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Entry version 124 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Alpha-N-acetylglucosaminidase

Gene

NAGLU

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the remodeling of the N-acetyl-glucosamine residues of proteoglycan complexes during reproductive development. Is essential to promote the first divisions of the zygote.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides.Curated EC:3.2.1.50

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ARA:AT5G13690-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH89, Glycoside Hydrolase Family 89

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-N-acetylglucosaminidaseCurated (EC:3.2.1.50Curated)
Alternative name(s):
N-acetyl-glucosaminidase1 Publication
Short name:
AtNAGLU1 Publication
Protein CYCLOPS 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NAGLU1 Publication
Synonyms:CYL11 Publication
Ordered Locus Names:At5g13690Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G13690

The Arabidopsis Information Resource

More...
TAIRi
locus:2173209, AT5G13690

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality when homozygous, due to embryo development arrested at one-cell stage.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500675177324 – 806Alpha-N-acetylglucosaminidaseSequence analysisAdd BLAST783

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi210N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi288N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi422N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi465N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi532N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi720N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9FNA3

PRoteomics IDEntifications database

More...
PRIDEi
Q9FNA3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
251082

PTM databases

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9FNA3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during early and late male gametogenesis, and in cells of the embryo sac at the time of fertilization. After fertilization, expressed in the embryo, suspensor, and endosperm until the cotyledon stage embryo.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9FNA3, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT5G13690.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9FNA3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 89 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2233, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011988_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9FNA3

Identification of Orthologs from Complete Genome Data

More...
OMAi
QPEFWGP

Database of Orthologous Groups

More...
OrthoDBi
584128at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9FNA3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.379.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017853, Glycoside_hydrolase_SF
IPR029018, Hex-like_dom2
IPR007781, NAGLU
IPR024732, NAGLU_C
IPR024240, NAGLU_N
IPR024733, NAGLU_tim-barrel

The PANTHER Classification System

More...
PANTHERi
PTHR12872, PTHR12872, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05089, NAGLU, 1 hit
PF12972, NAGLU_C, 1 hit
PF12971, NAGLU_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445, SSF51445, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9FNA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHSIKLVLLV LLIISFHSQT VSKHHPTIDG LLDRLDSLLP TSSVQESAAK
60 70 80 90 100
GLLQRLLPTH SQSFELRIIS KDACGGTSCF VIENYDGPGR IGPEILIKGT
110 120 130 140 150
TGVEIASGLH WYLKYKCNAH VSWDKTGGIQ VASVPQPGHL PRIDSKRIFI
160 170 180 190 200
RRPVPWNYYQ NVVTSSYSYV WWGWERWERE IDWMALQGIN LPLAFTGQEA
210 220 230 240 250
IWQKVFKRFN ISKEDLDDYF GGPAFLAWAR MGNLHAWGGP LSKNWLDDQL
260 270 280 290 300
LLQKQILSRM LKFGMTPVLP SFSGNVPSAL RKIYPEANIT RLDNWNTVDG
310 320 330 340 350
DSRWCCTYLL NPSDPLFIEI GEAFIKQQTE EYGEITNIYN CDTFNENTPP
360 370 380 390 400
TSEPEYISSL GAAVYKAMSK GNKNAVWLMQ GWLFSSDSKF WKPPQLKALL
410 420 430 440 450
HSVPFGKMIV LDLYAEVKPI WNKSAQFYGT PYIWCMLHNF GGNIEMYGAL
460 470 480 490 500
DSISSGPVDA RVSKNSTMVG VGMCMEGIEQ NPVVYELTSE MAFRDEKVDV
510 520 530 540 550
QKWLKSYARR RYMKENHQIE AAWEILYHTV YNCTDGIADH NTDFIVKLPD
560 570 580 590 600
WDPSSSVQDD LKQKDSYMIS TGPYETKRRV LFQDKTADLP KAHLWYSTKE
610 620 630 640 650
VIQALKLFLE AGDDLSRSLT YRYDMVDLTR QVLSKLANQV YTEAVTAFVK
660 670 680 690 700
KDIGSLGQLS EKFLELIKDM DVLLASDDNC LLGTWLESAK KLAKNGDERK
710 720 730 740 750
QYEWNARTQV TMWYDSNDVN QSKLHDYANK FWSGLLEDYY LPRARLYFNE
760 770 780 790 800
MLKSLRDKKI FKVEKWRREW IMMSHKWQQS SSEVYPVKAK GDALAISRHL

LSKYFP
Length:806
Mass (Da):92,689
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F8500032F3BCFA2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8B9A7A0A1P8B9A7_ARATH
Alpha-N-acetylglucosaminidase famil...
CYL1 CYCLOPS 1, MSH12.16, MSH12_16, N-ACETYL-GLUCOSAMINIDASE, NAGLU
622Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB006704 Genomic DNA Translation: BAB08696.1
CP002688 Genomic DNA Translation: AED91928.1
AY080811 mRNA Translation: AAL87291.1
AY117179 mRNA Translation: AAM51254.1

NCBI Reference Sequences

More...
RefSeqi
NP_196873.1, NM_121372.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G13690.1; AT5G13690.1; AT5G13690

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
831214

Gramene; a comparative resource for plants

More...
Gramenei
AT5G13690.1; AT5G13690.1; AT5G13690

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G13690

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006704 Genomic DNA Translation: BAB08696.1
CP002688 Genomic DNA Translation: AED91928.1
AY080811 mRNA Translation: AAL87291.1
AY117179 mRNA Translation: AAM51254.1
RefSeqiNP_196873.1, NM_121372.3

3D structure databases

SMRiQ9FNA3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G13690.1

Protein family/group databases

CAZyiGH89, Glycoside Hydrolase Family 89

PTM databases

MetOSiteiQ9FNA3

Proteomic databases

PaxDbiQ9FNA3
PRIDEiQ9FNA3
ProteomicsDBi251082

Genome annotation databases

EnsemblPlantsiAT5G13690.1; AT5G13690.1; AT5G13690
GeneIDi831214
GrameneiAT5G13690.1; AT5G13690.1; AT5G13690
KEGGiath:AT5G13690

Organism-specific databases

AraportiAT5G13690
TAIRilocus:2173209, AT5G13690

Phylogenomic databases

eggNOGiKOG2233, Eukaryota
HOGENOMiCLU_011988_2_1_1
InParanoidiQ9FNA3
OMAiQPEFWGP
OrthoDBi584128at2759
PhylomeDBiQ9FNA3

Enzyme and pathway databases

BioCyciARA:AT5G13690-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9FNA3

Gene expression databases

ExpressionAtlasiQ9FNA3, baseline and differential

Family and domain databases

Gene3Di3.30.379.10, 1 hit
InterProiView protein in InterPro
IPR017853, Glycoside_hydrolase_SF
IPR029018, Hex-like_dom2
IPR007781, NAGLU
IPR024732, NAGLU_C
IPR024240, NAGLU_N
IPR024733, NAGLU_tim-barrel
PANTHERiPTHR12872, PTHR12872, 1 hit
PfamiView protein in Pfam
PF05089, NAGLU, 1 hit
PF12972, NAGLU_C, 1 hit
PF12971, NAGLU_N, 1 hit
SUPFAMiSSF51445, SSF51445, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAGLU_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FNA3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 6, 2016
Last sequence update: March 1, 2001
Last modified: December 2, 2020
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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