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Entry version 139 (16 Oct 2019)
Sequence version 2 (23 Nov 2004)
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Protein

Serine/threonine-protein kinase ATR

Gene

ATR

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2-arrest response to double-strand breaks. May also be involved in the meiosis process. Required for the basal expression of RNR1 (ribonucleotide reductase large subunit). Acts in concert with telomerase to maintain telomeric DNA tracts. Not required for telomere length homeostasis. Required for effective immune responses that involve activation of DNA damage responses (PubMed:24207055).4 Publications

Miscellaneous

Loss-of-function mutations (T-DNA insertion) are hypersensitive to replication antagonists, including UV light, aphidicolin, and hydroxyurea, and are defective in G2 checkpoints induced by these agents.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, DNA damage, DNA repair, Plant defense
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase ATR (EC:2.7.11.1)
Short name:
AtATR
Alternative name(s):
Ataxia telangiectasia-mutated and Rad3-related homolog
DNA repair protein ATR
Rad3-like protein
Short name:
AtRAD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATR
Synonyms:RAD3
Ordered Locus Names:At5g40820
ORF Names:MHK7.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G40820

The Arabidopsis Information Resource

More...
TAIRi
locus:2164481 AT5G40820

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Suppressor of sni1 mutation symptoms including the accumulation of DNA damage leading to a constitutively activated DNA damage responses (DDR) and increased basal expression of pathogenesis-related (PR) genes.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000888381 – 2702Serine/threonine-protein kinase ATRAdd BLAST2702

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9FKS4

PRoteomics IDEntifications database

More...
PRIDEi
Q9FKS4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Strongly induced by replication blocking agents (UVB, aphidicolin and hydroxyurea) but only mildly induced by DNA damaging agents (gamma-radiation) (PubMed:15075397). Negatively regulated by the key immune regulator SNI1 (PubMed:24207055).2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9FKS4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9FKS4 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT5G40820.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9FKS4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1646 – 2255FATPROSITE-ProRule annotationAdd BLAST610
Domaini2392 – 2638PI3K/PI4KPROSITE-ProRule annotationAdd BLAST247
Domaini2670 – 2702FATCPROSITE-ProRule annotationAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0890 Eukaryota
COG5032 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000030210

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9FKS4

KEGG Orthology (KO)

More...
KOi
K06640

Identification of Orthologs from Complete Genome Data

More...
OMAi
NGLNHES

Database of Orthologous Groups

More...
OrthoDBi
80538at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9FKS4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR012993 UME

