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UniProtKB - Q9FLH2 (Q9FLH2_ARATH)

Entry version 140 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
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Protein
Submitted name:

2-oxoglutarate dehydrogenase, E1 component

Gene

MPA24.10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

thiamine diphosphateARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseARBA annotation
LigandThiamine pyrophosphateARBA annotation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		ARA:AT5G65750-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
2-oxoglutarate dehydrogenase, E1 componentImported
Submitted name:
Putative 2-oxoglutarate dehydrogenase E1 componentImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MPA24.10Imported
Synonyms:MPA24_10Imported
Ordered Locus Names:At5g65750Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...Araporti		AT5G65750

The Arabidopsis Information Resource

More...TAIRi		locus:2170000, AT5G65750

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q9FLH2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		185266

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		3702.AT5G65750.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9FLH2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini639 – 852Transket_pyrInterPro annotationAdd BLAST214

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0450, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004709_1_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		RDSYCRT

Database of Orthologous Groups

More...OrthoDBi		134699at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.11610, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032106, 2-oxogl_dehyd_N
IPR011603, 2oxoglutarate_DH_E1
IPR001017, DH_E1
IPR031717, KGD_C
IPR042179, KGD_C_sf
IPR029061, THDP-binding
IPR005475, Transketolase-like_Pyr-bd

The PANTHER Classification System

More...PANTHERi		PTHR23152, PTHR23152, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16078, 2-oxogl_dehyd_N, 1 hit
PF00676, E1_dh, 1 hit
PF16870, OxoGdeHyase_C, 1 hit
PF02779, Transket_pyr, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000157, Oxoglu_dh_E1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00861, Transket_pyr, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52518, SSF52518, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00239, 2oxo_dh_E1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9FLH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVWFRIGSSV AKLAIRRTLS QSRCGSYATR TRVLPCQTRC FHSTILKSKA 
        60         70         80         90        100
ESAAPVPRPV PLSKLTDSFL DGTSSVYLEE LQRAWEADPN SVDESWDNFF 
       110        120        130        140        150
RNFVGQASTS PGISGQTIQE SMRLLLLVRA YQVNGHMKAK LDPLGLEKRE 
       160        170        180        190        200
IPEDLTPGLY GFTEADLDRE FFLGVWRMSG FLSENRPVQT LRSILSRLEQ 
       210        220        230        240        250
AYCGTIGYEY MHIADRDKCN WLRDKIETPT PRQYNSERRM VIYDRLTWST 
       260        270        280        290        300
QFENFLATKW TTAKRFGLEG AESLIPGMKE MFDRSADLGV ENIVIGMPHR 
       310        320        330        340        350
GRLNVLGNVV RKPLRQIFSE FSGGTRPVDE VGLYTGTGDV KYHLGTSYDR 
       360        370        380        390        400
PTRGGKHLHL SLVANPSHLE AVDPVVIGKT RAKQYYTKDE NRTKNMGILI 
       410        420        430        440        450
HGDGSFAGQG VVYETLHLSA LPNYCTGGTV HIVVNNQVAF TTDPREGRSS 
       460        470        480        490        500
QYCTDVAKAL SAPIFHVNAD DIEAVVHACE LAAEWRQTFH SDVVVDLVCY 
       510        520        530        540        550
RRFGHNEIDE PSFTQPKMYK VIRSHPSSLQ IYQEKLLQSG QVTQEDIDKI 
       560        570        580        590        600
QKKVSSILNE EYEASKDYIP QKRDWLASHW TGFKSPEQIS RIRNTGVKPE 
       610        620        630        640        650
ILKNVGKAIS TFPENFKPHR GVKRVYEQRA QMIESGEGID WGLGEALAFA 
       660        670        680        690        700
TLVVEGNHVR LSGQDVERGT FSHRHSVLHD QETGEEYCPL DHLIKNQDPE 
       710        720        730        740        750
MFTVSNSSLS EFGVLGFELG YSMENPNSLV IWEAQFGDFA NGAQVMFDQF 
       760        770        780        790        800
ISSGEAKWLR QTGLVVLLPH GYDGQGPEHS SGRLERFLQM SDDNPYVIPE 
       810        820        830        840        850
MDPTLRKQIQ ECNWQVVNVT TPANYFHVLR RQIHRDFRKP LIVMAPKNLL 
       860        870        880        890        900
RHKQCVSNLS EFDDVKGHPG FDKQGTRFKR LIKDQSGHSD LEEGIRRLVL 
       910        920        930        940        950
CSGKVYYELD EERKKSETKD VAICRVEQLC PFPYDLIQRE LKRYPNAEIV 
       960        970        980        990       1000
WCQEEPMNMG GYQYIALRLC TAMKALQRGN FNDIKYVGRL PSAATATGFY 
      1010       1020 
QLHVKEQTDL VKKALQPDPI TPVIP
Length:1,025
Mass (Da):116,399
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59AC1EE4C20650A8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY074374 mRNA Translation: AAL67070.1
AY096631 mRNA Translation: AAM20281.1
CP002688 Genomic DNA Translation: AED98101.1
AB010075 Genomic DNA Translation: BAB10682.1

NCBI Reference Sequences

More...RefSeqi		NP_201376.1, NM_125972.5

Genome annotation databases

Ensembl plant genome annotation project

More...EnsemblPlantsi		AT5G65750.1; AT5G65750.1; AT5G65750

Database of genes from NCBI RefSeq genomes

More...GeneIDi		836704

Gramene; a comparative resource for plants

More...Gramenei		AT5G65750.1; AT5G65750.1; AT5G65750

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ath:AT5G65750

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY074374 mRNA Translation: AAL67070.1
AY096631 mRNA Translation: AAM20281.1
CP002688 Genomic DNA Translation: AED98101.1
AB010075 Genomic DNA Translation: BAB10682.1
RefSeqiNP_201376.1, NM_125972.5

3D structure databases

SMRiQ9FLH2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G65750.1

Proteomic databases

PRIDEiQ9FLH2
ProteomicsDBi185266

Genome annotation databases

EnsemblPlantsiAT5G65750.1; AT5G65750.1; AT5G65750
GeneIDi836704
GrameneiAT5G65750.1; AT5G65750.1; AT5G65750
KEGGiath:AT5G65750

Organism-specific databases

AraportiAT5G65750
TAIRilocus:2170000, AT5G65750

Phylogenomic databases

eggNOGiKOG0450, Eukaryota
HOGENOMiCLU_004709_1_0_1
OMAiRDSYCRT
OrthoDBi134699at2759

Enzyme and pathway databases

BioCyciARA:AT5G65750-MONOMER

Family and domain databases

Gene3Di3.40.50.11610, 1 hit
InterProiView protein in InterPro
IPR032106, 2-oxogl_dehyd_N
IPR011603, 2oxoglutarate_DH_E1
IPR001017, DH_E1
IPR031717, KGD_C
IPR042179, KGD_C_sf
IPR029061, THDP-binding
IPR005475, Transketolase-like_Pyr-bd
PANTHERiPTHR23152, PTHR23152, 1 hit
PfamiView protein in Pfam
PF16078, 2-oxogl_dehyd_N, 1 hit
PF00676, E1_dh, 1 hit
PF16870, OxoGdeHyase_C, 1 hit
PF02779, Transket_pyr, 1 hit
PIRSFiPIRSF000157, Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861, Transket_pyr, 1 hit
SUPFAMiSSF52518, SSF52518, 2 hits
TIGRFAMsiTIGR00239, 2oxo_dh_E1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9FLH2_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FLH2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: December 2, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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