Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 106 (18 Sep 2019)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Dicarboxylate transporter 2.1, chloroplastic

Gene

DIT2-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glutamate/malate translocator involved with DIT1 in primary ammonia assimilation and in the re-assimilation of ammonia generated by the photorespiratory pathway. Exports the end product of ammonia assimilation, glutamate, from plastids to the cytosol. The precursor for ammonia assimilation, 2-oxoglutarate, is imported from the cytosol by DIT1.2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.41 mM for malate1 Publication
  2. KM=0.23 mM for oxaloacetate1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processTransport

    Enzyme and pathway databases

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q9FMF7

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Dicarboxylate transporter 2.1, chloroplastic
    Alternative name(s):
    AtpDCT1
    Glutamate/malate translocator
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:DIT2-1
    Synonyms:DIT2
    Ordered Locus Names:At5g64290
    ORF Names:MSJ1.13
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

    Organism-specific databases

    Arabidopsis Information Portal

    More...
    Araporti
    AT5G64290

    The Arabidopsis Information Resource

    More...
    TAIRi
    locus:2173358 AT5G64290

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
    Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
    Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
    Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
    Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
    Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
    Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
    Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
    Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
    Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
    Transmembranei483 – 503HelicalSequence analysisAdd BLAST21
    Transmembranei537 – 557HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Chloroplast, Membrane, Plastid, Plastid inner membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Non-viable seedlings under normal atmospheric conditions, but grow normally under non-photorespiratory conditions high CO2 conditions.1 Publication

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi206G → E in dct; photorespiratory phenotype leading to non-viable seedlings under normal atmospheric conditions. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 68ChloroplastSequence analysisAdd BLAST68
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000041918469 – 563Dicarboxylate transporter 2.1, chloroplasticAdd BLAST495

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9FMF7

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9FMF7

    PTM databases

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q9FMF7

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in roots, rosette and cauline leaves, stems, flowers and siliques.2 Publications

    Gene expression databases

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9FMF7 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9FMF7 AT

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    21792, 1 interactor

    Protein interaction database and analysis system

    More...
    IntActi
    Q9FMF7, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    3702.AT5G64290.1

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410IK3C Eukaryota
    COG0471 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000117912

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9FMF7

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    PQAWRYF

    Database of Orthologous Groups

    More...
    OrthoDBi
    842017at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9FMF7

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR030676 CitT-rel
    IPR001898 SLC13A/DASS

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR42826 PTHR42826, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00939 Na_sulph_symp, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00785 dass, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9FMF7-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MESFALHSLS TTATSTLLSH HHHHHPSRLS LLRRTSSRSP PSTISLRSLS
    60 70 80 90 100
    VQPLSFPLLK PIPRFSTRIA AAPQDNAPPP PPPSPSPSPS PQGAKLIPLI
    110 120 130 140 150
    LSISVGLILR FAVPVPEGVT PQGWQLLSIF LSTIAGLVLS PLPVGAWAFI
    160 170 180 190 200
    GLTASIVTKT LSFSAAFSAF TSEVIWLIVI SFFFARGFVK TGLGDRIATY
    210 220 230 240 250
    FVKWLGKSTL GLSYGLTLSE ALIAPAMPST TARAGGIFLP IIKSLSLSAG
    260 270 280 290 300
    SKPNDSSSRK LGSYLIQSQF QCAGNSSALF LTAAAQNLLC LKLAEELGVV
    310 320 330 340 350
    ISNPWVSWFK AASLPAIISL LCTPLILYKL YPPETKDTPE APGIAATKLK
    360 370 380 390 400
    QMGPVTKNEW IMVGTMLLAV TLWICGETLG IPSVVAAMIG LSILLVLGVL
    410 420 430 440 450
    NWDDCLSEKS AWDTLAWFAV LVGMAGQLTN LGVVTWMSDC VAKVLQSLSL
    460 470 480 490 500
    SWPAAFGLLQ AAYFFIHYLF ASQTGHVGAL FSAFLAMHIA AGVPGILAAL
    510 520 530 540 550
    ALAYNTNLFG ALTHYSSGQA AVYYGAGYVD LPDVFKIGFV MATINAIIWG
    560
    VVGTFWWKFL GLY
    Length:563
    Mass (Da):59,992
    Last modified:March 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBAE5C455D5FF88A0
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB008268 Genomic DNA Translation: BAB09860.1
    CP002688 Genomic DNA Translation: AED97866.1
    AY056329 mRNA Translation: AAL07178.1
    BT000654 mRNA Translation: AAN31801.1
    BT015925 mRNA Translation: AAU95461.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_201234.1, NM_125825.3

    Genome annotation databases

    Ensembl plant genome annotation project

    More...
    EnsemblPlantsi
    AT5G64290.1; AT5G64290.1; AT5G64290

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    836550

    Gramene; a comparative resource for plants

    More...
    Gramenei
    AT5G64290.1; AT5G64290.1; AT5G64290

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ath:AT5G64290

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB008268 Genomic DNA Translation: BAB09860.1
    CP002688 Genomic DNA Translation: AED97866.1
    AY056329 mRNA Translation: AAL07178.1
    BT000654 mRNA Translation: AAN31801.1
    BT015925 mRNA Translation: AAU95461.1
    RefSeqiNP_201234.1, NM_125825.3

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi21792, 1 interactor
    IntActiQ9FMF7, 1 interactor
    STRINGi3702.AT5G64290.1

    PTM databases

    SwissPalmiQ9FMF7

    Proteomic databases

    PaxDbiQ9FMF7
    PRIDEiQ9FMF7

    Genome annotation databases

    EnsemblPlantsiAT5G64290.1; AT5G64290.1; AT5G64290
    GeneIDi836550
    GrameneiAT5G64290.1; AT5G64290.1; AT5G64290
    KEGGiath:AT5G64290

    Organism-specific databases

    AraportiAT5G64290
    TAIRilocus:2173358 AT5G64290

    Phylogenomic databases

    eggNOGiENOG410IK3C Eukaryota
    COG0471 LUCA
    HOGENOMiHOG000117912
    InParanoidiQ9FMF7
    OMAiPQAWRYF
    OrthoDBi842017at2759
    PhylomeDBiQ9FMF7

    Enzyme and pathway databases

    SABIO-RKiQ9FMF7

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:Q9FMF7

    Gene expression databases

    ExpressionAtlasiQ9FMF7 baseline and differential
    GenevisibleiQ9FMF7 AT

    Family and domain databases

    InterProiView protein in InterPro
    IPR030676 CitT-rel
    IPR001898 SLC13A/DASS
    PANTHERiPTHR42826 PTHR42826, 1 hit
    PfamiView protein in Pfam
    PF00939 Na_sulph_symp, 1 hit
    TIGRFAMsiTIGR00785 dass, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIT21_ARATH
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FMF7
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
    Last sequence update: March 1, 2001
    Last modified: September 18, 2019
    This is version 106 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again