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Protein

Peroxidase 72

Gene

PER72

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei69Transition state stabilizerPROSITE-ProRule annotation1
Active sitei73Proton acceptorPROSITE-ProRule annotation1
Metal bindingi74Calcium 1PROSITE-ProRule annotation1
Metal bindingi77Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi79Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi81Calcium 1PROSITE-ProRule annotation1
Metal bindingi83Calcium 1PROSITE-ProRule annotation1
Binding sitei170Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi200Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi201Calcium 2PROSITE-ProRule annotation1
Metal bindingi252Calcium 2PROSITE-ProRule annotation1
Metal bindingi255Calcium 2PROSITE-ProRule annotation1
Metal bindingi260Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • hydrogen peroxide catabolic process Source: UniProtKB-KW
  • lignin biosynthetic process Source: TAIR
  • response to oxidative stress Source: InterPro

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G66390-MONOMER

Protein family/group databases

PeroxiBasei238 AtPrx72

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 72 (EC:1.11.1.7)
Short name:
Atperox P72
Alternative name(s):
ATP6a
PRXR8
Gene namesi
Name:PER72
Synonyms:P72
Ordered Locus Names:At5g66390
ORF Names:K1F13.4, K1L20.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G66390
TAIRilocus:2154925 AT5G66390

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002373724 – 336Peroxidase 72Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 122PROSITE-ProRule annotation
Disulfide bondi75 ↔ 80PROSITE-ProRule annotation
Disulfide bondi128 ↔ 329PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi207 ↔ 239PROSITE-ProRule annotation
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9FJZ9
PRIDEiQ9FJZ9

Expressioni

Tissue specificityi

Slightly expressed in roots.1 Publication

Inductioni

Up-regulated transiently by a cold treatment.1 Publication

Gene expression databases

ExpressionAtlasiQ9FJZ9 baseline and differential
GenevisibleiQ9FJZ9 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G66390.1

Structurei

3D structure databases

ProteinModelPortaliQ9FJZ9
SMRiQ9FJZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIQM Eukaryota
ENOG410YA1B LUCA
HOGENOMiHOG000237557
InParanoidiQ9FJZ9
KOiK00430
OMAiPPVSWGQ
OrthoDBiEOG09360H0D
PhylomeDBiQ9FJZ9

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FJZ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKSLNILIA ALSLIAFSPF CLCSKAYGSG GYLFPQFYDQ SCPKAQEIVQ
60 70 80 90 100
SIVAKAFEHD PRMPASLLRL HFHDCFVKGC DASILLDSSG TIISEKRSNP
110 120 130 140 150
NRNSARGFEL IEEIKHALEQ ECPETVSCAD ILALAARDST VITGGPSWEV
160 170 180 190 200
PLGRRDARGA SLSGSNNDIP APNNTFQTIL TKFKRQGLDL VDLVSLSGSH
210 220 230 240 250
TIGNSRCTSF RQRLYNQSGN GKPDMTLSQY YATLLRQRCP RSGGDQTLFF
260 270 280 290 300
LDFATPFKFD NHYFKNLIMY KGLLSSDEIL FTKNKQSKEL VELYAENQEA
310 320 330
FFEQFAKSMV KMGNISPLTG AKGEIRRICR RVNHAY
Length:336
Mass (Da):37,427
Last modified:March 1, 2001 - v1
Checksum:i4DAD91C4693A0833
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151P → R (Ref. 1) Curated1
Sequence conflicti151P → R (Ref. 2) Curated1
Sequence conflicti307K → I (Ref. 1) Curated1
Sequence conflicti307K → I (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98320 mRNA Translation: CAA66964.1
X98774 mRNA Translation: CAA67310.1
AB013389 Genomic DNA Translation: BAB10915.1
CP002688 Genomic DNA Translation: AED98207.1
BT008314 mRNA Translation: AAP37673.1
RefSeqiNP_201440.1, NM_126037.5
UniGeneiAt.25460

Genome annotation databases

EnsemblPlantsiAT5G66390.1; AT5G66390.1; AT5G66390
GeneIDi836771
GrameneiAT5G66390.1; AT5G66390.1; AT5G66390
KEGGiath:AT5G66390

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98320 mRNA Translation: CAA66964.1
X98774 mRNA Translation: CAA67310.1
AB013389 Genomic DNA Translation: BAB10915.1
CP002688 Genomic DNA Translation: AED98207.1
BT008314 mRNA Translation: AAP37673.1
RefSeqiNP_201440.1, NM_126037.5
UniGeneiAt.25460

3D structure databases

ProteinModelPortaliQ9FJZ9
SMRiQ9FJZ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G66390.1

Protein family/group databases

PeroxiBasei238 AtPrx72

Proteomic databases

PaxDbiQ9FJZ9
PRIDEiQ9FJZ9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G66390.1; AT5G66390.1; AT5G66390
GeneIDi836771
GrameneiAT5G66390.1; AT5G66390.1; AT5G66390
KEGGiath:AT5G66390

Organism-specific databases

AraportiAT5G66390
TAIRilocus:2154925 AT5G66390

Phylogenomic databases

eggNOGiENOG410IIQM Eukaryota
ENOG410YA1B LUCA
HOGENOMiHOG000237557
InParanoidiQ9FJZ9
KOiK00430
OMAiPPVSWGQ
OrthoDBiEOG09360H0D
PhylomeDBiQ9FJZ9

Enzyme and pathway databases

BioCyciARA:AT5G66390-MONOMER

Miscellaneous databases

PROiPR:Q9FJZ9

Gene expression databases

ExpressionAtlasiQ9FJZ9 baseline and differential
GenevisibleiQ9FJZ9 AT

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPER72_ARATH
AccessioniPrimary (citable) accession number: Q9FJZ9
Secondary accession number(s): Q43736
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: March 1, 2001
Last modified: October 10, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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