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UniProtKB - Q9FNJ8 (AROD5_ARATH)
Protein
Arogenate dehydratase 5, chloroplastic
Gene
ADT5
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine.
1 PublicationMiscellaneous
Has no detectable prehenate dehydratase activity.
Catalytic activityi
- EC:4.2.1.911 Publication
Kineticsi
- KM=1.72 mM for arogenate1 Publication
- Vmax=11.26 pmol/sec/µg enzyme with arogenate as substrate1 Publication
: L-phenylalanine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-phenylalanine from L-arogenate.1 Publication This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-phenylalanine from L-arogenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- arogenate dehydratase activity Source: TAIR
- prephenate dehydratase activity Source: InterPro
GO - Biological processi
- defense response Source: TAIR
- L-phenylalanine biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Lyase |
Biological process | Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesis |
Enzyme and pathway databases
BioCyci | ARA:AT5G22630-MONOMER |
BRENDAi | 4.2.1.91, 399 |
SABIO-RKi | Q9FNJ8 |
UniPathwayi | UPA00121;UER00344 |
Names & Taxonomyi
Protein namesi | Recommended name: Arogenate dehydratase 5, chloroplastic1 Publication (EC:4.2.1.911 Publication)Short name: AtADT51 Publication |
Gene namesi | Name:ADT51 Publication Ordered Locus Names:At5g22630Imported ORF Names:MDJ22.5Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G22630 |
TAIRi | locus:2162459, AT5G22630 |
Subcellular locationi
Chloroplast
- chloroplast stroma 1 Publication
Chloroplast
- chloroplast Source: TAIR
- chloroplast stroma Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Chloroplast, PlastidPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 38 | ChloroplastSequence analysisAdd BLAST | 38 | |
ChainiPRO_0000373794 | 39 – 425 | Arogenate dehydratase 5, chloroplasticAdd BLAST | 387 |
Proteomic databases
PaxDbi | Q9FNJ8 |
PRIDEi | Q9FNJ8 |
ProteomicsDBi | 246781 |
Expressioni
Tissue specificityi
Expressed in roots, leaves, stems, flowers and siliques. More abundant in stems and roots.1 Publication
Inductioni
Strongly up-regulated during stem elongation.1 Publication
Gene expression databases
ExpressionAtlasi | Q9FNJ8, baseline and differential |
Genevisiblei | Q9FNJ8, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 17601, 5 interactors |
IntActi | Q9FNJ8, 5 interactors |
STRINGi | 3702.AT5G22630.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 127 – 304 | Prephenate dehydratasePROSITE-ProRule annotationAdd BLAST | 178 | |
Domaini | 320 – 411 | ACTPROSITE-ProRule annotationAdd BLAST | 92 |
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2797, Eukaryota |
HOGENOMi | CLU_035008_4_1_1 |
InParanoidi | Q9FNJ8 |
OMAi | PMDMAPW |
OrthoDBi | 1090069at2759 |
PhylomeDBi | Q9FNJ8 |
Family and domain databases
InterProi | View protein in InterPro IPR045865, ACT-like_dom_sf IPR002912, ACT_dom IPR001086, Preph_deHydtase IPR018528, Preph_deHydtase_CS |
Pfami | View protein in Pfam PF00800, PDT, 1 hit |
SUPFAMi | SSF55021, SSF55021, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit PS00857, PREPHENATE_DEHYDR_1, 1 hit PS00858, PREPHENATE_DEHYDR_2, 1 hit PS51171, PREPHENATE_DEHYDR_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9FNJ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQTISPAFSC DLKSVIQPNL TAKKARYSHV NGKRVSVRCS YRSESFSFPN
