Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9FNJ8 (AROD5_ARATH)

Entry version 94 (16 Jan 2019)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Arogenate dehydratase 5, chloroplastic

Gene

ADT5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine.1 Publication

Miscellaneous

Has no detectable prehenate dehydratase activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.72 mM for arogenate1 Publication
  1. Vmax=11.26 pmol/sec/µg enzyme with arogenate as substrate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-phenylalanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-phenylalanine from L-arogenate.
Proteins known to be involved in this subpathway in this organism are:
  1. Arogenate dehydratase (AXX17_At5g22060), Arogenate dehydratase (AXX17_At1g12160), Arogenate dehydratase (AXX17_At2g23810), Arogenate dehydratase (AXX17_At3g07630), Arogenate dehydratase (AXX17_At3g38410), Arogenate dehydratase (AXX17_At1g08050), Arogenate dehydratase 4, chloroplastic (ADT4), Arogenate dehydratase/prephenate dehydratase 1, chloroplastic (ADT1), Arogenate dehydratase/prephenate dehydratase 2, chloroplastic (ADT2), Arogenate dehydratase 5, chloroplastic (ADT5), Arogenate dehydratase 3, chloroplastic (ADT3), Arogenate dehydratase/prephenate dehydratase 6, chloroplastic (ADT6)
This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-phenylalanine from L-arogenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • arogenate dehydratase activity Source: TAIR
  • prephenate dehydratase activity Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • L-phenylalanine biosynthetic process Source: GO_Central
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		ARA:AT5G22630-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		4.2.1.91 399

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q9FNJ8

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi
UPA00121;UER00344

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arogenate dehydratase 5, chloroplastic (EC:4.2.1.91)
Short name:
AtADT5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADT5
Ordered Locus Names:At5g22630
ORF Names:MDJ22.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...Araporti		AT5G22630

The Arabidopsis Information Resource

More...TAIRi		locus:2162459 AT5G22630

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 38ChloroplastSequence analysisAdd BLAST38
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000037379439 – 425Arogenate dehydratase 5, chloroplasticAdd BLAST387

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9FNJ8

PRoteomics IDEntifications database

More...PRIDEi		Q9FNJ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in roots, leaves, stems, flowers and siliques. More abundant in stems and roots.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Strongly up-regulated during stem elongation.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9FNJ8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9FNJ8 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		17601, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q9FNJ8, 5 interactors

STRING: functional protein association networks

More...STRINGi		3702.AT5G22630.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9FNJ8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9FNJ8

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini127 – 304Prephenate dehydratasePROSITE-ProRule annotationAdd BLAST178
Domaini320 – 411ACTPROSITE-ProRule annotationAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 99Ser-richAdd BLAST64
Compositional biasi245 – 277Ala-richAdd BLAST33

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2797 Eukaryota
COG0077 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000018970

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9FNJ8

KEGG Orthology (KO)

