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UniProtKB - Q9FNJ8 (AROD5_ARATH)

Entry version 106 (25 May 2022)
Sequence version 1 (01 Mar 2001)
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Protein

Arogenate dehydratase 5, chloroplastic

Gene

ADT5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine.

1 Publication

Miscellaneous

Has no detectable prehenate dehydratase activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.72 mM for arogenate1 Publication
  1. Vmax=11.26 pmol/sec/µg enzyme with arogenate as substrate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-phenylalanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-phenylalanine from L-arogenate.1 Publication This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-phenylalanine from L-arogenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		ARA:AT5G22630-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		4.2.1.91, 399

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q9FNJ8

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00121;UER00344

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arogenate dehydratase 5, chloroplastic1 Publication (EC:4.2.1.911 Publication)
Short name:
AtADT51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADT51 Publication
Ordered Locus Names:At5g22630Imported
ORF Names:MDJ22.5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...Araporti		AT5G22630

The Arabidopsis Information Resource

More...TAIRi		locus:2162459, AT5G22630

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chloroplast, Plastid

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 38ChloroplastSequence analysisAdd BLAST38
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000037379439 – 425Arogenate dehydratase 5, chloroplasticAdd BLAST387

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9FNJ8

PRoteomics IDEntifications database

More...PRIDEi		Q9FNJ8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		246781

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in roots, leaves, stems, flowers and siliques. More abundant in stems and roots.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Strongly up-regulated during stem elongation.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9FNJ8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9FNJ8, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		17601, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q9FNJ8, 5 interactors

STRING: functional protein association networks

More...STRINGi		3702.AT5G22630.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9FNJ8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9FNJ8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini127 – 304Prephenate dehydratasePROSITE-ProRule annotationAdd BLAST178
Domaini320 – 411ACTPROSITE-ProRule annotationAdd BLAST92

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2797, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_035008_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9FNJ8

Identification of Orthologs from Complete Genome Data

More...OMAi		PMDMAPW

Database of Orthologous Groups

More...OrthoDBi		1090069at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9FNJ8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR045865, ACT-like_dom_sf
IPR002912, ACT_dom
IPR001086, Preph_deHydtase
IPR018528, Preph_deHydtase_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00800, PDT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55021, SSF55021, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51671, ACT, 1 hit
PS00857, PREPHENATE_DEHYDR_1, 1 hit
PS00858, PREPHENATE_DEHYDR_2, 1 hit
PS51171, PREPHENATE_DEHYDR_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FNJ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQTISPAFSC DLKSVIQPNL TAKKARYSHV NGKRVSVRCS YRSESFSFPN 
        60         70         80         90        100
GVGSSRADWQ SSCAILASKV VSAENSSSVA VVNGHSNGSV DLSLVPSKSQ 
       110        120        130        140        150
HNGKPGLIQP LTITDLSPAP SHGSTLRVAY QGVPGAYSEA AAGKAYPNSE 
       160        170        180        190        200
AIPCDQFDVA FQAVELWIAD RAVLPVENSL GGSIHRNYDL LLRHRLHIVG 
       210        220        230        240        250
EVQIPVHHCL LALPGVRTDC ITRVISHPQA LAQTEGSLNK LTPKAAIEAF 
       260        270        280        290        300
HDTAAAAEYI AANNLHDTAA VASARAAELY GLQILADGIQ DDAGNVTRFL 
       310        320        330        340        350
MLARDPIIPR TDRPFKTSIV FAAQEHKGTS VLFKVLSAFA FRNISLTKIE 
       360        370        380        390        400
SRPHQNCPVR VVGDENVGTS KHFEYTFYVD FEASMAEARA QNALAEVQEY 
       410        420 
TSFLRVLGSY PMDMTPWSTL PSEDV
Length:425
Mass (Da):45,928
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B6AD16F3DE48B3F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ411469 mRNA Translation: ABD67755.1
AB006699 Genomic DNA Translation: BAB11669.1
CP002688 Genomic DNA Translation: AED93055.1
AY058097 mRNA Translation: AAL24205.1
AY090235 mRNA Translation: AAL90899.1
AY149958 mRNA Translation: AAN31112.1

NCBI Reference Sequences

More...RefSeqi		NP_197655.1, NM_122169.3

Genome annotation databases

Ensembl plant genome annotation project

More...EnsemblPlantsi		AT5G22630.1; AT5G22630.1; AT5G22630

Database of genes from NCBI RefSeq genomes

More...GeneIDi		832326

Gramene; a comparative resource for plants

More...Gramenei		AT5G22630.1; AT5G22630.1; AT5G22630

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ath:AT5G22630

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ411469 mRNA Translation: ABD67755.1
AB006699 Genomic DNA Translation: BAB11669.1
CP002688 Genomic DNA Translation: AED93055.1
AY058097 mRNA Translation: AAL24205.1
AY090235 mRNA Translation: AAL90899.1
AY149958 mRNA Translation: AAN31112.1
RefSeqiNP_197655.1, NM_122169.3

3D structure databases

AlphaFoldDBiQ9FNJ8
SMRiQ9FNJ8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi17601, 5 interactors
IntActiQ9FNJ8, 5 interactors
STRINGi3702.AT5G22630.1

Proteomic databases

PaxDbiQ9FNJ8
PRIDEiQ9FNJ8
ProteomicsDBi246781

Genome annotation databases

EnsemblPlantsiAT5G22630.1; AT5G22630.1; AT5G22630
GeneIDi832326
GrameneiAT5G22630.1; AT5G22630.1; AT5G22630
KEGGiath:AT5G22630

Organism-specific databases

AraportiAT5G22630
TAIRilocus:2162459, AT5G22630

Phylogenomic databases

eggNOGiKOG2797, Eukaryota
HOGENOMiCLU_035008_4_1_1
InParanoidiQ9FNJ8
OMAiPMDMAPW
OrthoDBi1090069at2759
PhylomeDBiQ9FNJ8

Enzyme and pathway databases

UniPathwayiUPA00121;UER00344
BioCyciARA:AT5G22630-MONOMER
BRENDAi4.2.1.91, 399
SABIO-RKiQ9FNJ8

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9FNJ8

Gene expression databases

ExpressionAtlasiQ9FNJ8, baseline and differential
GenevisibleiQ9FNJ8, AT

Family and domain databases

InterProiView protein in InterPro
IPR045865, ACT-like_dom_sf
IPR002912, ACT_dom
IPR001086, Preph_deHydtase
IPR018528, Preph_deHydtase_CS
PfamiView protein in Pfam
PF00800, PDT, 1 hit
SUPFAMiSSF55021, SSF55021, 1 hit
PROSITEiView protein in PROSITE
PS51671, ACT, 1 hit
PS00857, PREPHENATE_DEHYDR_1, 1 hit
PS00858, PREPHENATE_DEHYDR_2, 1 hit
PS51171, PREPHENATE_DEHYDR_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAROD5_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FNJ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: March 1, 2001
Last modified: May 25, 2022
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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