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Protein

Transcriptional regulator STERILE APETALA

Gene

SAP

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator involved in the specification of floral identity. Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in the external flower organs in association with APETALA2 and other repressors. Is required to maintain floral meristem identity in concert with AGAMOUS. Interacts also with APETALA2 to ensure the normal development of ovule.

Miscellaneous

Mutations in the SAP gene result in the ectopic expression of AGAMOUS, leading to partial homeotic transformation of the external floral organs. Mutations affect equally ovule development and cause floral sterility.

GO - Molecular functioni

  • DNA binding transcription factor activity Source: TAIR

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • flower development Source: TAIR
  • megasporogenesis Source: TAIR
  • positive regulation of organ growth Source: TAIR
  • protein catabolic process Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processDifferentiation, Flowering, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator STERILE APETALA
Gene namesi
Name:SAP
Ordered Locus Names:At5g35770
ORF Names:MXH1.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G35770
TAIRilocus:2177271 AT5G35770

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975861 – 446Transcriptional regulator STERILE APETALAAdd BLAST446

Proteomic databases

PaxDbiQ9FKH1
PRIDEiQ9FKH1

Expressioni

Tissue specificityi

Expressed in inflorescence and floral meristems, young floral organ primordia, and later in ovule primordia.

Gene expression databases

ExpressionAtlasiQ9FKH1 baseline and differential
GenevisibleiQ9FKH1 AT

Interactioni

Protein-protein interaction databases

BioGridi18809, 6 interactors
IntActiQ9FKH1, 8 interactors
STRINGi3702.AT5G35770.1

Structurei

3D structure databases

ProteinModelPortaliQ9FKH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 17Gly/Ser-richAdd BLAST16

Phylogenomic databases

eggNOGiENOG410IFX4 Eukaryota
ENOG410YBZW LUCA
HOGENOMiHOG000154254
InParanoidiQ9FKH1
OMAiWRIMVID
OrthoDBiEOG09360B17
PhylomeDBiQ9FKH1

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
SUPFAMiSSF50978 SSF50978, 2 hits
SSF81383 SSF81383, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FKH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSSSSSDN GAGGSGGVFE APSPSRPRRG ANDVWPEPFL ESLAVQVAVN
60 70 80 90 100
ASTSAGLLAA APALANVFRV CTTWHAVSRS DHLWQLLSRQ VWARTHLMHD
110 120 130 140 150
TWRDEFIYRH RTARNFRTRT HTYFTLQFDP SDVDEPDSLS CRCLTLSDLY
160 170 180 190 200
LAAGFADGTV RLFLLNNRLH VRTLRPPLRD RFGRFSRAVS GIVISDSRLT
210 220 230 240 250
FATMDGDIHV AEIDGVGHTR TAYAGDIVND GALVDFTGCG RWWVGLFAGV
260 270 280 290 300
PGRAFHIWDC NSEETTFVGG TLTDPEAVMG WHTLTELTTS LGRLRISGNE
310 320 330 340 350
TAVACTRWRI MVIDLRNQGV IIGEDEEQRR GLIVTGFDAN DEAYVRLDSR
360 370 380 390 400
GNASVRRVNT QQTVCEFRVS GAAQRRVMGC VNRLHALMCA GGIMRVWEVE
410 420 430 440
RGEYLYSIRE RVGEVDAIVA DDRHVAVASA SSTAQSIIHL WDFGAL
Length:446
Mass (Da):49,306
Last modified:March 1, 2001 - v1
Checksum:iD099C0F2DED475F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75H → L in CAA11128 (PubMed:10215627).Curated1
Sequence conflicti153A → G in CAA11128 (PubMed:10215627).Curated1
Sequence conflicti328Q → P in CAA11128 (PubMed:10215627).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223125 mRNA Translation: CAA11128.1
AB011485 Genomic DNA Translation: BAB09276.1
CP002688 Genomic DNA Translation: AED94017.1
PIRiT51368
RefSeqiNP_198426.1, NM_122968.2
UniGeneiAt.416

Genome annotation databases

EnsemblPlantsiAT5G35770.1; AT5G35770.1; AT5G35770
GeneIDi833556
GrameneiAT5G35770.1; AT5G35770.1; AT5G35770
KEGGiath:AT5G35770

Similar proteinsi

Entry informationi

Entry nameiSAP_ARATH
AccessioniPrimary (citable) accession number: Q9FKH1
Secondary accession number(s): Q9ZRQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names

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