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Protein

Ubiquitin carboxyl-terminal hydrolase 1

Gene

UBP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Is involved in resistance to the arginine analog canavanine (CAN).1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei211NucleophilePROSITE-ProRule annotation1
Active sitei1029Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri79 – 148UBP-typePROSITE-ProRule annotationAdd BLAST70

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-ATH-5696395 Formation of Incision Complex in GG-NER

Protein family/group databases

MEROPSiC19.091

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 1 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 1
Short name:
AtUBP1
Ubiquitin thioesterase 1
Ubiquitin-specific-processing protease 1
Gene namesi
Name:UBP1
Ordered Locus Names:At2g32780
ORF Names:F24L7.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G32780
TAIRilocus:2046392 AT2G32780

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi211C → S: Confers CAN sensitivity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806921 – 1083Ubiquitin carboxyl-terminal hydrolase 1Add BLAST1083

Proteomic databases

PaxDbiQ9FPT5

Expressioni

Gene expression databases

ExpressionAtlasiQ9FPT5 baseline and differential
GenevisibleiQ9FPT5 AT

Interactioni

Protein-protein interaction databases

BioGridi3186, 2 interactors
STRINGi3702.AT2G32780.1

Structurei

3D structure databases

ProteinModelPortaliQ9FPT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini202 – 1083USPAdd BLAST882

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri79 – 148UBP-typePROSITE-ProRule annotationAdd BLAST70

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1873 Eukaryota
COG5560 LUCA
HOGENOMiHOG000090316
InParanoidiQ9FPT5
KOiK11844
OMAiTETLMHD
OrthoDBiEOG093602LO
PhylomeDBiQ9FPT5

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF02148 zf-UBP, 1 hit
SMARTiView protein in SMART
SM00290 ZnF_UBP, 1 hit
SUPFAMiSSF54001 SSF54001, 3 hits
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
PS50271 ZF_UBP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FPT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFAATVSEK QSEQSVEVTE EFAVTMTEKR SCVHFDKYVD LDKLLKIIKS
60 70 80 90 100
YQQIKCGECN ERVHVKRGSR WGASNRRDWY SSSDQNCARN AIWLCLECGY
110 120 130 140 150
YVCGDVGLPT EAQSHVMGHN RLTRHRLVIQ CKNPQLRWCF SCQSLLPFDN
160 170 180 190 200
EENGEKKDLL LEVVKLIRER SPNTYSASFE TEFSCSGSIY GGIEARDGYA
210 220 230 240 250
VRGLVNLGNT CFFNSVMQNL LSLDQLREHF LKEDLSVSGP LVSSLKELFA
260 270 280 290 300
ESNSEASVFR NEINPRDLFF SVCSQAPQFR GYQQHDSHEL LRCLLDGLSI
310 320 330 340 350
EESSLRKKLG VSDSNDSSTY QKPTLIDSVF GGEISSTVSC LECGHFSKVY
360 370 380 390 400
EPFMDLSLPV PSMKLPPKKQ QILSQAKEVL KNGAVSKDSE VVSAKPASDH
410 420 430 440 450
NSTVPLFPSD HKIQSRPETS DNETDLVLLS DVSDTAPSTE AKGVNQILVG
460 470 480 490 500
STETLMHDND RTGKTVPDKE DVRATQSNEE TSASGISAVI DEAQVCGCPD
510 520 530 540 550
LEQSSSSANQ GADEELALMV ADSQVLYMPY KDHLFYDDYM VAEASSSFVS
560 570 580 590 600
GDHEPKKDYF DFSSFLDEPE IREGPVFRPL SKSEVYEAGF KADCSDDKTV
610 620 630 640 650
SAGKGEASSS FISSDHEQNI DYVDFSSFFD EPEISERPFF RPLSKSEVSE
660 670 680 690 700
AGFKADCSDD KTVSAGKGEA SSSFVSSDHE QNIDYVDFSS FFDEPEISER
710 720 730 740 750
PFFRPLSKSE VSEAGFMAVS GNDKTVRAGK GETFSSFMSG DNERNIDYVE
760 770 780 790 800
FTNRIFDDRG TSERPVFGPP SKAKVSEAGF VAVSSDSDPA VLDESDSPVS
810 820 830 840 850
VDRCLAQFTK HEILSEDNAW HCENCSKNLK LQRLREKRRT KEGLSNRWVN
860 870 880 890 900
ENGASSAFDE CRDSSLNQSC IDLENGYKAA PPITKLPNCK EEESAIDDGF
910 920 930 940 950
VGEENTKQAP ITSVTETPLL GGETISSQPA SDNECENWED LAVDSEEVIV
960 970 980 990 1000
KRDARKKVLI NKAPPVLTIH LKRFSQDARG RVSKLSGHVD FQEFIDLSKY
1010 1020 1030 1040 1050
MDTRCSEEDE PVYRLAGLVE HLGAMSRGHY VSYIRGGHKE RRDSDTKEPN
1060 1070 1080
SSIWYHASDS QVRPASLEEV LRSEAYILFY ERI
Length:1,083
Mass (Da):120,771
Last modified:April 26, 2005 - v2
Checksum:i55B881F9971199D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003974 Genomic DNA Translation: AAC04485.1
CP002685 Genomic DNA Translation: AEC08739.1
AF302658 mRNA Translation: AAG42749.1
PIRiT00790
RefSeqiNP_565753.1, NM_128838.2
UniGeneiAt.38022

Genome annotation databases

EnsemblPlantsiAT2G32780.1; AT2G32780.1; AT2G32780
GeneIDi817839
GrameneiAT2G32780.1; AT2G32780.1; AT2G32780
KEGGiath:AT2G32780

Similar proteinsi

Entry informationi

Entry nameiUBP1_ARATH
AccessioniPrimary (citable) accession number: Q9FPT5
Secondary accession number(s): O48839
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: June 20, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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