60 70 80 90 100
GVGSSRADWQ SSCAILASKV VSAENSSSVA VVNGHSNGSV DLSLVPSKSQ
110 120 130 140 150
HNGKPGLIQP LTITDLSPAP SHGSTLRVAY QGVPGAYSEA AAGKAYPNSE
160 170 180 190 200
AIPCDQFDVA FQAVELWIAD RAVLPVENSL GGSIHRNYDL LLRHRLHIVG
210 220 230 240 250
EVQIPVHHCL LALPGVRTDC ITRVISHPQA LAQTEGSLNK LTPKAAIEAF
260 270 280 290 300
HDTAAAAEYI AANNLHDTAA VASARAAELY GLQILADGIQ DDAGNVTRFL
310 320 330 340 350
MLARDPIIPR TDRPFKTSIV FAAQEHKGTS VLFKVLSAFA FRNISLTKIE
360 370 380 390 400
SRPHQNCPVR VVGDENVGTS KHFEYTFYVD FEASMAEARA QNALAEVQEY
410 420
TSFLRVLGSY PMDMTPWSTL PSEDV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ411469 mRNA Translation: ABD67755.1 AB006699 Genomic DNA Translation: BAB11669.1 CP002688 Genomic DNA Translation: AED93055.1 AY058097 mRNA Translation: AAL24205.1 AY090235 mRNA Translation: AAL90899.1 AY149958 mRNA Translation: AAN31112.1 |
RefSeqi | NP_197655.1, NM_122169.3 |
Genome annotation databases
EnsemblPlantsi | AT5G22630.1; AT5G22630.1; AT5G22630 |
GeneIDi | 832326 |
Gramenei | AT5G22630.1; AT5G22630.1; AT5G22630 |
KEGGi | ath:AT5G22630 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ411469 mRNA Translation: ABD67755.1 AB006699 Genomic DNA Translation: BAB11669.1 CP002688 Genomic DNA Translation: AED93055.1 AY058097 mRNA Translation: AAL24205.1 AY090235 mRNA Translation: AAL90899.1 AY149958 mRNA Translation: AAN31112.1 |
RefSeqi | NP_197655.1, NM_122169.3 |
3D structure databases
AlphaFoldDBi | Q9FNJ8 |
SMRi | Q9FNJ8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 17601, 5 interactors |
IntActi | Q9FNJ8, 5 interactors |
STRINGi | 3702.AT5G22630.1 |
Proteomic databases
PaxDbi | Q9FNJ8 |
PRIDEi | Q9FNJ8 |
ProteomicsDBi | 246781 |
Genome annotation databases
EnsemblPlantsi | AT5G22630.1; AT5G22630.1; AT5G22630 |
GeneIDi | 832326 |
Gramenei | AT5G22630.1; AT5G22630.1; AT5G22630 |
KEGGi | ath:AT5G22630 |
Organism-specific databases
Araporti | AT5G22630 |
TAIRi | locus:2162459, AT5G22630 |
Phylogenomic databases
eggNOGi | KOG2797, Eukaryota |
HOGENOMi | CLU_035008_4_1_1 |
InParanoidi | Q9FNJ8 |
OMAi | PMDMAPW |
OrthoDBi | 1090069at2759 |
PhylomeDBi | Q9FNJ8 |
Enzyme and pathway databases
UniPathwayi | UPA00121;UER00344 |
BioCyci | ARA:AT5G22630-MONOMER |
BRENDAi | 4.2.1.91, 399 |
SABIO-RKi | Q9FNJ8 |
Miscellaneous databases
PROi | PR:Q9FNJ8 |
Gene expression databases
ExpressionAtlasi | Q9FNJ8, baseline and differential |
Genevisiblei | Q9FNJ8, AT |
Family and domain databases
InterProi | View protein in InterPro IPR045865, ACT-like_dom_sf IPR002912, ACT_dom IPR001086, Preph_deHydtase IPR018528, Preph_deHydtase_CS |
Pfami | View protein in Pfam PF00800, PDT, 1 hit |
SUPFAMi | SSF55021, SSF55021, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit PS00857, PREPHENATE_DEHYDR_1, 1 hit PS00858, PREPHENATE_DEHYDR_2, 1 hit PS51171, PREPHENATE_DEHYDR_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AROD5_ARATH | |
Accessioni | Q9FNJ8Primary (citable) accession number: Q9FNJ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | March 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways