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Entry version 99 (17 Jun 2020)
Sequence version 1 (01 Mar 2001)
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Protein

5-oxoprolinase

Gene

OXP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Acts in the glutathione degradation pathway.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 5-oxoprolinase (ATP-hydrolyzing) activity Source: TAIR
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ARA:AT5G37830-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.2.9 399

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5-oxoprolinase (EC:3.5.2.9)
Alternative name(s):
5-oxo-L-prolinase
Short name:
5-OPase
Protein OXOPROLINASE 1
Pyroglutamase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OXP1
Ordered Locus Names:At5g37830
ORF Names:K22F20.70
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G37830

The Arabidopsis Information Resource

More...
TAIRi
locus:2156030 AT5G37830

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No morphological phenotype, but high accumulation of 5-oxoproline and decreased concentration of glutamate.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003806741 – 12665-oxoprolinaseAdd BLAST1266

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9FIZ7

PRoteomics IDEntifications database

More...
PRIDEi
Q9FIZ7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
249367

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9FIZ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in roots, stems, leaves, flowers and siliques.

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9FIZ7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9FIZ7 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
19012, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT5G37830.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9FIZ7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi148 – 152Poly-Asp5
Compositional biasi1258 – 1263Poly-Gly6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the oxoprolinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JXJJ Eukaryota
KOG1939 Eukaryota
COG0145 LUCA
COG0146 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002157_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9FIZ7

KEGG Orthology (KO)

More...
KOi
K01469

Identification of Orthologs from Complete Genome Data

More...
OMAi
CLMHGYT

Database of Orthologous Groups

More...
OrthoDBi
62698at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9FIZ7

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008040 Hydant_A_N
IPR002821 Hydantoinase_A
IPR003692 Hydantoinase_B

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05378 Hydant_A_N, 1 hit
PF01968 Hydantoinase_A, 1 hit
PF02538 Hydantoinase_B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9FIZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTVIEGKLR FCIDRGGTFT DVYAEIPGHS DGHVLKLLSV DPSNYDDAPV
60 70 80 90 100
EGIRRILEEY TGKKIPRTSK IPTDKIQWIR MGTTVATNAL LERKGERIAL
110 120 130 140 150
CVTKGFKDLL QIGNQARPDI FDLTVAKPSN LYEEVIEVDE RVVLALEDDD
160 170 180 190 200
DDEGSLIKGV SGEFLRVVKP FDGEGLKPLL KGLLDKGISC LAVVLMHSYT
210 220 230 240 250
YPKHEMDVEK LALEMGFRHV SLSSALTPMV RAVPRGLTAT VDAYLTPVIK
260 270 280 290 300
EYLSGFISKF DDDLGKVNVL FMQSDGGLAP ESRFSGHKAV LSGPAGGVVG
310 320 330 340 350
YSQTLFGLET EKPLIGFDMG GTSTDVSRYD GSYEQVIETQ IAGTIIQAPQ
360 370 380 390 400
LDINTVAAGG GSKLKFQFGA FRVGPDSVGA HPGPVCYRKG GELAVTDANL
410 420 430 440 450
VLGFVIPDYF PSIFGPNEDQ PLDVAATREA FEKLAGQINI YRKSQDPSAK
460 470 480 490 500
DMSVEEIAMG FVSVANETMC RPIRQLTEMK GHETKNHALA CFGGAGPQHA
510 520 530 540 550
CAIARSLGMK EVLVHRYCGI LSAYGMGLAD VIEDAQEPYS AVYGPESLSE
560 570 580 590 600
VFRRETVLLR EVREKLQEQG FGDGNISTET YLNLRYDGTD TAIMVKGKKT
610 620 630 640 650
GDGSAFDYAA EFLKLFEQEY GFKLQNRNLL ICDVRVRGIG VTSILKPRAV
660 670 680 690 700
EAAPVTPKVE RHYKVYFEGG WHDTPLFKLE NLGFGHEILG PAIIMNGNST
710 720 730 740 750
VIVEPQCKAI ITKYGNIKIE VEPATSSVKL AENVADVVQL SIFNHRFMGI
760 770 780 790 800
AEQMGRTLQR TSISTNIKER LDFSCALFSP DGGLVANAPH VPVHLGAMSS
810 820 830 840 850
TVRWQLKHWG ENLNEGDVLV TNHPCAGGSH LPDITVITPV FDKGKLVFFV
860 870 880 890 900
ASRGHHAEVG GITPGSMPPF SKAIWEEGAA IKAFKVVEKG VFQEEGIVKL
910 920 930 940 950
LQFPSSDETT TKIPGTRRIQ DNLSDLQAQI AANQRGISLI KELIEQYGLG
960 970 980 990 1000
TVQAYMKYVQ LNAEEAVREM LKSVANRVSS ETPNSRVGNS VTIEEEDYMD
1010 1020 1030 1040 1050
DGSIIHLKLT IDADKGEASF DFTGTSPEVY GNWNAPEAVT SAAVIYCLRC
1060 1070 1080 1090 1100
LVNVDIPLNQ GCLAPVEIRI PAGSFLSPSE KAAVVGGNVL TSQRVTDVVL
1110 1120 1130 1140 1150
TAFQACACSQ GCMNNLTFGD DTFGYYETIG GGCGAGPTWN GTSGVQCHMT
1160 1170 1180 1190 1200
NTRMTDPEIF EQRYPVLLHR FGLRENSGGN GLHKGGDGLV REIEFRKPVV
1210 1220 1230 1240 1250
VSILSERRVH SPRGLNGGQN GLRGANYLIT KDKRRIYLGG KNTVHVEAGE
1260
ILQILTPGGG GFGSNI
Length:1,266
Mass (Da):137,531
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77E862B3E4EB7395
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB016873 Genomic DNA Translation: BAB10362.1
CP002688 Genomic DNA Translation: AED94237.1
AY102096 mRNA Translation: AAM26666.1
BT004510 mRNA Translation: AAO42756.1
AK228904 mRNA Translation: BAF00793.1

