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Entry version 137 (16 Oct 2019)
Sequence version 1 (01 Mar 2001)
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Protein

DNA repair protein RAD5A

Gene

RAD5A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in error-free postreplication DNA repair or DNA-damage tolerance (DTT) pathway (PubMed:18310306, PubMed:21549648). Required for homologous recombination (HR) induced by DNA double-strand break (DSB) in somatic cells (PubMed:18310306). Required for damage-induced DNA repair, independently of MUS81 and RECQL4A. Plays a role in synthesis-dependent strand annealing (SDSA) but not in single-strand annealing (SSA) (PubMed:20971895). Possesses double-stranded DNA-dependent ATPase activity. Is able to regress replication forks with preference for forks with a leading strand gap. Is able to catalyze branch migration of Holliday junctions and is unaffected by protein blockades (PubMed:27458713).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi419 – 426ATPPROSITE-ProRule annotation8
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri794 – 834RING-typePROSITE-ProRule annotationAdd BLAST41

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Helicase, Hydrolase
Biological processDNA damage, DNA recombination, DNA repair
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair protein RAD5ACurated (EC:3.6.4.-Curated)
Alternative name(s):
Putative SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3-like 2Curated
Short name:
SMARCA3-like protein 2Curated
RAD5 homolog A1 Publication
Short name:
AtRAD5a1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAD5A1 Publication
Synonyms:RAD5Curated
Ordered Locus Names:At5g22750
ORF Names:MDJ22.17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G22750

The Arabidopsis Information Resource

More...
TAIRi
locus:2162504 AT5G22750

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi425 – 426KT → AA: Abolishes double-stranded DNA-dependent ATPase activity. 1 Publication2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000561881 – 1029DNA repair protein RAD5AAdd BLAST1029

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9FNI6

PRoteomics IDEntifications database

More...
PRIDEi
Q9FNI6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9FNI6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9FNI6 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
17613, 5 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT5G22750.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini406 – 622Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST217
Domaini864 – 1029Helicase C-terminalPROSITE-ProRule annotationAdd BLAST166

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi573 – 576DEAH box4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri794 – 834RING-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INU2 Eukaryota
ENOG410XQ1S LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000029930

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9FNI6

KEGG Orthology (KO)

More...
KOi
K15505

Identification of Orthologs from Complete Genome Data

More...
OMAi
RVFMMDP

Database of Orthologous Groups

More...
OrthoDBi
132523at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9FNI6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit
3.40.50.10810, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014905 HIRAN
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271 Helicase_C, 1 hit
PF08797 HIRAN, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00910 HIRAN, 1 hit
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9FNI6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTKVSDDLV STVRSVVGSD YSDMDIIRAL HMANHDPTAA INIIFDTPSF
60 70 80 90 100
AKPDVATPTP SGSNGGKRVD SGLKGCTFGD SGSVGANHRV EEENESVNGG
110 120 130 140 150
GEESVSGNEW WFVGCSELAG LSTCKGRKLK SGDELVFTFP HSKGLKPETT
160 170 180 190 200
PGKRGFGRGR PALRGASDIV RFSTKDSGEI GRIPNEWARC LLPLVRDKKI
210 220 230 240 250
RIEGSCKSAP EALSIMDTIL LSVSVYINSS MFQKHSATSF KTASNTAEES
260 270 280 290 300
MFHPLPNLFR LLGLIPFKKA EFTPEDFYSK KRPLSSKDGS AIPTSLLQLN
310 320 330 340 350
KVKNMNQDAN GDENEQCISD GDLDNIVGVG DSSGLKEMET PHTLLCELRP
360 370 380 390 400
YQKQALHWMT QLEKGNCTDE AATMLHPCWE AYCLADKREL VVYLNSFTGD
410 420 430 440 450
ATIHFPSTLQ MARGGILADA MGLGKTVMTI SLLLAHSWKA ASTGFLCPNY
460 470 480 490 500
EGDKVISSSV DDLTSPPVKA TKFLGFDKRL LEQKSVLQNG GNLIVCPMTL
510 520 530 540 550
LGQWKTEIEM HAKPGSLSVY VHYGQSRPKD AKLLSQSDVV ITTYGVLTSE
560 570 580 590 600
FSQENSADHE GIYAVRWFRI VLDEAHTIKN SKSQISLAAA ALVADRRWCL
610 620 630 640 650
TGTPIQNNLE DLYSLLRFLR IEPWGTWAWW NKLVQKPFEE GDERGLKLVQ
660 670 680 690 700
SILKPIMLRR TKSSTDREGR PILVLPPADA RVIYCELSES ERDFYDALFK
710 720 730 740 750
RSKVKFDQFV EQGKVLHNYA SILELLLRLR QCCDHPFLVM SRGDTAEYSD
760 770 780 790 800
LNKLSKRFLS GKSSGLEREG KDVPSEAFVQ EVVEELRKGE QGECPICLEA
810 820 830 840 850
LEDAVLTPCA HRLCRECLLA SWRNSTSGLC PVCRNTVSKQ ELITAPTESR
860 870 880 890 900
FQVDVEKNWV ESSKITALLE ELEGLRSSGS KSILFSQWTA FLDLLQIPLS
910 920 930 940 950
RNNFSFVRLD GTLSQQQREK VLKEFSEDGS ILVLLMSLKA GGVGINLTAA
960 970 980 990 1000
SNAFVMDPWW NPAVEEQAVM RIHRIGQTKE VKIRRFIVKG TVEERMEAVQ
1010 1020
ARKQRMISGA LTDQEVRSAR IEELKMLFT
Length:1,029
Mass (Da):114,287
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39E72DCB3B713C22
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB006699 Genomic DNA Translation: BAB11681.1
CP002688 Genomic DNA Translation: AED93070.1
AK228695 mRNA Translation: BAF00599.1

NCBI Reference Sequences

More...
RefSeqi
NP_197667.1, NM_122181.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G22750.1; AT5G22750.1; AT5G22750

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
832338

Gramene; a comparative resource for plants

More...
Gramenei
AT5G22750.1; AT5G22750.1; AT5G22750

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G22750

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006699 Genomic DNA Translation: BAB11681.1
CP002688 Genomic DNA Translation: AED93070.1
AK228695 mRNA Translation: BAF00599.1
RefSeqiNP_197667.1, NM_122181.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi17613, 5 interactors
STRINGi3702.AT5G22750.1

Proteomic databases

PaxDbiQ9FNI6
PRIDEiQ9FNI6

Genome annotation databases

EnsemblPlantsiAT5G22750.1; AT5G22750.1; AT5G22750
GeneIDi832338
GrameneiAT5G22750.1; AT5G22750.1; AT5G22750
KEGGiath:AT5G22750

Organism-specific databases

AraportiAT5G22750
TAIRilocus:2162504 AT5G22750

Phylogenomic databases

eggNOGiENOG410INU2 Eukaryota
ENOG410XQ1S LUCA
HOGENOMiHOG000029930
InParanoidiQ9FNI6
KOiK15505
OMAiRVFMMDP
OrthoDBi132523at2759
PhylomeDBiQ9FNI6

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9FNI6

Gene expression databases

ExpressionAtlasiQ9FNI6 baseline and differential
GenevisibleiQ9FNI6 AT

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.40.50.10810, 2 hits
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014905 HIRAN
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF08797 HIRAN, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00910 HIRAN, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSM3L2_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FNI6
Secondary accession number(s): Q0WQK0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2001
Last modified: October 16, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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