Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic

Gene

At5g41670

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase 3, chloroplastic (At1g24280), Glucose-6-phosphate 1-dehydrogenase 1, chloroplastic (APG1), Glucose-6-phosphate 1-dehydrogenase (At3g27300), Glucose-6-phosphate 1-dehydrogenase (AXX17_At3g29760), Glucose-6-phosphate 1-dehydrogenase (G6PD4), Glucose-6-phosphate 1-dehydrogenase 2, chloroplastic (At5g13110), Glucose-6-phosphate 1-dehydrogenase (AXX17_At1g25530), Glucose-6-phosphate 1-dehydrogenase (At5g35790), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g33080), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g33080), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g12520), Glucose-6-phosphate 1-dehydrogenase (G6PD5), Glucose-6-phosphate 1-dehydrogenase (G6PD5), Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 2 (ACG12), Glucose-6-phosphate 1-dehydrogenase (At1g09420), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g38480), Glucose-6-phosphate 1-dehydrogenase (AXX17_At1g09330), Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 1 (ACG9), Glucose-6-phosphate 1-dehydrogenase (At5g40760), Glucose-6-phosphate 1-dehydrogenase 4, chloroplastic (At1g09420)
  2. Probable 6-phosphogluconolactonase 5, chloroplastic (EMB2024), Probable 6-phosphogluconolactonase 3 (At5g24420), Probable 6-phosphogluconolactonase 4 (At5g24410), Probable 6-phosphogluconolactonase 1 (At1g13700), Probable 6-phosphogluconolactonase 2 (At3g49360)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At5g39410), 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At3g01580), 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic (At5g41670), 6-phosphogluconate dehydrogenase, decarboxylating 3 (At3g02360), 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic (At1g64190), 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At1g57660)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei108NADPBy similarity1
Binding sitei108SubstrateBy similarity1
Active sitei188Proton acceptorBy similarity1
Active sitei195Proton donorBy similarity1
Binding sitei196SubstrateBy similarity1
Binding sitei266Substrate; via amide nitrogenBy similarity1
Binding sitei293SubstrateBy similarity1
Binding sitei458Substrate; shared with dimeric partnerBy similarity1
Binding sitei464Substrate; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 18NADPBy similarity6
Nucleotide bindingi36 – 38NADPBy similarity3
Nucleotide bindingi80 – 82NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • D-gluconate metabolic process Source: UniProtKB-KW
  • pentose-phosphate shunt, oxidative branch Source: TAIR
  • response to cadmium ion Source: TAIR
  • response to fructose Source: TAIR
  • response to glucose Source: TAIR
  • response to sucrose Source: TAIR

Keywordsi

Molecular functionOxidoreductase
Biological processGluconate utilization, Pentose shunt
LigandNADP

Enzyme and pathway databases

BioCyciARA:AT5G41670-MONOMER
ReactomeiR-ATH-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00410

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic (EC:1.1.1.44)
Gene namesi
Ordered Locus Names:At5g41670
ORF Names:MBK23.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G41670
TAIRilocus:2160422 AT5G41670

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004210991 – 4876-phosphogluconate dehydrogenase, decarboxylating 2, chloroplasticAdd BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9FFR3
PRIDEiQ9FFR3
ProMEXiQ9FFR3

PTM databases

iPTMnetiQ9FFR3
SwissPalmiQ9FFR3

Expressioni

Gene expression databases

ExpressionAtlasiQ9FFR3 baseline and differential
GenevisibleiQ9FFR3 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi19420, 1 interactor
IntActiQ9FFR3, 1 interactor
STRINGi3702.AT5G41670.1

Structurei

3D structure databases

ProteinModelPortaliQ9FFR3
SMRiQ9FFR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni134 – 136Substrate bindingBy similarity3
Regioni191 – 192Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2653 Eukaryota
COG0362 LUCA
HOGENOMiHOG000255147
InParanoidiQ9FFR3
KOiK00033
OMAiFTAYNNV
OrthoDBiEOG09360AB8
PhylomeDBiQ9FFR3

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006114 6PGDH_C
IPR006113 6PGDH_Gnd/GntZ
IPR006115 6PGDH_NADP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR006183 Pgluconate_DH
PfamiView protein in Pfam
PF00393 6PGD, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000109 6PGD, 1 hit
PRINTSiPR00076 6PGDHDRGNASE
SMARTiView protein in SMART
SM01350 6PGD, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00873 gnd, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FFR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVALSRIG LAGLAVMGQN LALNIADKGF PISVYNRTTS KVDETLDRAS
60 70 80 90 100
NEGKLPVAGQ YSPRDFVLSI QRPRSVIILV KAGAPVDQTI SALSEYMEPG
110 120 130 140 150
DCIIDGGNEW YQNTERRIVE AEKKGLLYLG MGVSGGEEGA RNGPSLMPGG
160 170 180 190 200
SFTAYNNVKD ILEKVAAQVE DGPCVTYIGE GGSGNFVKMV HNGIEYGDMQ
210 220 230 240 250
LISEAYDVLK NVGGLSNDEL AEIFTEWNRG ELESFLVEIT SDIFRVKDDY
260 270 280 290 300
GDGELVDKIL DKTGMKGTGK WTVQQAAELS VAAPTIAASL DCRYLSGLKD
310 320 330 340 350
ERENAAKVLE EAGLKEDIGS ASRGVDKKRL IDDVRQALYA SKICSYAQGM
360 370 380 390 400
NLLRAKSLEK GWDLNLGEMA RIWKGGCIIR AVFLDRIKKA YQRNPNLASL
410 420 430 440 450
VVDPDFAKEM VQRQAAWRRV VGLAISAGIS TPGMCASLAY FDTYRRARLP
460 470 480
ANLVQAQRDL FGAHTYERTD RPGAYHTEWT KLARKSQ
Length:487
Mass (Da):53,318
Last modified:March 1, 2001 - v1
Checksum:iABB2D413CEA15CF2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40S → P in AAM61057 (Ref. 4) Curated1
Sequence conflicti91S → T in AAM61057 (Ref. 4) Curated1
Sequence conflicti395P → T in AAM61057 (Ref. 4) Curated1
Sequence conflicti454Missing in AAM61057 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005233 Genomic DNA Translation: BAB11473.1
CP002688 Genomic DNA Translation: AED94705.1
CP002688 Genomic DNA Translation: AED94706.1
CP002688 Genomic DNA Translation: ANM71118.1
CP002688 Genomic DNA Translation: ANM71119.1
AY125503 mRNA Translation: AAM78095.1
BT002261 mRNA Translation: AAN72272.1
AY084486 mRNA Translation: AAM61057.1
RefSeqiNP_001318724.1, NM_001344409.1
NP_001332670.1, NM_001344410.1
NP_198982.1, NM_123531.3
NP_851113.1, NM_180782.3
UniGeneiAt.23390

Genome annotation databases

EnsemblPlantsiAT5G41670.1; AT5G41670.1; AT5G41670
AT5G41670.2; AT5G41670.2; AT5G41670
AT5G41670.3; AT5G41670.3; AT5G41670
AT5G41670.4; AT5G41670.4; AT5G41670
GeneIDi834169
GrameneiAT5G41670.1; AT5G41670.1; AT5G41670
AT5G41670.2; AT5G41670.2; AT5G41670
AT5G41670.3; AT5G41670.3; AT5G41670
AT5G41670.4; AT5G41670.4; AT5G41670
KEGGiath:AT5G41670

Similar proteinsi

Entry informationi

Entry namei6PGD2_ARATH
AccessioniPrimary (citable) accession number: Q9FFR3
Secondary accession number(s): Q8LG34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health