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Entry version 121 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Dihydroneopterin aldolase 2

Gene

FOLB2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conversion of 7,8-dihydroneopterin into 6-hydroxymethyl-7,8-dihydropterin, a biosynthetic precursor of the vitamin tetrahydrofolate. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.Curated
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 7,8-dihydroneopterin aldolase (AXX17_At5g62530), 7,8-dihydroneopterin aldolase (AN1_LOCUS13611), 7,8-dihydroneopterin aldolase (AXX17_At3g11690), 7,8-dihydroneopterin aldolase (AN1_LOCUS26608), 7,8-dihydroneopterin aldolase (AT9943_LOCUS10746), 7,8-dihydroneopterin aldolase (AXX17_At3g23310), 7,8-dihydroneopterin aldolase (AT9943_LOCUS11694), Dihydroneopterin aldolase 2 (FOLB2), 7,8-dihydroneopterin aldolase (AT9943_LOCUS10746), Probable dihydroneopterin aldolase 3 (FOLB3), 7,8-dihydroneopterin aldolase (AN1_LOCUS12498), Dihydroneopterin aldolase 1 (FOLB1), 7,8-dihydroneopterin aldolase (At3g11750)
  4. 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (C24_LOCUS5837), 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (AN1_LOCUS5947), Folate synthesis bifunctional protein (CytHPPK/DHPS), 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (AT9943_LOCUS5028), 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (AT9943_LOCUS17084), 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (AXX17_At4g34400), 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (At1g69190), Folate synthesis bifunctional protein, mitochondrial (MitHPPK/DHPS)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei29SubstrateBy similarity1
Binding sitei61SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei107Proton donor/acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processFolate biosynthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ARA:AT5G62980-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00077;UER00154

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dihydroneopterin aldolase 2Curated (EC:4.1.2.251 Publication)
Short name:
DHNA2Curated
Alternative name(s):
7,8-dihydroneopterin aldolase
AtFolB21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FOLB21 Publication
Ordered Locus Names:At5g62980Imported
ORF Names:MJH22.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G62980

The Arabidopsis Information Resource

More...
TAIRi
locus:2166300, AT5G62980

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004314461 – 131Dihydroneopterin aldolase 2Add BLAST131

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9FM54

PRoteomics IDEntifications database

More...
PRIDEi
Q9FM54

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
228915

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in roots, leaves, stems and siliques.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9FM54, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9FM54, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooctamer.

Forms a hollow cylinder assembled from two ring-shaped tetramers.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT5G62980.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9FM54

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni80 – 81Substrate bindingBy similarity2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DHNA family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RZV8, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_112632_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9FM54

Identification of Orthologs from Complete Genome Data

More...
OMAi
YHGCLVE

Database of Orthologous Groups

More...
OrthoDBi
1383549at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9FM54

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00534, DHNA_DHNTPE, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1130.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006156, Dihydroneopterin_aldolase
IPR006157, FolB_dom
IPR043133, GTP-CH-I_C/QueF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02152, FolB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00905, FolB, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00525, folB, 1 hit
TIGR00526, folB_dom, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9FM54-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKDMAMMGD KLILRGLKFY GFHGAIPEEK TLGQMFMLDI DAWMCLKKAG
60 70 80 90 100
LSDNLADSVS YVDIYNVAKE VVEGSSRNLL ERVAGLIASK TLEISPRITA
110 120 130
VRVKLWKPNV ALIQSTIDYL GVEIFRDRAT E
Length:131
Mass (Da):14,685
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i194C4731D1554D48
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB009051 Genomic DNA Translation: BAB08841.1
CP002688 Genomic DNA Translation: AED97682.1
CP002688 Genomic DNA Translation: ANM70563.1
BT003970 mRNA Translation: AAO42014.1
BT014860 mRNA Translation: AAT41843.1

NCBI Reference Sequences

More...
RefSeqi
NP_001332160.1, NM_001345573.1
NP_201103.1, NM_125692.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G62980.1; AT5G62980.1; AT5G62980
AT5G62980.2; AT5G62980.2; AT5G62980

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
836418

Gramene; a comparative resource for plants

More...
Gramenei
AT5G62980.1; AT5G62980.1; AT5G62980
AT5G62980.2; AT5G62980.2; AT5G62980

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G62980

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009051 Genomic DNA Translation: BAB08841.1
CP002688 Genomic DNA Translation: AED97682.1
CP002688 Genomic DNA Translation: ANM70563.1
BT003970 mRNA Translation: AAO42014.1
BT014860 mRNA Translation: AAT41843.1
RefSeqiNP_001332160.1, NM_001345573.1
NP_201103.1, NM_125692.4

3D structure databases

SMRiQ9FM54
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G62980.1

Proteomic databases

PaxDbiQ9FM54
PRIDEiQ9FM54
ProteomicsDBi228915

Genome annotation databases

EnsemblPlantsiAT5G62980.1; AT5G62980.1; AT5G62980
AT5G62980.2; AT5G62980.2; AT5G62980
GeneIDi836418
GrameneiAT5G62980.1; AT5G62980.1; AT5G62980
AT5G62980.2; AT5G62980.2; AT5G62980
KEGGiath:AT5G62980

Organism-specific databases

AraportiAT5G62980
TAIRilocus:2166300, AT5G62980

Phylogenomic databases

eggNOGiENOG502RZV8, Eukaryota
HOGENOMiCLU_112632_1_0_1
InParanoidiQ9FM54
OMAiYHGCLVE
OrthoDBi1383549at2759
PhylomeDBiQ9FM54

Enzyme and pathway databases

UniPathwayiUPA00077;UER00154
BioCyciARA:AT5G62980-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9FM54

Gene expression databases

ExpressionAtlasiQ9FM54, baseline and differential
GenevisibleiQ9FM54, AT

Family and domain databases

CDDicd00534, DHNA_DHNTPE, 1 hit
Gene3Di3.30.1130.10, 1 hit
InterProiView protein in InterPro
IPR006156, Dihydroneopterin_aldolase
IPR006157, FolB_dom
IPR043133, GTP-CH-I_C/QueF
PfamiView protein in Pfam
PF02152, FolB, 1 hit
SMARTiView protein in SMART
SM00905, FolB, 1 hit
TIGRFAMsiTIGR00525, folB, 1 hit
TIGR00526, folB_dom, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFOLB2_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FM54
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 7, 2015
Last sequence update: March 1, 2001
Last modified: December 2, 2020
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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