UniProtKB - Q9FUR2 (IP5P2_ARATH)
Protein
Type I inositol polyphosphate 5-phosphatase 2
Gene
IP5P2
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Has phosphatase activity toward Ins(1,4,5)P3 and Ins(1,3,4,5)P4. Seems to be involved in the abscisic acid (ABA) signaling pathway (PubMed:11340187). Could also be able to hydrolyze PtdIns(4,5)P2 and PtdIns(3,4,5)P3 (PubMed:23658066).2 Publications
Catalytic activityi
- 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate1 PublicationEC:3.1.3.561 Publication
- 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate1 PublicationEC:3.1.3.561 Publication
GO - Molecular functioni
- inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Source: UniProtKB-EC
- inositol-1,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB-EC
- inositol-polyphosphate 5-phosphatase activity Source: TAIR
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB
- phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Source: UniProtKB
GO - Biological processi
- abscisic acid-activated signaling pathway Source: UniProtKB-KW
- inositol phosphate dephosphorylation Source: TAIR
- inositol trisphosphate metabolic process Source: UniProtKB
- phosphatidylinositol dephosphorylation Source: UniProtKB
- response to abscisic acid Source: TAIR
- seed germination Source: TAIR
- seedling development Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Biological process | Abscisic acid signaling pathway |
Enzyme and pathway databases
BioCyci | ARA:AT4G18010-MONOMER |
BRENDAi | 3.1.3.56, 399 |
Names & Taxonomyi
Protein namesi | Recommended name: Type I inositol polyphosphate 5-phosphatase 21 Publication (EC:3.1.3.561 Publication)Short name: At5PTase21 Publication |
Gene namesi | Name:IP5P21 Publication Synonyms:5P21 Publication Ordered Locus Names:At4g18010Imported ORF Names:T6K21.190Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT4G18010 |
TAIRi | locus:2141095, AT4G18010 |
Pathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209723 | 1 – 646 | Type I inositol polyphosphate 5-phosphatase 2Add BLAST | 646 |
Proteomic databases
PaxDbi | Q9FUR2 |
PRIDEi | Q9FUR2 |
ProteomicsDBi | 232225 [Q9FUR2-1] |
PTM databases
iPTMneti | Q9FUR2 |
Expressioni
Tissue specificityi
Expressed ubiquitously.1 Publication
Gene expression databases
ExpressionAtlasi | Q9FUR2, baseline and differential |
Genevisiblei | Q9FUR2, AT |
Interactioni
Binary interactionsi
Q9FUR2
With | #Exp. | IntAct |
---|---|---|
OBAP1A [Q9ZVY7] | 4 | EBI-25510894,EBI-4425342 |
Protein-protein interaction databases
BioGRIDi | 12819, 2 interactors |
IntActi | Q9FUR2, 1 interactor |
STRINGi | 3702.AT4G18010.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 495 – 510 | Catalytic 1By similarityAdd BLAST | 16 | |
Regioni | 575 – 590 | Catalytic 2By similarityAdd BLAST | 16 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 333 – 337 | Poly-Ser | 5 |
Sequence similaritiesi
Belongs to the inositol polyphosphate 5-phosphatase family.Curated
Phylogenomic databases
eggNOGi | KOG0565, Eukaryota |
InParanoidi | Q9FUR2 |
OrthoDBi | 1399831at2759 |
PhylomeDBi | Q9FUR2 |
Family and domain databases
Gene3Di | 3.60.10.10, 2 hits |
InterProi | View protein in InterPro IPR036691, Endo/exonu/phosph_ase_sf IPR000300, IPPc |
SMARTi | View protein in SMART SM00128, IPPc, 1 hit |
SUPFAMi | SSF56219, SSF56219, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9FUR2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKTRRGKRPE RFWPSIVMNK WLNRKPKVYD FSEDEIDTEP ESEDDVCSVK
60 70 80 90 100
DVPNVHCVTD EDSHNGRRGS EADHGNNISD GGVSVRGGYQ RKHRRGKSET
110 120 130 140 150
LRAQYINTKD IKVTVATWNV AGKRPSDDLE IEDWLSTDNP SDIYIIGFQE
160 170 180 190 200
VVPLNAGNVF GAEDRGPIPK WESIIRRTLN KSNKESVYDQ SPSCNNNALH
210 220 230 240 250
RSHSAPSSPI LAQEANSIIS HVMVENLVAD HSLDLATNEF IDAATALPSL
260 270 280 290 300
EPQRNPNMDW PELALDSNPQ IVGSEGKLRR VFSSNATLGF KLPENPSGAS
