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UniProtKB - Q9FZ22 (GPAT2_ARATH)
Protein
Probable glycerol-3-phosphate acyltransferase 2
Gene
GPAT2
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.
By similarityCatalytic activityi
- EC:2.3.1.15
: CDP-diacylglycerol biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate. This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- glycerol-3-phosphate 2-O-acyltransferase activity Source: GO_Central
- glycerol-3-phosphate O-acyltransferase activity Source: UniProtKB-EC
- phosphatase activity Source: GO_Central
- sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity Source: UniProtKB-EC
GO - Biological processi
- CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
- cutin biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
BioCyci | ARA:AT1G02390-MONOMER |
BRENDAi | 2.3.1.15, 399 |
UniPathwayi | UPA00557;UER00612 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GPAT2 Ordered Locus Names:At1g02390 ORF Names:T6A9.17, T6A9.8 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G02390 |
TAIRi | locus:2204818, AT1G02390 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Note: Not mitochondrial.
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 70 – 90 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 93 – 113 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 275 – 295 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000195250 | 1 – 530 | Probable glycerol-3-phosphate acyltransferase 2Add BLAST | 530 |
Proteomic databases
PaxDbi | Q9FZ22 |
ProteomicsDBi | 248462 |
Expressioni
Tissue specificityi
Weakly or not expressed in roots, leaves, seedlings, developing siliques and flower buds.1 Publication
Gene expression databases
ExpressionAtlasi | Q9FZ22, baseline and differential |
Genevisiblei | Q9FZ22, AT |
Structurei
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 339 – 344 | HXXXXD motif | 6 |
Domaini
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity
Sequence similaritiesi
Belongs to the GPAT/DAPAT family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QRJ7, Eukaryota |
HOGENOMi | CLU_028504_1_0_1 |
InParanoidi | Q9FZ22 |
OMAi | PLFSEVC |
OrthoDBi | 855637at2759 |
PhylomeDBi | Q9FZ22 |
Family and domain databases
InterProi | View protein in InterPro IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF01553, Acyltransferase, 1 hit |
SMARTi | View protein in SMART SM00563, PlsC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9FZ22-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGNKISTLQ ALVFFLYRFF ILRRWCHRSP KQKYQKCPSH GLHQYQDLSN
60 70 80 90 100
HTLIFNVEGA LLKSNSLFPY FMVVAFEAGG VIRSLFLLVL YPFISLMSYE
110 120 130 140 150
MGLKTMVMLS FFGVKKESFR VGKSVLPKYF LEDVGLEMFQ VLKRGGKRVA
160 170 180 190 200
VSDLPQVMID VFLRDYLEIE VVVGRDMKMV GGYYLGIVED KKNLEIAFDK
210 220 230 240 250
VVQEERLGSG RRLIGITSFN SPSHRSLFSQ FCQEIYFVRN SDKKSWQTLP
260 270 280 290 300
QDQYPKPLIF HDGRLAVKPT PLNTLVLFMW APFAAVLAAA RLVFGLNLPY
310 320 330 340 350
SLANPFLAFS GIHLTLTVNN HNDLISADRK RGCLFVCNHR TLLDPLYISY
360 370 380 390 400
ALRKKNMKAV TYSLSRLSEL LAPIKTVRLT RDRVKDGQAM EKLLSQGDLV
410 420 430 440 450
VCPEGTTCRE PYLLRFSPLF SEVCDVIVPV AIDSHVTFFY GTTASGLKAF
460 470 480 490 500
DPIFFLLNPF PSYTVKLLDP VSGSSSSTCR GVPDNGKVNF EVANHVQHEI
510 520 530
GNALGFECTN LTRRDKYLIL AGNNGVVKKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC064879 Genomic DNA Translation: AAG00890.1 CP002684 Genomic DNA Translation: AEE27423.1 AF419560 mRNA Translation: AAL31892.1 AY097339 mRNA Translation: AAM19855.1 |
PIRi | C86154 |
RefSeqi | NP_563651.1, NM_100120.3 |
Genome annotation databases
EnsemblPlantsi | AT1G02390.1; AT1G02390.1; AT1G02390 |
GeneIDi | 839558 |
Gramenei | AT1G02390.1; AT1G02390.1; AT1G02390 |
KEGGi | ath:AT1G02390 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC064879 Genomic DNA Translation: AAG00890.1 CP002684 Genomic DNA Translation: AEE27423.1 AF419560 mRNA Translation: AAL31892.1 AY097339 mRNA Translation: AAM19855.1 |
PIRi | C86154 |
RefSeqi | NP_563651.1, NM_100120.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 3702.AT1G02390.1 |
Proteomic databases
PaxDbi | Q9FZ22 |
ProteomicsDBi | 248462 |
Genome annotation databases
EnsemblPlantsi | AT1G02390.1; AT1G02390.1; AT1G02390 |
GeneIDi | 839558 |
Gramenei | AT1G02390.1; AT1G02390.1; AT1G02390 |
KEGGi | ath:AT1G02390 |
Organism-specific databases
Araporti | AT1G02390 |
TAIRi | locus:2204818, AT1G02390 |
Phylogenomic databases
eggNOGi | ENOG502QRJ7, Eukaryota |
HOGENOMi | CLU_028504_1_0_1 |
InParanoidi | Q9FZ22 |
OMAi | PLFSEVC |
OrthoDBi | 855637at2759 |
PhylomeDBi | Q9FZ22 |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00612 |
BioCyci | ARA:AT1G02390-MONOMER |
BRENDAi | 2.3.1.15, 399 |
Miscellaneous databases
PROi | PR:Q9FZ22 |
Gene expression databases
ExpressionAtlasi | Q9FZ22, baseline and differential |
Genevisiblei | Q9FZ22, AT |
Family and domain databases
InterProi | View protein in InterPro IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF01553, Acyltransferase, 1 hit |
SMARTi | View protein in SMART SM00563, PlsC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GPAT2_ARATH | |
Accessioni | Q9FZ22Primary (citable) accession number: Q9FZ22 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families