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UniProtKB - Q9FIS2 (ZIP12_ARATH)
Protein
Probable zinc transporter 12
Gene
ZIP12
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Zinc transporter involved in zinc uptake in roots. Targeted by BZIP23 transcription factor in response to zinc-deficient conditions.
1 PublicationGO - Molecular functioni
- zinc ion transmembrane transporter activity Source: GO_Central
GO - Biological processi
- zinc ion transmembrane transport Source: UniProtKB
Keywordsi
Biological process | Ion transport, Transport, Zinc transport |
Ligand | Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Probable zinc transporter 12Alternative name(s): ZRT/IRT-like protein 12 |
Gene namesi | Name:ZIP12 Ordered Locus Names:At5g62160 ORF Names:MTG10.19 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G62160 |
TAIRi | locus:2174098, AT5G62160 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 50 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 51 – 71 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 72 – 77 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 78 – 98 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 99 – 116 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 138 – 200 | CytoplasmicSequence analysisAdd BLAST | 63 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 222 – 231 | ExtracellularSequence analysis | 10 | |
Transmembranei | 232 – 252 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 253 – 261 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 262 – 282 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 283 – 302 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 303 – 323 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 324 – 334 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 335 – 355 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000041649 | 26 – 355 | Probable zinc transporter 12Add BLAST | 330 |
Proteomic databases
PaxDbi | Q9FIS2 |
Expressioni
Inductioni
By zinc-deficiency.1 Publication
Gene expression databases
ExpressionAtlasi | Q9FIS2, baseline and differential |
Genevisiblei | Q9FIS2, AT |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 156 – 183 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 213 – 214 | Heavy metals bindingBy similarity | 2 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1558, Eukaryota |
HOGENOMi | CLU_027089_3_0_1 |
OMAi | HAHTGSA |
OrthoDBi | 981397at2759 |
PhylomeDBi | Q9FIS2 |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP IPR004698, Zn/Fe_permease_fun/pln |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
TIGRFAMsi | TIGR00820, zip, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9FIS2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRFRKTLVS AFVLCLVIFP LLVSAAEEEN QCGGSKGGSA AEKASALKYK
60 70 80 90 100
IIAFFSILIA GVFGVCLPIF GLKTESNFFM YVKAFAAGVI LATGFVHILP
110 120 130 140 150
DATESLTSSC LGEEPPWGDF PMTGLVAMAA SILTMLIESF ASGYLNRSRL
160 170 180 190 200
AKEGKTLPVS TGGEEEHAHT GSAHTHASQG HSHGSLLIPQ DDDHIDMRKK
210 220 230 240 250
IVTQILELGI VVHSVIIGIS LGASPSVSTI KPLIAAITFH QLFEGFGLGG
260 270 280 290 300
CISEAKFRVK KIWVMLMFFA LTAPIGIGIG IGVAEIYNEN SPMALKVSGF
310 320 330 340 350
LNATASGILI YMALVDLVAP LFMNQKTQSS MKIQVACSVS LVVGAGLMSL
LAIWA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF369914 Genomic DNA Translation: AAL38437.1 AB016880 Genomic DNA Translation: BAB10178.1 CP002688 Genomic DNA Translation: AED97571.1 |
RefSeqi | NP_201022.1, NM_125609.2 |
Genome annotation databases
EnsemblPlantsi | AT5G62160.1; AT5G62160.1; AT5G62160 |
GeneIDi | 836336 |
Gramenei | AT5G62160.1; AT5G62160.1; AT5G62160 |
KEGGi | ath:AT5G62160 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF369914 Genomic DNA Translation: AAL38437.1 AB016880 Genomic DNA Translation: BAB10178.1 CP002688 Genomic DNA Translation: AED97571.1 |
RefSeqi | NP_201022.1, NM_125609.2 |
3D structure databases
SMRi | Q9FIS2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT5G62160.1 |
Proteomic databases
PaxDbi | Q9FIS2 |
Genome annotation databases
EnsemblPlantsi | AT5G62160.1; AT5G62160.1; AT5G62160 |
GeneIDi | 836336 |
Gramenei | AT5G62160.1; AT5G62160.1; AT5G62160 |
KEGGi | ath:AT5G62160 |
Organism-specific databases
Araporti | AT5G62160 |
TAIRi | locus:2174098, AT5G62160 |
Phylogenomic databases
eggNOGi | KOG1558, Eukaryota |
HOGENOMi | CLU_027089_3_0_1 |
OMAi | HAHTGSA |
OrthoDBi | 981397at2759 |
PhylomeDBi | Q9FIS2 |
Miscellaneous databases
PROi | PR:Q9FIS2 |
Gene expression databases
ExpressionAtlasi | Q9FIS2, baseline and differential |
Genevisiblei | Q9FIS2, AT |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP IPR004698, Zn/Fe_permease_fun/pln |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
TIGRFAMsi | TIGR00820, zip, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ZIP12_ARATH | |
Accessioni | Q9FIS2Primary (citable) accession number: Q9FIS2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2003 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families