310 320 330 340 350
RFASEARQLK RSRSFETLNL SWNDIKEEID NRSSSSSEAE EAAKIMHDDS
360 370 380 390 400
SDGDSSSQDE EDGDKIRNSY GLPEDLVEEC RKVKDSQKYV RIVSKQMVGI
410 420 430 440 450
YVSVWIRRRL RRHVNNLKVS PVGVGLMGYM GNKGSVSISM TLYQSRMCFV
460 470 480 490 500
CSHLTSGHKD GAEQRRNADV YEIIRRTRFA SVLDTDQPRT IPCHDQVFWF
510 520 530 540 550
GDLNYRLNMS DGEVRKLVSQ KRWDELKNSD QLIRELRRGH VFDGWREGPI
560 570 580 590 600
KFPPTYKYEF DSDRYAGENL REPEKKRAPA WCDRILWLGK GIRQECYKRS
610 620 630 640
EIRMSDHRPV TSIFNVGVEV FDHRKLQRAL HVNNAAASAV HPEPSF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2H1ZEM5 | A0A2H1ZEM5_ARATH | Myo-inositol polyphosphate 5-phosph... | IP5PII 4, 5)P3 5-PHOSPHATASE II, 5PTASE2, AT5PTASE2, INOSITOL(1 | 581 | Annotation score: |
Sequence cautioni
The sequence CAA17144 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB78803 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 72 | A → R in CAB59428 (Ref. 2) Curated | 1 | |
Sequence conflicti | 483 | L → F in AAD10829 (Ref. 3) Curated | 1 | |
Sequence conflicti | 573 | P → G in AAG17825 (PubMed:11340187).Curated | 1 | |
Sequence conflicti | 573 | P → G in CAB59428 (Ref. 2) Curated | 1 | |
Sequence conflicti | 573 | P → G in AAD10829 (Ref. 3) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013849 | 327 – 359 | Missing in isoform 2. 1 PublicationAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF289634 mRNA Translation: AAG17825.1 AJ002295 mRNA Translation: CAB59428.1 AF117063 mRNA Translation: AAD10829.1 AL021889 Genomic DNA Translation: CAA17144.1 Sequence problems. AL161547 Genomic DNA Translation: CAB78803.1 Sequence problems. CP002687 Genomic DNA Translation: AEE83979.1 |
PIRi | T05087 T51937 T51938 |
RefSeqi | NP_567547.1, NM_117911.4 [Q9FUR2-1] |
Genome annotation databases
EnsemblPlantsi | AT4G18010.1; AT4G18010.1; AT4G18010 [Q9FUR2-1] |
GeneIDi | 827526 |
Gramenei | AT4G18010.1; AT4G18010.1; AT4G18010 [Q9FUR2-1] |
KEGGi | ath:AT4G18010 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF289634 mRNA Translation: AAG17825.1 AJ002295 mRNA Translation: CAB59428.1 AF117063 mRNA Translation: AAD10829.1 AL021889 Genomic DNA Translation: CAA17144.1 Sequence problems. AL161547 Genomic DNA Translation: CAB78803.1 Sequence problems. CP002687 Genomic DNA Translation: AEE83979.1 |
PIRi | T05087 T51937 T51938 |
RefSeqi | NP_567547.1, NM_117911.4 [Q9FUR2-1] |
3D structure databases
SMRi | Q9FUR2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 12819, 2 interactors |
IntActi | Q9FUR2, 1 interactor |
STRINGi | 3702.AT4G18010.1 |
PTM databases
iPTMneti | Q9FUR2 |
Proteomic databases
PaxDbi | Q9FUR2 |
PRIDEi | Q9FUR2 |
ProteomicsDBi | 232225 [Q9FUR2-1] |
Genome annotation databases
EnsemblPlantsi | AT4G18010.1; AT4G18010.1; AT4G18010 [Q9FUR2-1] |
GeneIDi | 827526 |
Gramenei | AT4G18010.1; AT4G18010.1; AT4G18010 [Q9FUR2-1] |
KEGGi | ath:AT4G18010 |
Organism-specific databases
Araporti | AT4G18010 |
TAIRi | locus:2141095, AT4G18010 |
Phylogenomic databases
eggNOGi | KOG0565, Eukaryota |
InParanoidi | Q9FUR2 |
OrthoDBi | 1399831at2759 |
PhylomeDBi | Q9FUR2 |
Enzyme and pathway databases
BioCyci | ARA:AT4G18010-MONOMER |
BRENDAi | 3.1.3.56, 399 |
Miscellaneous databases
PROi | PR:Q9FUR2 |
Gene expression databases
ExpressionAtlasi | Q9FUR2, baseline and differential |
Genevisiblei | Q9FUR2, AT |
Family and domain databases
Gene3Di | 3.60.10.10, 2 hits |
InterProi | View protein in InterPro IPR036691, Endo/exonu/phosph_ase_sf IPR000300, IPPc |
SMARTi | View protein in SMART SM00128, IPPc, 1 hit |
SUPFAMi | SSF56219, SSF56219, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IP5P2_ARATH | |
Accessioni | Q9FUR2Primary (citable) accession number: Q9FUR2 Secondary accession number(s): O49700, Q9SNF1, Q9ZSC3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | June 7, 2005 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families