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Entry version 120 (12 Aug 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Cytochrome b561, DM13 and DOMON domain-containing protein At5g54830

Gene

At5g54830

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a catecholamine-responsive trans-membrane electron transporter.1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi689Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi723Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi754Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi796Iron (heme axial ligand)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome b561, DM13 and DOMON domain-containing protein At5g54830
Alternative name(s):
Protein b561A.tha1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:At5g54830
ORF Names:MBG8_9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G54830

The Arabidopsis Information Resource

More...
TAIRi
locus:2160220, AT5G54830

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei685 – 705Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei730 – 750Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei754 – 774Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei795 – 815Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei829 – 849Helical; Name=5Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043047225 – 907Cytochrome b561, DM13 and DOMON domain-containing protein At5g54830Add BLAST883

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9FFU6

PRoteomics IDEntifications database

More...
PRIDEi
Q9FFU6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
241117

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9FFU6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9FFU6, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT5G54830.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 139DM13PROSITE-ProRule annotationAdd BLAST109
Domaini184 – 329DOMON 1PROSITE-ProRule annotationAdd BLAST146
Domaini524 – 645DOMON 2PROSITE-ProRule annotationAdd BLAST122
Domaini653 – 850Cytochrome b561PROSITE-ProRule annotationAdd BLAST198

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

DOMON domain could bind catecholamines and thereby could regulate the cytochrome b561 domain function (PubMed:15022831). DOMON domain could bind one heme b (PubMed:19386804).2 Publications

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4293, Eukaryota
KOG4731, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_340217_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9FFU6

Identification of Orthologs from Complete Genome Data

More...
OMAi
FYVSSVH

Database of Orthologous Groups

More...
OrthoDBi
599276at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9FFU6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006593, Cyt_b561/ferric_Rdtase_TM
IPR019545, DM13_domain
IPR005018, DOMON_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03188, Cytochrom_B561, 1 hit
PF10517, DM13, 1 hit
PF03351, DOMON, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00665, B561, 1 hit
SM00686, DM13, 1 hit
SM00664, DoH, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50939, CYTOCHROME_B561, 1 hit
PS51549, DM13, 1 hit
PS50836, DOMON, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9FFU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCDQRPNLLG SLVLLGFFIF FVNGEECSNS SSLIGHESEF KMLQHQLRGV
60 70 80 90 100
FTVVDDCSFR VSRFDMLSGS EVHWWGAMSS DFDNMTNDGF VISDQKLNQT
110 120 130 140 150
FKNSSFIVRL LGNVTWDKLG VVSVWDLPTA SDFGHVLLSN ATESDTSKAE
160 170 180 190 200
SPPSESNDVA PGKSNNSEPF KAPTMFDNCK KLSDKYRLRW SLNAEKGYVD
210 220 230 240 250
IGLEATTGLL NYMAFGWAKP NSTSNLMLNA DVVVTGIRED GFPFADDFYI
260 270 280 290 300
TESSVCSVKE GTATGVCPDT VYEEADSVGS SVNNTKLVYG HRIDGVSFVR
310 320 330 340 350
YRRPLNDSDN KFDFPVNSTE SLTVIWALGV IKPPDVINPY YLPVNHGGVE
360 370 380 390 400
SENFGHFSLN LSDHVDECLG PLDADNKYDQ DVIIADAHAP LVVTAGPSVH
410 420 430 440 450
YPNPPNPSKV LYINKKEAPV LKVERGVPVK FSIEAGHDVS FYITSDFLGG
460 470 480 490 500
NASLRNRTET IYAGGQETHG VLSSPSELVW APNRNTPDQL YYHSIFQEKM
510 520 530 540 550
GWKVQVVDGG LSDMYNNSVN LDDQQVKFFW TIVGDSISIA ARGEKKSGYL
560 570 580 590 600
AIGFGSEMTN SYAYIGWFDR NGTGHVNTYW IDGESASAVH PTTENMTYVR
610 620 630 640 650
CKSEEGIITL EFTRPLKPSC SHRDRPECKN MIDPTTPLKV IWAMGAKWTD
660 670 680 690 700
GQLTERNMHS VTSQRPVRVM LTRGSAEADQ DLRPVLGVHG FMMFLAWGIL
710 720 730 740 750
LPGGILSARY LKHIKGDGWF KIHMYLQCSG LAIVFLGLLF AVAELNGFSF
760 770 780 790 800
SSTHVKFGFT AIVLACAQPV NAWLRPAKPA QGELISSKRL IWEYSHSIVG
810 820 830 840 850
QSAVVVGVVA LFTGMKHLGE RNGTENVDGL NLALGLWVFL CVVTVAYLEY
860 870 880 890 900
RERGRRRARN LSRGNWVLGN VEEDDSIDLI DSRGGFRDKD DEDRNGGRME

IQLEPLK
Length:907
Mass (Da):100,533
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F91E2660D56C4EA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB005232 Genomic DNA Translation: BAB08762.1
CP002688 Genomic DNA Translation: AED96545.1
AY090233 mRNA Translation: AAL90897.1
BT002628 mRNA Translation: AAO11544.1
AK227031 mRNA Translation: BAE99093.1

NCBI Reference Sequences

More...
RefSeqi
NP_200294.1, NM_124864.5

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G54830.1; AT5G54830.1; AT5G54830

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
835573

Gramene; a comparative resource for plants

More...
Gramenei
AT5G54830.1; AT5G54830.1; AT5G54830

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G54830

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005232 Genomic DNA Translation: BAB08762.1
CP002688 Genomic DNA Translation: AED96545.1
AY090233 mRNA Translation: AAL90897.1
BT002628 mRNA Translation: AAO11544.1
AK227031 mRNA Translation: BAE99093.1
RefSeqiNP_200294.1, NM_124864.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT5G54830.1

Proteomic databases

PaxDbiQ9FFU6
PRIDEiQ9FFU6
ProteomicsDBi241117

Genome annotation databases

EnsemblPlantsiAT5G54830.1; AT5G54830.1; AT5G54830
GeneIDi835573
GrameneiAT5G54830.1; AT5G54830.1; AT5G54830
KEGGiath:AT5G54830

Organism-specific databases

AraportiAT5G54830
TAIRilocus:2160220, AT5G54830

Phylogenomic databases

eggNOGiKOG4293, Eukaryota
KOG4731, Eukaryota
HOGENOMiCLU_340217_0_0_1
InParanoidiQ9FFU6
OMAiFYVSSVH
OrthoDBi599276at2759
PhylomeDBiQ9FFU6

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9FFU6

Gene expression databases

ExpressionAtlasiQ9FFU6, baseline and differential
GenevisibleiQ9FFU6, AT

Family and domain databases

InterProiView protein in InterPro
IPR006593, Cyt_b561/ferric_Rdtase_TM
IPR019545, DM13_domain
IPR005018, DOMON_domain
PfamiView protein in Pfam
PF03188, Cytochrom_B561, 1 hit
PF10517, DM13, 1 hit
PF03351, DOMON, 2 hits
SMARTiView protein in SMART
SM00665, B561, 1 hit
SM00686, DM13, 1 hit
SM00664, DoH, 2 hits
PROSITEiView protein in PROSITE
PS50939, CYTOCHROME_B561, 1 hit
PS51549, DM13, 1 hit
PS50836, DOMON, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB561A_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FFU6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 2014
Last sequence update: March 1, 2001
Last modified: August 12, 2020
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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