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF08064 UME, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SM00802 UME, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9FKS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKDDNNLSS LVHELRERVA ASASTPANNL RHSSGDEDAL EIRFRAVIPN
60 70 80 90 100
LLNTYVVPSL GNGREVTAVL KLVGHTARNI PGVFYHGTPS AILPVIARII
110 120 130 140 150
PFFAEPEFVP GHGVLLETVG SLLMLLRSNS RKAYRIFFHD ALQAIQDMQP
160 170 180 190 200
IASLHSIEPE VCESHIPFRC FCMSFSGIGG DLPDANKPRD GDGLVLNLLG
210 220 230 240 250
ANRWQPFATC ILKLICKCLT EGTLYVQGLI HTSFFKAACS LVCCGGADVQ
260 270 280 290 300
MACFEFATLV GSILTFNILP HVALIQSIIL LLSADEGLPV YRNTIYDSTI
310 320 330 340 350
GRFLTAVYSS CSDAAVKLTA ESLVLVLSHA LQRTKSEELK ASLCSAYVRI
360 370 380 390 400
VKSCPPCIWK IHCLLELLHL PEPCFQLIEC FKAVLIVLGP GCVRVETTKC
410 420 430 440 450
GSHTSATSDR PVQGINAGKK RHIEDESTYK RKRQKVGDDI RRGVYFAPEF
460 470 480 490 500
ADETDGKDAA SLREMLISTV ESLKPPPAGP SLSQTESSIV ALSMLTNAFC
510 520 530 540 550
FCPWTDMTHR LFNQMYAWIP WIAGQVEETN PIMFDISIYL EGIHNLLLVG
560 570 580 590 600
VDPQYEYTSK GNDLVAIQFL LKLPWTHYML FKTPSSLVKS KCLSVGIWTK
610 620 630 640 650
LGLQDGSDFD IFSWSLSDDF EQVQAVAAIS MPLKVLFSGL GALLHMFPKL
660 670 680 690 700
EHLLEEKELM IKKAIPQSLG FLSCLYGSST TDSEKTACHL LLHEDLKKDE
710 720 730 740 750
TLNSLLQGFR CSKCDKFIER EDEKHFRIIE TPEMVKLKMD HHRDYFNLQS
760 770 780 790 800
LYFNLLYDES SEETQLACVE VIRRILGHTS PDILVRTRSQ WIRCLQYLLV
810 820 830 840 850
HVNTDVREAF CAQIGIFVQH PIVSCLFLSE DATEKSCERN FFNLIEHSLA
860 870 880 890 900
AAKDLLVIQT LLETTAEVMV AVDVTSELFL ICLFLLIDQL DHPNLIVRIN
910 920 930 940 950
ASKLINRSCY IHVKGGFATL LSTASHIQNE LFDNLSVRLT SRPNVVREFA
960 970 980 990 1000
EAVLGVETEE LVRKMVPAVL PKLLVYWQEN AQAANTLNEL AKLIDTDVVP
1010 1020 1030 1040 1050
LIVNWLPRVL AFALNQEEDK NLLSVLQLYH SQIGSDNQEI FAAALPALLD
1060 1070 1080 1090 1100
ELVCFVDIAD TPETDRRLQR LPDAIKKISK VLTNAEDLPG FLQNHFVGLL
1110 1120 1130 1140 1150
NSIDRKMLHA DDIFLQKQAL KRIKLLIEMM GHYLSTYVPK LMVLLMHAIE
1160 1170 1180 1190 1200
KDALQSEGLL VLHFFTRKLA DVSPSSIKYV ISQIFAALIP FLEKEKEGPH
1210 1220 1230 1240 1250
VYLDEVVKIL EELVLKNRDI VKEHICEFPL LPSIPSLGEL NNAIQEARGL
1260 1270 1280 1290 1300
MSLKDQLRDI VNGMKHENLN VRYMVACELS KLLYNRNEDV AALIAGELVS
1310 1320 1330 1340 1350
DMEILSSLIT YLLQGCAEES RTTVGQRLKL VCADCLGAIG AIDPAKVRVA
1360 1370 1380 1390 1400
SCSRFKIQCS DDDLIFELIH KHLARAFRAA QDTIIQDSAA LAIQELLKIA
1410 1420 1430 1440 1450
GCEPSLAGNV VVLTPQEHVQ VNVSGSRRCG GNNEVKDRGQ KLWDRFSNYV
1460 1470 1480 1490 1500
KELIAPCLTS RFQLPNVSDP GSAGPIYRPS MSFRRWLSYW IRKLTAFATG
1510 1520 1530 1540 1550
SRVSIFAACR GIVRHDMQTA TYLLPYLVLD VVCHGTEAAR LSISEEILSV
1560 1570 1580 1590 1600
LDAAASENSG VTINSFGVGQ SEVCVQAVFT LLDNLGQWVD DVKQGVALSS
1610 1620 1630 1640 1650
SLQSSGGRQV APKSKDQVSN STTEQDHLLV QCKYVLELLL AIPKVTLARA
1660 1670 1680 1690 1700
SFRCQAYARS LMYLESHVRG KSGSLNPAAE KTGIFENADV SSLMGIYSCL
1710 1720 1730 1740 1750
DEPDGLSGFA SLSKSLNLQD QLLINKKSGN WADVFTACEQ ALQMEPTSVQ
1760 1770 1780 1790 1800
RHSDVLNCLL NMCHHQTMVT HVDGLISRVP EYKKTWCTQG VQAAWRLGKW
1810 1820 1830 1840 1850
DLMDEYLDGA DAEGLLFSSS DSNASFDRDV AKILHAMMKK DQYSVAEGIA
1860 1870 1880 1890 1900
ISKQALIAPL AAAGMDSYTR AYPFVVKLHL LRELEDFQAV LNGDSYLEKS
1910 1920 1930 1940 1950
FSTSDQVFSK AVDNWENRLR FTQSSLWTRE PLLAFRRLVF GASGLGAQVG
1960 1970 1980 1990 2000
NCWLQYAKLC RLAGHYETAH RAILEAQASG APNVHMEKAK LLWITKRSDS
2010 2020 2030 2040 2050
AIIELQQSLL NMPEGVVDST VISSINSLLM APPNPEPTVR NTQSFKEKKD
2060 2070 2080 2090 2100
VAKTLLLYSK WIHHSGQKQK KDVLNLYTQV KELLPWEKGY FHLAKYYDEL
2110 2120 2130 2140 2150
YVDARKCQQE SSVFSSAGSK KGSVSSNLST EKAGWDYLFK GMYFYAKALH
2160 2170 2180 2190 2200
SGHKNLFQAL PRLLTLWFDF GTIYKTSGSA GNKELKSTHM KIMSLMRGCL
2210 2220 2230 2240 2250
KDLPTYQWLT VLPQLVSRIC HQNADTVLMV KNIITSVLHQ FPQQGLWIMA
2260 2270 2280 2290 2300
AVSKSTVPAR REAAAEIIQG ARKGFNQSDR GHNLFIQFAS LTDHFIKLCF
2310 2320 2330 2340 2350
HGGQPRSKVI NIATEFSALK RMMPLDIIMP IQQSLTISLP AFHMNNNERH
2360 2370 2380 2390 2400
SASVFSGSDL PTISGIADEA EILSSLQRPK KIILLGNDGI EYPFLCKPKD
2410 2420 2430 2440 2450
DLRKDARMME FTAMINRLLS KYPESRRRKL YIRTFAVAPL TEDCGLVEWV
2460 2470 2480 2490 2500
PHTRGLRHIL QDIYISCGKF DRQKTNPQIK RIYDQCAVKK EYEMLKTKIL
2510 2520 2530 2540 2550
PMFPPVFHKW FLTTFSEPAA WFRSRVAYAH TTAVWSMVGH IVGLGDRHGE
2560 2570 2580 2590 2600
NILFDSTSGD CVHVDFSCLF DKGLQLEKPE LVPFRLTQNM IDGLGITGYE
2610 2620 2630 2640 2650
GIFMRVCEIT LTVLRTHRET LMSILETFIH DPLVEWTKSH KSSGVEVQNP
2660 2670 2680 2690 2700
HAQRAISSIE ARLQGVVVGV PLPVEGQARR LIADAVSLEN LGKMYIWWMP

