UniProtKB - Q9FR35 (PRX2C_ORYSJ)
Protein
Peroxiredoxin-2C
Gene
PRXIIC
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin or glutaredoxin system. May be involved in intracellular redox signaling.
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.By similarity
Miscellaneous
The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.By similarity
Catalytic activityi
- EC:1.11.1.25By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 51 | Cysteine sulfenic acid (-SOH) intermediateBy similarity | 1 |
GO - Molecular functioni
- thioredoxin peroxidase activity Source: GO_Central
GO - Biological processi
- cell redox homeostasis Source: GO_Central
- cellular response to oxidative stress Source: GO_Central
- hydrogen peroxide catabolic process Source: GO_Central
Keywordsi
Molecular function | Antioxidant, Oxidoreductase, Peroxidase |
Protein family/group databases
PeroxiBasei | 4017, OsPrxII03 |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxiredoxin-2C (EC:1.11.1.25By similarity)Alternative name(s): Glutaredoxin-dependent peroxiredoxinCurated Peroxiredoxin IIC Thioredoxin peroxidase 2C |
Gene namesi | Name:PRXIIC Ordered Locus Names:Os01g0675100, LOC_Os01g48420 ORF Names:OJ1117_G01.9, OsJ_002891, P0485G01.43 |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000282282 | 2 – 162 | Peroxiredoxin-2CAdd BLAST | 161 |
Proteomic databases
PaxDbi | Q9FR35 |
PRIDEi | Q9FR35 |
Interactioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
STRINGi | 4530.OS01T0675100-01 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 162 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | 159 |
Sequence similaritiesi
Keywords - Domaini
Redox-active centerPhylogenomic databases
eggNOGi | KOG0541, Eukaryota |
HOGENOMi | CLU_072440_1_2_1 |
InParanoidi | Q9FR35 |
OMAi | GYINHPK |
OrthoDBi | 1281610at2759 |
Family and domain databases
CDDi | cd03013, PRX5_like, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR037944, PRX5-like IPR013740, Redoxin IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
PANTHERi | PTHR10430, PTHR10430, 1 hit |
Pfami | View protein in Pfam PF08534, Redoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9FR35-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPVAVGDTL PDGQLGWFDG EDKLQQVSVH GLAAGKKVVL FGVPGAFTPT
60 70 80 90 100
CSNQHVPGFI NQAEQLKAKG VDDILLVSVN DPFVMKAWAK SYPENKHVKF
110 120 130 140 150
LADGLGTYTK ALGLELDLSE KGLGIRSRRF ALLADNLKVT VANIEEGGQF
160
TISGAEEILK AL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF203879 mRNA Translation: AAG40130.1 AP003264 Genomic DNA Translation: BAC01192.1 AP003374 Genomic DNA Translation: BAB93323.1 AP008207 Genomic DNA Translation: BAF05759.1 AP014957 Genomic DNA Translation: BAS73651.1 CM000138 Genomic DNA Translation: EAZ13066.1 AK058509 mRNA Translation: BAG86716.1 |
RefSeqi | XP_015622003.1, XM_015766517.1 |
Genome annotation databases
EnsemblPlantsi | Os01t0675100-01; Os01t0675100-01; Os01g0675100 |
GeneIDi | 4325511 |
Gramenei | Os01t0675100-01; Os01t0675100-01; Os01g0675100 |
KEGGi | osa:4325511 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF203879 mRNA Translation: AAG40130.1 AP003264 Genomic DNA Translation: BAC01192.1 AP003374 Genomic DNA Translation: BAB93323.1 AP008207 Genomic DNA Translation: BAF05759.1 AP014957 Genomic DNA Translation: BAS73651.1 CM000138 Genomic DNA Translation: EAZ13066.1 AK058509 mRNA Translation: BAG86716.1 |
RefSeqi | XP_015622003.1, XM_015766517.1 |
3D structure databases
SMRi | Q9FR35 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4530.OS01T0675100-01 |
Protein family/group databases
PeroxiBasei | 4017, OsPrxII03 |
Proteomic databases
PaxDbi | Q9FR35 |
PRIDEi | Q9FR35 |
Genome annotation databases
EnsemblPlantsi | Os01t0675100-01; Os01t0675100-01; Os01g0675100 |
GeneIDi | 4325511 |
Gramenei | Os01t0675100-01; Os01t0675100-01; Os01g0675100 |
KEGGi | osa:4325511 |
Phylogenomic databases
eggNOGi | KOG0541, Eukaryota |
HOGENOMi | CLU_072440_1_2_1 |
InParanoidi | Q9FR35 |
OMAi | GYINHPK |
OrthoDBi | 1281610at2759 |
Gene expression databases
Genevisiblei | Q9FR35, OS |
Family and domain databases
CDDi | cd03013, PRX5_like, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR037944, PRX5-like IPR013740, Redoxin IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
PANTHERi | PTHR10430, PTHR10430, 1 hit |
Pfami | View protein in Pfam PF08534, Redoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRX2C_ORYSJ | |
Accessioni | Q9FR35Primary (citable) accession number: Q9FR35 Secondary accession number(s): B7E2W9, Q7F529 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations - SIMILARITY comments
Index of protein domains and families