NCBI Reference Sequences

More...
RefSeqi
NP_198599.1, NM_123142.5

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G37830.1; AT5G37830.1; AT5G37830

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
833761

Gramene; a comparative resource for plants

More...
Gramenei
AT5G37830.1; AT5G37830.1; AT5G37830

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G37830

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016873 Genomic DNA Translation: BAB10362.1
CP002688 Genomic DNA Translation: AED94237.1
AY102096 mRNA Translation: AAM26666.1
BT004510 mRNA Translation: AAO42756.1
AK228904 mRNA Translation: BAF00793.1
RefSeqiNP_198599.1, NM_123142.5

3D structure databases

SMRiQ9FIZ7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi19012, 1 interactor
STRINGi3702.AT5G37830.1

PTM databases

iPTMnetiQ9FIZ7

Proteomic databases

PaxDbiQ9FIZ7
PRIDEiQ9FIZ7
ProteomicsDBi249367

Genome annotation databases

EnsemblPlantsiAT5G37830.1; AT5G37830.1; AT5G37830
GeneIDi833761
GrameneiAT5G37830.1; AT5G37830.1; AT5G37830
KEGGiath:AT5G37830

Organism-specific databases

AraportiAT5G37830
TAIRilocus:2156030 AT5G37830

Phylogenomic databases

eggNOGiENOG410JXJJ Eukaryota
KOG1939 Eukaryota
COG0145 LUCA
COG0146 LUCA
HOGENOMiCLU_002157_0_1_1
InParanoidiQ9FIZ7
KOiK01469
OMAiCLMHGYT
OrthoDBi62698at2759
PhylomeDBiQ9FIZ7

Enzyme and pathway databases

BioCyciARA:AT5G37830-MONOMER
BRENDAi3.5.2.9 399

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9FIZ7

Gene expression databases

ExpressionAtlasiQ9FIZ7 baseline and differential
GenevisibleiQ9FIZ7 AT

Family and domain databases

InterProiView protein in InterPro
IPR008040 Hydant_A_N
IPR002821 Hydantoinase_A
IPR003692 Hydantoinase_B
PfamiView protein in Pfam
PF05378 Hydant_A_N, 1 hit
PF01968 Hydantoinase_A, 1 hit
PF02538 Hydantoinase_B, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOPLA_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FIZ7
Secondary accession number(s): Q0WQ06
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 1, 2001
Last modified: June 17, 2020
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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