More...KOi		K05359

Identification of Orthologs from Complete Genome Data

More...OMAi		MAPWSTS

Database of Orthologous Groups

More...OrthoDBi		1090069at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9FNJ8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002912 ACT_dom
IPR001086 Preph_deHydtase
IPR018528 Preph_deHydtase_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00800 PDT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51671 ACT, 1 hit
PS00857 PREPHENATE_DEHYDR_1, 1 hit
PS00858 PREPHENATE_DEHYDR_2, 1 hit
PS51171 PREPHENATE_DEHYDR_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FNJ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQTISPAFSC DLKSVIQPNL TAKKARYSHV NGKRVSVRCS YRSESFSFPN 
        60         70         80         90        100
GVGSSRADWQ SSCAILASKV VSAENSSSVA VVNGHSNGSV DLSLVPSKSQ 
       110        120        130        140        150
HNGKPGLIQP LTITDLSPAP SHGSTLRVAY QGVPGAYSEA AAGKAYPNSE 
       160        170        180        190        200
AIPCDQFDVA FQAVELWIAD RAVLPVENSL GGSIHRNYDL LLRHRLHIVG 
       210        220        230        240        250
EVQIPVHHCL LALPGVRTDC ITRVISHPQA LAQTEGSLNK LTPKAAIEAF 
       260        270        280        290        300
HDTAAAAEYI AANNLHDTAA VASARAAELY GLQILADGIQ DDAGNVTRFL 
       310        320        330        340        350
MLARDPIIPR TDRPFKTSIV FAAQEHKGTS VLFKVLSAFA FRNISLTKIE 
       360        370        380        390        400
SRPHQNCPVR VVGDENVGTS KHFEYTFYVD FEASMAEARA QNALAEVQEY 
       410        420 
TSFLRVLGSY PMDMTPWSTL PSEDV
Length:425
Mass (Da):45,928
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B6AD16F3DE48B3F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ411469 mRNA Translation: ABD67755.1
AB006699 Genomic DNA Translation: BAB11669.1
CP002688 Genomic DNA Translation: AED93055.1
AY058097 mRNA Translation: AAL24205.1
AY090235 mRNA Translation: AAL90899.1
AY149958 mRNA Translation: AAN31112.1

NCBI Reference Sequences

More...RefSeqi		NP_197655.1, NM_122169.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		At.20326
At.71496

Genome annotation databases

Ensembl plant genome annotation project

More...EnsemblPlantsi		AT5G22630.1; AT5G22630.1; AT5G22630

Database of genes from NCBI RefSeq genomes

More...GeneIDi		832326

Gramene; a comparative resource for plants

More...Gramenei		AT5G22630.1; AT5G22630.1; AT5G22630

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ath:AT5G22630

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ411469 mRNA Translation: ABD67755.1
AB006699 Genomic DNA Translation: BAB11669.1
CP002688 Genomic DNA Translation: AED93055.1
AY058097 mRNA Translation: AAL24205.1
AY090235 mRNA Translation: AAL90899.1
AY149958 mRNA Translation: AAN31112.1
RefSeqiNP_197655.1, NM_122169.3
UniGeneiAt.20326
At.71496

3D structure databases

ProteinModelPortaliQ9FNJ8
SMRiQ9FNJ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17601, 5 interactors
IntActiQ9FNJ8, 5 interactors
STRINGi3702.AT5G22630.1

Proteomic databases

PaxDbiQ9FNJ8
PRIDEiQ9FNJ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G22630.1; AT5G22630.1; AT5G22630
GeneIDi832326
GrameneiAT5G22630.1; AT5G22630.1; AT5G22630
KEGGiath:AT5G22630

Organism-specific databases

AraportiAT5G22630
TAIRilocus:2162459 AT5G22630

Phylogenomic databases

eggNOGiKOG2797 Eukaryota
COG0077 LUCA
HOGENOMiHOG000018970
InParanoidiQ9FNJ8
KOiK05359
OMAiMAPWSTS
OrthoDBi1090069at2759
PhylomeDBiQ9FNJ8

Enzyme and pathway databases

UniPathwayi
UPA00121;UER00344

BioCyciARA:AT5G22630-MONOMER
BRENDAi4.2.1.91 399
SABIO-RKiQ9FNJ8

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9FNJ8

Gene expression databases

ExpressionAtlasiQ9FNJ8 baseline and differential
GenevisibleiQ9FNJ8 AT

Family and domain databases

InterProiView protein in InterPro
IPR002912 ACT_dom
IPR001086 Preph_deHydtase
IPR018528 Preph_deHydtase_CS
PfamiView protein in Pfam
PF00800 PDT, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 1 hit
PS00857 PREPHENATE_DEHYDR_1, 1 hit
PS00858 PREPHENATE_DEHYDR_2, 1 hit
PS51171 PREPHENATE_DEHYDR_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAROD5_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FNJ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: March 1, 2001
Last modified: January 16, 2019
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again