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Entry version 143 (18 Sep 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Serine/threonine-protein kinase TOR

Gene

TOR

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential cell growth regulator that controls development from early embryo to seed production. Controls plant growth in environmental stress conditions. Acts through the phosphorylation of downstream effectors that are recruited by the binding partner RAPTOR. Acts by activating transcription, protein synthesis and ribosome biogenesis, and inhibiting mRNA degradation and autophagy. Can phosphorylate TAP46, a regulatory subunit of protein phosphatase 2A that modulates cell growth and survival (PubMed:21216945). Involved in modulating the transition from heterotrophic to photoautotrophic growth by regulating the expression of chloroplast- and photosynthesis-associated genes (PubMed:27479935). Essential for auxin signaling transduction, probably acting in polysomes to maintain the active ATPK1/S6K1 (and thus TIF3H1/eIF3h) phosphorylation status that is critical for translation reinitiation (e.g. uORF-mRNAs loading) (PubMed:23524850, PubMed:27014314). Promotes abscisic acid (ABA) biosynthesis (PubMed:26459592). Involved in the regulation of sugar-mediated (e.g. glucose and sucrose) glycolysis- and mitochondrial bioenergetics-dependent root growth promotion (PubMed:23542588). Required for sugar (e.g. glucose) promotion of hypocotyl elongation in the dark, by activating the brassinosteroid pathway and stabilizing BZR1. The regulation of BZR1 degradation is dependent on autophagy (PubMed:27345161). Regulates the expression, phosphorylation and ribosome association of MRFs (e.g. MRF1, MRF3 and MRF4), especially under energy-deficient conditions (PubMed:29084871).17 Publications
(Microbial infection) Binding to cauliflower mosaic virus (CaMV) Tav protein is critical for both translation reinitiation and viral fitness (PubMed:21343906). When activated by CaMV P6, promotes CaMV translation by inhibiting cellular autophagy and suppressing both silencing and innate immunity, thus confering sensitivity to P.syringae (PubMed:27120694).2 Publications
(Microbial infection) Required during infection by some potyvirus such as Watermelon mosaic virus (WMV) but not for turnip mosaic virus (TuMV).1 Publication

Miscellaneous

Inducible silencing in seedlings or adult plants leads to plant growth arrest. Plants slightly silencing TOR show constitutive autophagy and reduced shoot and root growth, leaf size, seed production and resistance to osmotic stress. Plants overexpressing TOR show increased shoot and root growth, leaf size, seed production and resistance to osmotic stress. Plants expressing FKBP12 (BP12) are sensitive to rapamycin. BP12 plants repressed by rapamycin exhibit slower growth and development leading to poor nutrient uptake and light energy utilization.6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Almost insensitive to rapamycin (PubMed:23963679). Strongly repressed by specific active site inhibitors (asTORis) such as AZD-8055, TORIN2 and WYE-132, and, to a lesser extent, by KU63794, WYE-354 and TORIN1, leading to impaired photoautotrophic growth and abnormally early meristematic cells differentiation (PubMed:23963679, PubMed:23524850). Repression by TORIN1 leads to impaired responses to auxin, including gravitropism (PubMed:23524850). Combined treatment with rapamycin and active-site inhibitors (e.g. Torin1 and AZD-8055) results in synergistic inhibition of activity and plant growth (PubMed:27479935). Inhibition by KU63794 leads to reduced auxin content in root tips (PubMed:27014314). AZD-8055 treatment reduces abscisic acid (ABA) levels (PubMed:26459592). In addition, inhibition by AZD-8055 leads to a strong reduction of watermelon mosaic virus (WMV) infection (PubMed:25979731).6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processAbscisic acid biosynthesis, Auxin signaling pathway, Brassinosteroid signaling pathway, Growth regulation, Host-virus interaction, Plant defense
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase TORBy similarity (EC:2.7.11.1By similarity)
Alternative name(s):
Protein TARGET OF RAPAMYCIN1 Publication
Short name:
AtTOR1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOR1 Publication
Ordered Locus Names:At1g50030Imported
ORF Names:F2J10.19Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT1G50030

The Arabidopsis Information Resource

More...
TAIRi
locus:2031090 AT1G50030

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryo lethality when homozygous. Premature arrest of endosperm and embryo development. RNAi mutant exhibits plant growth arrest and reduced expression of brassinosteroid (BR)-responsive genes, as well as abolished exogenous sugar-mediated promotion of BZR1 accumulation (PubMed:27345161). RNAi plants are impaired in sugar-mediated (e.g. glucose and sucrose) root growth promotion and associated genes expression (PubMed:23542588). In response to auxin, deficient plants have polysomes prebound by inactive ATPK1/S6K1, and loading of uORF-mRNAs and activation TIF3H1/eIF3h are impaired (PubMed:23524850). In RNAi plants, severe alteration of watermelon mosaic virus (WMV) infection, but only slight delay of turnip mosaic virus (TuMV) infection (PubMed:25979731). Deficient plants are resistant to viral infection by cauliflower mosaic virus (CaMV), by failing to support CaMV Tav protein-mediated transactivation of reinitiation (PubMed:21343906).6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2077 – 2080Missing : Loss of nuclear localization. 1 Publication4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004093301 – 2481Serine/threonine-protein kinase TORAdd BLAST2481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2424Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Activated by phosphorylation on Ser-2424 triggered by cauliflower mosaic virus P6 and auxin.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9FR53

PRoteomics IDEntifications database

More...
PRIDEi
Q9FR53

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9FR53

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in root meristems, shoot apical meristem (SAM) and floral buds.4 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

One day after fertilization, expressed in endosperm, embryo, and the chalazal proliferating tissue. At globular stage, no longer expressed in endosperm, but still in embryo up to the heart and torpedo stages. In mature embryo, expressed in the apical and primary root meristems and dividing vascular tissues. During lateral root formation, expressed in the lateral root primordia and remains during the formation of the emerging secondary root meristem.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Activation by auxin triggers recruitment to polysomes which release inactive ATPK1/S6K1.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9FR53 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9FR53 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAPTOR1 and itself.

Interacts with FKBP12 in a rapamycin-dependent manner. Binds to LST8-1 (PubMed:22307851). Hyperactivated upon interaction with cauliflower mosaic virus (CaMV) Tav protein (PubMed:21343906).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
26652, 2 interactors

Database of interacting proteins

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DIPi
DIP-39421N

Protein interaction database and analysis system

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IntActi
Q9FR53, 10 interactors

Molecular INTeraction database

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MINTi
Q9FR53

STRING: functional protein association networks

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STRINGi
3702.AT1G50030.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9FR53

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati205 – 242HEAT 1Sequence analysisAdd BLAST38
Repeati292 – 329HEAT 2Sequence analysisAdd BLAST38
Repeati373 – 410HEAT 3Sequence analysisAdd BLAST38
Repeati434 – 471HEAT 4Sequence analysisAdd BLAST38
Repeati569 – 607HEAT 5Sequence analysisAdd BLAST39
Repeati608 – 645HEAT 6Sequence analysisAdd BLAST38
Repeati737 – 775HEAT 7Sequence analysisAdd BLAST39
Repeati781 – 819HEAT 8Sequence analysisAdd BLAST39
Repeati866 – 904HEAT 9Sequence analysisAdd BLAST39
Repeati908 – 945HEAT 10Sequence analysisAdd BLAST38
Repeati952 – 992HEAT 11Sequence analysisAdd BLAST41
Repeati996 – 1036HEAT 12Sequence analysisAdd BLAST41
Repeati1037 – 1075HEAT 13Sequence analysisAdd BLAST39
Repeati1077 – 1114HEAT 14Sequence analysisAdd BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1309 – 1887FATPROSITE-ProRule annotationAdd BLAST579
Domaini2091 – 2481PI3K/PI4KPROSITE-ProRule annotationAdd BLAST391
Domaini2449 – 2481FATCPROSITE-ProRule annotationAdd BLAST33

