Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1

Gene

PTEN1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein tyrosine phosphatase that exhibits also lipid phosphatase activity. Can use phosphatidylinositol substrates such as PtdIns(3,4,5)P3 as substrate. Pollen-specific phosphatase required for pollen development.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation1 Publication
Phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 4,5-bisphosphate + phosphate.1 Publication

Activity regulationi

Inhibited by vanadate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • phosphatidylinositol dephosphorylation Source: UniProtKB
  • pollen development Source: TAIR

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processLipid metabolism, Phospholipid metabolism

Enzyme and pathway databases

BioCyciARA:AT5G39400-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1Curated (EC:3.1.3.48PROSITE-ProRule annotation1 Publication, EC:3.1.3.671 Publication)
Alternative name(s):
Protein PHOSPHATASE AND TENSIN HOMOLOG 11 Publication
Short name:
AtPTEN11 Publication
Gene namesi
Name:PTEN11 Publication
Ordered Locus Names:At5g39400Imported
ORF Names:MUL8.80Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G39400
TAIRilocus:2175713 AT5G39400

Pathology & Biotechi

Disruption phenotypei

Pollen cell death after mitosis, during the late stage of development, characterized by collapsed pollen grains, shrunken, with highly deformed exines and reduced size.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi152C → S: Loss of phosphatase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004351671 – 412Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1Add BLAST412

Proteomic databases

PaxDbiQ9FLZ5

Expressioni

Tissue specificityi

Expressed exclusively in pollen grains during the late stage of development (at protein level).2 Publications

Gene expression databases

ExpressionAtlasiQ9FLZ5 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ9FLZ5, 2 interactors
STRINGi3702.AT5G39400.1

Structurei

3D structure databases

ProteinModelPortaliQ9FLZ5
SMRiQ9FLZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 211Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST170
Domaini239 – 396C2 tensin-typePROSITE-ProRule annotationAdd BLAST158

Sequence similaritiesi

Belongs to the PTEN phosphatase protein family.1 Publication

Phylogenomic databases

eggNOGiKOG2283 Eukaryota
COG2453 LUCA
HOGENOMiHOG000152553
InParanoidiQ9FLZ5
KOiK01110
OMAiELARGCC
OrthoDBiEOG093604TH
PhylomeDBiQ9FLZ5

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit
SMARTiView protein in SMART
SM01326 PTEN_C2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FLZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLKLSRGPV KEKSPLEFTR VHILTYFTTN SYLRNLVSKK RRRLIIGGYD
60 70 80 90 100
LDMSYISDKL LAMSFPAERM RAVYRNPLWQ VKSVLDMRHP DHYKVYNLCI
110 120 130 140 150
EESYDPDNFY GRVERFPFDD NHVPSLKMIQ LFCESVHSWL SLDPKNIAVV
160 170 180 190 200
HCMAGKGRTG LMVSAYLVYG GMSAEEALEM YASRRTTNNN GVSIPSQRRY
210 220 230 240 250
VKYWSDLLSF SKKGPPEVKL PQEHSRELLR IRLYDTANVD SVFFVVSELQ
260 270 280 290 300
EVPNEMYRPS VELARGCCRQ FKKGYCRSSS PRYYISHVNC DSEEDEEVTD
310 320 330 340 350
GEEPHLVVQM DTESSIIDEK TCLDFYFDKP VRVSGDIRIT FYQKMIGSRL
360 370 380 390 400
FYTCFNTAFI TNGLLQFSIG ELDKVGGNGR SISGPDFSLE LLFGPACSKF
410
GKFLSRDDLS LS
Length:412
Mass (Da):47,355
Last modified:March 1, 2001 - v1
Checksum:i4F9F0FD80F115ABB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ490172 mRNA Translation: CAD35363.1
AB009054 Genomic DNA Translation: BAB11013.1
CP002688 Genomic DNA Translation: AED94429.1
AK118115 mRNA Translation: BAC42741.1
BT005560 mRNA Translation: AAO63980.1
RefSeqiNP_198756.2, NM_123302.4
UniGeneiAt.30348
At.49110

Genome annotation databases

EnsemblPlantsiAT5G39400.1; AT5G39400.1; AT5G39400
GeneIDi833936
GrameneiAT5G39400.1; AT5G39400.1; AT5G39400
KEGGiath:AT5G39400

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ490172 mRNA Translation: CAD35363.1
AB009054 Genomic DNA Translation: BAB11013.1
CP002688 Genomic DNA Translation: AED94429.1
AK118115 mRNA Translation: BAC42741.1
BT005560 mRNA Translation: AAO63980.1
RefSeqiNP_198756.2, NM_123302.4
UniGeneiAt.30348
At.49110

3D structure databases

ProteinModelPortaliQ9FLZ5
SMRiQ9FLZ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9FLZ5, 2 interactors
STRINGi3702.AT5G39400.1

Proteomic databases

PaxDbiQ9FLZ5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G39400.1; AT5G39400.1; AT5G39400
GeneIDi833936
GrameneiAT5G39400.1; AT5G39400.1; AT5G39400
KEGGiath:AT5G39400

Organism-specific databases

AraportiAT5G39400
TAIRilocus:2175713 AT5G39400

Phylogenomic databases

eggNOGiKOG2283 Eukaryota
COG2453 LUCA
HOGENOMiHOG000152553
InParanoidiQ9FLZ5
KOiK01110
OMAiELARGCC
OrthoDBiEOG093604TH
PhylomeDBiQ9FLZ5

Enzyme and pathway databases

BioCyciARA:AT5G39400-MONOMER

Miscellaneous databases

PROiPR:Q9FLZ5

Gene expression databases

ExpressionAtlasiQ9FLZ5 baseline and differential

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit
SMARTiView protein in SMART
SM01326 PTEN_C2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTEN1_ARATH
AccessioniPrimary (citable) accession number: Q9FLZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2016
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again