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Entry version 125 (11 Dec 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Probable WRKY transcription factor 2

Gene

WRKY2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor. Regulates WOX8 and WOX9 expression and basal cell division patterns during early embryogenesis. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Required to repolarize the zygote from a transient symmetric state.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi298ZincBy similarity1
Metal bindingi303ZincBy similarity1
Metal bindingi326Zinc; via pros nitrogenBy similarity1
Metal bindingi328Zinc; via tele nitrogenBy similarity1
Metal bindingi512ZincBy similarity1
Metal bindingi517ZincBy similarity1
Metal bindingi541Zinc; via pros nitrogenBy similarity1
Metal bindingi543Zinc; via tele nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi267 – 331WRKY 1PROSITE-ProRule annotationAdd BLAST65
DNA bindingi481 – 546WRKY 2PROSITE-ProRule annotationAdd BLAST66

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable WRKY transcription factor 21 Publication
Alternative name(s):
WRKY DNA-binding protein 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WRKY21 Publication
Ordered Locus Names:At5g56270Imported
ORF Names:K24C1.9, MXK23.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G56270

The Arabidopsis Information Resource

More...
TAIRi
locus:2177596 AT5G56270

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Strong defects in embryo development.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001336451 – 687Probable WRKY transcription factor 2Add BLAST687

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9FG77

PRoteomics IDEntifications database

More...
PRIDEi
Q9FG77

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9FG77

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Low expression in senescent leaves (PubMed:11722756). Expressed in both the unfertilized egg cell and the pollen tube (PubMed:21316593).2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9FG77 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9FG77 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
20970, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9FG77, 2 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT5G56270.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9FG77

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi437 – 446Poly-GlySequence analysis10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WRKY group I family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFRA Eukaryota
ENOG4112BTF LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000242409

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9FG77

KEGG Orthology (KO)

More...
KOi
K18835

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGMSEAM

Database of Orthologous Groups

More...
OrthoDBi
478624at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9FG77

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.25.80, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003657 WRKY_dom
IPR036576 WRKY_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03106 WRKY, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00774 WRKY, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF118290 SSF118290, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50811 WRKY, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9FG77-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGFDENVAV MGEWVPRSPS PGTLFSSAIG EEKSSKRVLE RELSLNHGQV
60 70 80 90 100
IGLEEDTSSN HNKDSSQSNV FRGGLSERIA ARAGFNAPRL NTENIRTNTD
110 120 130 140 150
FSIDSNLRSP CLTISSPGLS PATLLESPVF LSNPLAQPSP TTGKFPFLPG
160 170 180 190 200
VNGNALSSEK AKDEFFDDIG ASFSFHPVSR SSSSFFQGTT EMMSVDYGNY
210 220 230 240 250
NNRSSSHQSA EEVKPGSENI ESSNLYGIET DNQNGQNKTS DVTTNTSLET
260 270 280 290 300
VDHQEEEEEQ RRGDSMAGGA PAEDGYNWRK YGQKLVKGSE YPRSYYKCTN
310 320 330 340 350
PNCQVKKKVE RSREGHITEI IYKGAHNHLK PPPNRRSGMQ VDGTEQVEQQ
360 370 380 390 400
QQQRDSAATW VSCNNTQQQG GSNENNVEEG STRFEYGNQS GSIQAQTGGQ
410 420 430 440 450
YESGDPVVVV DASSTFSNDE DEDDRGTHGS VSLGYDGGGG GGGGEGDESE
460 470 480 490 500
SKRRKLEAFA AEMSGSTRAI REPRVVVQTT SDVDILDDGY RWRKYGQKVV
510 520 530 540 550
KGNPNPRSYY KCTAPGCTVR KHVERASHDL KSVITTYEGK HNHDVPAARN
560 570 580 590 600
SSHGGGGDSG NGNSGGSAAV SHHYHNGHHS EPPRGRFDRQ VTTNNQSPFS
610 620 630 640 650
RPFSFQPHLG PPSGFSFGLG QTGLVNLSMP GLAYGQGKMP GLPHPYMTQP
660 670 680
VGMSEAMMQR GMEPKVEPVS DSGQSVYNQI MSRLPQI
Length:687
Mass (Da):74,561
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD47EAB1FB0C6335F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF418308 mRNA Translation: AAL13039.1
AB026656 Genomic DNA Translation: BAB08871.1
CP002688 Genomic DNA Translation: AED96743.1
AY096493 mRNA Translation: AAM20132.1
AY123006 mRNA Translation: AAM67539.1

NCBI Reference Sequences

More...
RefSeqi
NP_200438.1, NM_125010.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G56270.1; AT5G56270.1; AT5G56270

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
835726

Gramene; a comparative resource for plants

More...
Gramenei
AT5G56270.1; AT5G56270.1; AT5G56270

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G56270

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418308 mRNA Translation: AAL13039.1
AB026656 Genomic DNA Translation: BAB08871.1
CP002688 Genomic DNA Translation: AED96743.1
AY096493 mRNA Translation: AAM20132.1
AY123006 mRNA Translation: AAM67539.1
RefSeqiNP_200438.1, NM_125010.3

3D structure databases

SMRiQ9FG77
ModBaseiSearch...

Protein-protein interaction databases

BioGridi20970, 2 interactors
IntActiQ9FG77, 2 interactors
STRINGi3702.AT5G56270.1

PTM databases

iPTMnetiQ9FG77

Proteomic databases

PaxDbiQ9FG77
PRIDEiQ9FG77

Genome annotation databases

EnsemblPlantsiAT5G56270.1; AT5G56270.1; AT5G56270
GeneIDi835726
GrameneiAT5G56270.1; AT5G56270.1; AT5G56270
KEGGiath:AT5G56270

Organism-specific databases

AraportiAT5G56270
TAIRilocus:2177596 AT5G56270

Phylogenomic databases

eggNOGiENOG410IFRA Eukaryota
ENOG4112BTF LUCA
HOGENOMiHOG000242409
InParanoidiQ9FG77
KOiK18835
OMAiVGMSEAM
OrthoDBi478624at2759
PhylomeDBiQ9FG77

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9FG77

Gene expression databases

ExpressionAtlasiQ9FG77 baseline and differential
GenevisibleiQ9FG77 AT

Family and domain databases

Gene3Di2.20.25.80, 2 hits
InterProiView protein in InterPro
IPR003657 WRKY_dom
IPR036576 WRKY_dom_sf
PfamiView protein in Pfam
PF03106 WRKY, 2 hits
SMARTiView protein in SMART
SM00774 WRKY, 2 hits
SUPFAMiSSF118290 SSF118290, 2 hits
PROSITEiView protein in PROSITE
PS50811 WRKY, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWRKY2_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FG77
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2001
Last modified: December 11, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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