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1505 – 1512Nuclear localization signalPROSITE-ProRule annotation8
Motifi2075 – 2080Nuclear localization signalCurated6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The kinase domain is required for its function.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0891 Eukaryota
COG5032 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000163215

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9FR53

KEGG Orthology (KO)

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KOi
K07203

Identification of Orthologs from Complete Genome Data

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OMAi
LNIQRYP

Database of Orthologous Groups

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OrthoDBi
26975at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9FR53

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1070.11, 1 hit
1.20.120.150, 1 hit
1.25.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024585 DUF3385_TOR
IPR003152 FATC_dom
IPR009076 FRB_dom
IPR036738 FRB_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR026683 TOR

The PANTHER Classification System

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PANTHERi
PTHR11139:SF9 PTHR11139:SF9, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF11865 DUF3385, 1 hit
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF08771 FRB_dom, 1 hit
PF00454 PI3_PI4_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01346 DUF3385, 1 hit
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47212 SSF47212, 1 hit
SSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 1 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. According to EST sequences.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9FR53-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTSSQSFVA GRPASMASPS QSHRFCGPSA TASGGGSFDT LNRVIADLCS
60 70 80 90 100
RGNPKEGAPL AFRKHVEEAV RDLSGEASSR FMEQLYDRIA NLIESTDVAE
110 120 130 140 150
NMGALRAIDE LTEIGFGENA TKVSRFAGYM RTVFELKRDP EILVLASRVL
160 170 180 190 200
GHLARAGGAM TSDEVEFQMK TAFDWLRVDR VEYRRFAAVL ILKEMAENAS
210 220 230 240 250
TVFNVHVPEF VDAIWVALRD PQLQVRERAV EALRACLRVI EKRETRWRVQ
260 270 280 290 300
WYYRMFEATQ DGLGRNAPVH SIHGSLLAVG ELLRNTGEFM MSRYREVAEI
310 320 330 340 350
VLRYLEHRDR LVRLSITSLL PRIAHFLRDR FVTNYLTICM NHILTVLRIP
360 370 380 390 400
AERASGFIAL GEMAGALDGE LIHYLPTIMS HLRDAIAPRK GRPLLEAVAC
410 420 430 440 450
VGNIAKAMGS TVETHVRDLL DVMFSSSLSS TLVDALDQIT ISIPSLLPTV
460 470 480 490 500
QDRLLDCISL VLSKSHYSQA KPPVTIVRGS TVGMAPQSSD PSCSAQVQLA
510 520 530 540 550
LQTLARFNFK GHDLLEFARE SVVVYLDDED AATRKDAALC CCRLIANSLS
560 570 580 590 600
GITQFGSSRS TRAGGRRRRL VEEIVEKLLR TAVADADVTV RKSIFVALFG
610 620 630 640 650
NQCFDDYLAQ ADSLTAIFAS LNDEDLDVRE YAISVAGRLS EKNPAYVLPA
660 670 680 690 700
LRRHLIQLLT YLELSADNKC REESAKLLGC LVRNCERLIL PYVAPVQKAL
710 720 730 740 750
VARLSEGTGV NANNNIVTGV LVTVGDLARV GGLAMRQYIP ELMPLIVEAL
760 770 780 790 800
MDGAAVAKRE VAVSTLGQVV QSTGYVVTPY KEYPLLLGLL LKLLKGDLVW
810 820 830 840 850
STRREVLKVL GIMGALDPHV HKRNQQSLSG SHGEVPRGTG DSGQPIPSID
860 870 880 890 900
ELPVELRPSF ATSEDYYSTV AINSLMRILR DASLLSYHKR VVRSLMIIFK
910 920 930 940 950
SMGLGCVPYL PKVLPELFHT VRTSDENLKD FITWGLGTLV SIVRQHIRKY
960 970 980 990 1000
LPELLSLVSE LWSSFTLPGP IRPSRGLPVL HLLEHLCLAL NDEFRTYLPV
1010 1020 1030 1040 1050
ILPCFIQVLG DAERFNDYTY VPDILHTLEV FGGTLDEHMH LLLPALIRLF
1060 1070 1080 1090 1100
KVDAPVAIRR DAIKTLTRVI PCVQVTGHIS ALVHHLKLVL DGKNDELRKD
1110 1120 1130 1140 1150
AVDALCCLAH ALGEDFTIFI ESIHKLLLKH RLRHKEFEEI HARWRRREPL
1160 1170 1180 1190 1200
IVATTATQQL SRRLPVEVIR DPVIENEIDP FEEGTDRNHQ VNDGRLRTAG
1210 1220 1230 1240 1250
EASQRSTKED WEEWMRHFSI ELLKESPSPA LRTCAKLAQL QPFVGRELFA
1260 1270 1280 1290 1300
AGFVSCWAQL NESSQKQLVR SLEMAFSSPN IPPEILATLL NLAEFMEHDE
1310 1320 1330 1340 1350
KPLPIDIRLL GALAEKCRVF AKALHYKEME FEGPRSKRMD ANPVAVVEAL
1360 1370 1380 1390 1400
IHINNQLHQH EAAVGILTYA QQHLDVQLKE SWYEKLQRWD DALKAYTLKA
1410 1420 1430 1440 1450
SQTTNPHLVL EATLGQMRCL AALARWEELN NLCKEYWSPA EPSARLEMAP
1460 1470 1480 1490 1500
MAAQAAWNMG EWDQMAEYVS RLDDGDETKL RGLASPVSSG DGSSNGTFFR
1510 1520 1530 1540 1550
AVLLVRRAKY DEAREYVERA RKCLATELAA LVLESYERAY SNMVRVQQLS
1560 1570 1580 1590 1600
ELEEVIEYYT LPVGNTIAEE RRALIRNMWT QRIQGSKRNV EVWQALLAVR
1610 1620 1630 1640 1650
ALVLPPTEDV ETWLKFASLC RKSGRISQAK STLLKLLPFD PEVSPENMQY
1660 1670 1680 1690 1700
HGPPQVMLGY LKYQWSLGEE RKRKEAFTKL QILTRELSSV PHSQSDILAS
1710 1720 1730 1740 1750
MVSSKGANVP LLARVNLKLG TWQWALSSGL NDGSIQEIRD AFDKSTCYAP
1760 1770 1780 1790 1800
KWAKAWHTWA LFNTAVMSHY ISRGQIASQY VVSAVTGYFY SIACAANAKG
1810 1820 1830 1840 1850
VDDSLQDILR LLTLWFNHGA TADVQTALKT GFSHVNINTW LVVLPQIIAR
1860 1870 1880 1890 1900
IHSNNRAVRE LIQSLLIRIG ENHPQALMYP LLVACKSISN LRRAAAQEVV
1910 1920 1930 1940 1950
DKVRQHSGAL VDQAQLVSHE LIRVAILWHE MWHEALEEAS RLYFGEHNIE
1960 1970 1980 1990 2000
GMLKVLEPLH DMLDEGVKKD STTIQERAFI EAYRHELKEA HECCCNYKIT
2010 2020 2030 2040 2050
GKDAELTQAW DLYYHVFKRI DKQLASLTTL DLESVSPELL LCRDLELAVP
2060 2070 2080 2090 2100
GTYRADAPVV TISSFSRQLV VITSKQRPRK LTIHGNDGED YAFLLKGHED
2110 2120 2130 2140 2150
LRQDERVMQL FGLVNTLLEN SRKTAEKDLS IQRYSVIPLS PNSGLIGWVP
2160 2170 2180 2190 2200
NCDTLHHLIR EHRDARKIIL NQENKHMLSF APDYDNLPLI AKVEVFEYAL
2210 2220 2230 2240 2250
ENTEGNDLSR VLWLKSRSSE VWLERRTNYT RSLAVMSMVG YILGLGDRHP
2260 2270 2280 2290 2300
SNLMLHRYSG KILHIDFGDC FEASMNREKF PEKVPFRLTR MLVKAMEVSG
2310 2320 2330 2340 2350
IEGNFRSTCE NVMQVLRTNK DSVMAMMEAF VHDPLINWRL FNFNEVPQLA
2360 2370 2380 2390 2400
LLGNNNPNAP ADVEPDEEDE DPADIDLPQP QRSTREKEIL QAVNMLGDAN
2410 2420 2430 2440 2450
EVLNERAVVV MARMSHKLTG RDFSSSAIPS NPIADHNNLL GGDSHEVEHG
2460 2470 2480
LSVKVQVQKL INQATSHENL CQNYVGWCPF W
Length:2,481
Mass (Da):279,190
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA663EA9A9366F93
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F4I4X6F4I4X6_ARATH
Serine/threonine-protein kinase TOR
TOR target of rapamycin, At1g50030, F2J10.19, F2J10_19
2,454Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF76442 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF178967 mRNA Translation: AAG43423.1
AC015445 Genomic DNA Translation: AAF76442.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE32509.1