WF
Length:2,702
Mass (Da):302,366
Last modified:November 23, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDCC88C59F50E23D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1R7T394A0A1R7T394_ARATH
Ataxia telangiectasia-mutated and R...
ATR ATATR, ATRAD3, MHK7.5, MHK7_5, At5g40820
2,703Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB11344 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti152 – 153AS → GIH in BAA92828 (Ref. 1) Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB040133 mRNA Translation: BAA92828.1
AB011477 Genomic DNA Translation: BAB11344.1 Sequence problems.
CP002688 Genomic DNA Translation: AED94599.1
CP002688 Genomic DNA Translation: ANM71086.1
CP002688 Genomic DNA Translation: ANM71087.1

NCBI Reference Sequences

More...
RefSeqi
NP_001332642.1, NM_001344357.1
NP_001332643.1, NM_001344356.1
NP_198898.2, NM_123447.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G40820.1; AT5G40820.1; AT5G40820
AT5G40820.3; AT5G40820.3; AT5G40820
AT5G40820.4; AT5G40820.4; AT5G40820

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
834082

Gramene; a comparative resource for plants

More...
Gramenei
AT5G40820.1; AT5G40820.1; AT5G40820
AT5G40820.3; AT5G40820.3; AT5G40820
AT5G40820.4; AT5G40820.4; AT5G40820

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G40820

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040133 mRNA Translation: BAA92828.1
AB011477 Genomic DNA Translation: BAB11344.1 Sequence problems.
CP002688 Genomic DNA Translation: AED94599.1
CP002688 Genomic DNA Translation: ANM71086.1
CP002688 Genomic DNA Translation: ANM71087.1
RefSeqiNP_001332642.1, NM_001344357.1
NP_001332643.1, NM_001344356.1
NP_198898.2, NM_123447.3

3D structure databases

SMRiQ9FKS4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G40820.1

Proteomic databases

PaxDbiQ9FKS4
PRIDEiQ9FKS4

Genome annotation databases

EnsemblPlantsiAT5G40820.1; AT5G40820.1; AT5G40820
AT5G40820.3; AT5G40820.3; AT5G40820
AT5G40820.4; AT5G40820.4; AT5G40820
GeneIDi834082
GrameneiAT5G40820.1; AT5G40820.1; AT5G40820
AT5G40820.3; AT5G40820.3; AT5G40820
AT5G40820.4; AT5G40820.4; AT5G40820
KEGGiath:AT5G40820

Organism-specific databases

AraportiAT5G40820
TAIRilocus:2164481 AT5G40820

Phylogenomic databases

eggNOGiKOG0890 Eukaryota
COG5032 LUCA
HOGENOMiHOG000030210
InParanoidiQ9FKS4
KOiK06640
OMAiNGLNHES
OrthoDBi80538at2759
PhylomeDBiQ9FKS4

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9FKS4

Gene expression databases

ExpressionAtlasiQ9FKS4 baseline and differential
GenevisibleiQ9FKS4 AT

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR012993 UME
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF08064 UME, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SM00802 UME, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATR_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FKS4
Secondary accession number(s): Q9MAZ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: October 16, 2019
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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