UniProtKB - Q9FSB7 (CHS3_RUTGR)
Protein
Chalcone synthase 3
Gene
CHS3
Organism
Ruta graveolens (Common rue)
Status
Functioni
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
Catalytic activityi
- 4-coumaroyl-CoA + 2 H+ + 3 malonyl-CoA = 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoAPROSITE-ProRule annotationEC:2.3.1.74PROSITE-ProRule annotation
: flavonoid biosynthesis Pathwayi
This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 166 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- naringenin-chalcone synthase activity Source: UniProtKB-EC
GO - Biological processi
- flavonoid biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Flavonoid biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00154 |
Names & Taxonomyi
Protein namesi | Recommended name: Chalcone synthase 3 (EC:2.3.1.74)Alternative name(s): Naringenin-chalcone synthase 3 |
Gene namesi | Name:CHS3 |
Organismi | Ruta graveolens (Common rue) |
Taxonomic identifieri | 37565 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Sapindales › Rutaceae › Rutoideae › Ruta |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000216047 | 1 – 393 | Chalcone synthase 3Add BLAST | 393 |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR012328, Chalcone/stilbene_synt_C IPR001099, Chalcone/stilbene_synt_N IPR018088, Chalcone/stilbene_synthase_AS IPR011141, Polyketide_synthase_type-III IPR016039, Thiolase-like |
PANTHERi | PTHR11877, PTHR11877, 1 hit |
Pfami | View protein in Pfam PF02797, Chal_sti_synt_C, 1 hit PF00195, Chal_sti_synt_N, 1 hit |
PIRSFi | PIRSF000451, PKS_III, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
PROSITEi | View protein in PROSITE PS00441, CHALCONE_SYNTH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9FSB7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAVTVEEIR KAQRADGPAT VLAIGTATPA NYVTQADYPD YYFRITKSEH
60 70 80 90 100
MTDLKEKFKR MCDKSMIRKR YMHLTEEILK ENPNMCAYMA PSLDARQDIV
110 120 130 140 150
VVEVPKLGKE AAAKAIKEWG QPKSKITHLI FCTTSGVDMP GCDYQLTKLL
160 170 180 190 200
GLRPSVKRFM MYQQGCFAGG TVLRLAKDLA ENNRGARVLV VCSEITAVTF
210 220 230 240 250
RGPVDTHLDS LVGQALFGDG AAAVIVGADP DESIERPLYQ LVSAAQTILP
260 270 280 290 300
DSDGAIDGHL REVGLTFHLL KDVPGLISKN IEKSLKEAFG PIGISDWNSI
310 320 330 340 350
FWIAHPGGPA ILDQVEEKLE LKEEKLRATR HVLSEYGNMS SACVLFILDE
360 370 380 390
MRKKCAEEGM ATTGEGLEWG VLFGFGPGLT VETVVLRSVP IKA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ297791 mRNA Translation: CAC14061.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ297791 mRNA Translation: CAC14061.2 |
3D structure databases
SMRi | Q9FSB7 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00154 |
Family and domain databases
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR012328, Chalcone/stilbene_synt_C IPR001099, Chalcone/stilbene_synt_N IPR018088, Chalcone/stilbene_synthase_AS IPR011141, Polyketide_synthase_type-III IPR016039, Thiolase-like |
PANTHERi | PTHR11877, PTHR11877, 1 hit |
Pfami | View protein in Pfam PF02797, Chal_sti_synt_C, 1 hit PF00195, Chal_sti_synt_N, 1 hit |
PIRSFi | PIRSF000451, PKS_III, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
PROSITEi | View protein in PROSITE PS00441, CHALCONE_SYNTH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CHS3_RUTGR | |
Accessioni | Q9FSB7Primary (citable) accession number: Q9FSB7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 25, 2003 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families