Protein sequence database of the Protein Information Resource

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PIRi
G96536

NCBI Reference Sequences

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RefSeqi
NP_175425.2, NM_103891.4 [Q9FR53-1]

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT1G50030.1; AT1G50030.1; AT1G50030 [Q9FR53-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
841427

Gramene; a comparative resource for plants

More...
Gramenei
AT1G50030.1; AT1G50030.1; AT1G50030 [Q9FR53-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT1G50030

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178967 mRNA Translation: AAG43423.1
AC015445 Genomic DNA Translation: AAF76442.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE32509.1
PIRiG96536
RefSeqiNP_175425.2, NM_103891.4 [Q9FR53-1]

3D structure databases

SMRiQ9FR53
ModBaseiSearch...

Protein-protein interaction databases

BioGridi26652, 2 interactors
DIPiDIP-39421N
IntActiQ9FR53, 10 interactors
MINTiQ9FR53
STRINGi3702.AT1G50030.1

PTM databases

iPTMnetiQ9FR53

Proteomic databases

PaxDbiQ9FR53
PRIDEiQ9FR53

Genome annotation databases

EnsemblPlantsiAT1G50030.1; AT1G50030.1; AT1G50030 [Q9FR53-1]
GeneIDi841427
GrameneiAT1G50030.1; AT1G50030.1; AT1G50030 [Q9FR53-1]
KEGGiath:AT1G50030

Organism-specific databases

AraportiAT1G50030
TAIRilocus:2031090 AT1G50030

Phylogenomic databases

eggNOGiKOG0891 Eukaryota
COG5032 LUCA
HOGENOMiHOG000163215
InParanoidiQ9FR53
KOiK07203
OMAiLNIQRYP
OrthoDBi26975at2759
PhylomeDBiQ9FR53

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9FR53

Gene expression databases

ExpressionAtlasiQ9FR53 baseline and differential
GenevisibleiQ9FR53 AT

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.20.120.150, 1 hit
1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024585 DUF3385_TOR
IPR003152 FATC_dom
IPR009076 FRB_dom
IPR036738 FRB_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR026683 TOR
PANTHERiPTHR11139:SF9 PTHR11139:SF9, 1 hit
PfamiView protein in Pfam
PF11865 DUF3385, 1 hit
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF08771 FRB_dom, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM01346 DUF3385, 1 hit
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF47212 SSF47212, 1 hit
SSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOR_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FR53
Secondary accession number(s): Q9LPM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: March 1, 2001
Last modified: September 18, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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