; AT1G66960.3; AT1G66960
AT1G66960.4; AT1G66960.4; AT1G66960
KEGGiath:AT1G66960

Organism-specific databases

AraportiAT1G66960
TAIRilocus:2019703 AT1G66960

Phylogenomic databases

eggNOGiKOG0497 Eukaryota
COG1657 LUCA
HOGENOMiHOG000234317
InParanoidiQ9FZI2
KOiK16208
OMAiALVIFKQ
OrthoDBi365003at2759
PhylomeDBiQ9FZI2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9FZI2

Gene expression databases

ExpressionAtlasiQ9FZI2 baseline and differential
GenevisibleiQ9FZI2 AT

Family and domain databases

CDDicd02892 SQCY_1, 1 hit
InterProiView protein in InterPro
IPR032696 SQ_cyclase_C
IPR032697 SQ_cyclase_N
IPR018333 Squalene_cyclase
IPR002365 Terpene_synthase_CS
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF13243 SQHop_cyclase_C, 1 hit
PF13249 SQHop_cyclase_N, 1 hit
SUPFAMiSSF48239 SSF48239, 2 hits
TIGRFAMsiTIGR01787 squalene_cyclas, 1 hit
PROSITEiView protein in PROSITE
PS01074 TERPENE_SYNTHASES, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLUP5_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FZI2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 1, 2001
Last modified: September 18, 2019
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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