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Entry version 103 (10 Feb 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Anaphase-promoting complex subunit 1

Gene

APC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation. Involved in the control of endoreduplication (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anaphase-promoting complex subunit 1
Alternative name(s):
Cyclosome subunit 1
Protein EMBRYO DEFECTIVE 2771
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APC1
Synonyms:EMB2771
Ordered Locus Names:At5g05560
ORF Names:MOP10.10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G05560

The Arabidopsis Information Resource

More...
TAIRi
locus:2169657, AT5G05560

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003968371 – 1678Anaphase-promoting complex subunit 1Add BLAST1678

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9FFF9

PRoteomics IDEntifications database

More...
PRIDEi
Q9FFF9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
246665

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9FFF9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9FFF9, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The APC/C is composed of at least 10 subunits.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
15718, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q9FFF9, 13 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT5G05560.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1089 – 1116PC 1Add BLAST28
Repeati1156 – 1194PC 2Add BLAST39
Repeati1256 – 1293PC 3Add BLAST38
Repeati1320 – 1354PC 4Add BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the APC1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1858, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001202_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9FFF9

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9FFF9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024990, Apc1

The PANTHER Classification System

More...
PANTHERi
PTHR12827, PTHR12827, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12859, ANAPC1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9FFF9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPGVRQLTV LGKFKPFGLI AEATDGKSPD DSYQYFLFDP ELTGERDDAD
60 70 80 90 100
GNDANFSRQR EHELFIRDNC NVRKGYALVE ANFIGYWYNA CWSNLGRGTE
110 120 130 140 150
AFLCVLQIAC LTIYNTSGEV VSVPLMRTVK SIWPLPCGLL LEQAGEVNPP
160 170 180 190 200
SHVPFSPVSP ILGSREMLRQ RKEVGNSSPQ NFHSPVAHDL ISKRDMPCMS
210 220 230 240 250
SHLILRDPLE EPGPTYVEER GKLTIMKDYD ERTIWTSDRL PLMTSYNKGK
260 270 280 290 300
MQHSVWAAEF IESNLEASAS CSSGIVPDAV LSKRVSFRRI WQAKGAKKAA
310 320 330 340 350
SKVFLATDNS VPVICFLILE QKKLLSVGLQ TVEINNEILF DVKPDISWSV
360 370 380 390 400
SAIAAAPVVV TRSQVKIGLL PHLDIIVLSP ENDLFLYSGK QCLCRYVLPS
410 420 430 440 450
WLGESIGSGD GESAKTDSGF RNLKITGLSD AVLGSINLSV NHSQIFRCAL
460 470 480 490 500
TGKPSSSLAN DCIAAIAEGL RSDLYSLFLS LLWGDGHSDL QGSSIHFEWE
510 520 530 540 550
ALCNIFLEIC QKPTVVHRKQ PKTASESSWE FLLISKFHKT YSRFHNGITS
560 570 580 590 600
INRLDLEGIV PFDSKICSEE TLGSSCELMV QSLDCLHAVY ESLKMDNLRK
610 620 630 640 650
QDLHHLAVLL CNIAKFLDEK CYLDYYIRDF PRLSTTIGAC TTLSSSRKPP
660 670 680 690 700
NLFRWLENCL RRGCLSTNFD DLPDLIRRDG CSIVSWARKV VSFYSVLFGD
710 720 730 740 750
KPEGRTLSSG VPCNIAPGSY SCNEELTILA MAGERFGLHQ LDLLPSGVSL
760 770 780 790 800
PLRHALDSCR ESPPADWPAI AYVLLGREDM ALSVFRNFSS SKEFEMQSNT
810 820 830 840 850
SLISMSIPYM LHLHPVIVPS SESIGLENTK IEDTNSVDGS VIDGMEHIFN
860 870 880 890 900
SYTQLRYGRD LRLNEVRRLL CSARPVVVQT AANPTISDQE QQQAFTVPKL
910 920 930 940 950
VLAGRLPSQQ NAIVNLDPNI RNIQELKTWP EFHNAVAAGL RLAPLQGKVS
960 970 980 990 1000
RTWIRYNKPG EPNAVHAGLL FGLGLQGYLH VLNLSDIYQY FTQDHESTTV
1010 1020 1030 1040 1050
GLMLGLAASY RGTMQPDIAK ALFFHVPARY QASYTEFEIP TLLQSAALVS
1060 1070 1080 1090 1100
VGMLFEGSAH QQTMQLLLGE IGRRSAGDNV LEREGYAVSA GFSLGLVALG
1110 1120 1130 1140 1150
RGGDALGSMD SLVNRLLLYL GAKEERSILV PSLEDHRSAA QITDGSTSNV
1160 1170 1180 1190 1200
DITAPGAIIA LTLMYLKTES EVIFSKLSIP QTHYDLECVR PDFIMLRVIA
1210 1220 1230 1240 1250
RNLIMWSRIC PTCDWIQSQV PEVVKNGISQ LRDDMDNMYE VDVEALVQAY
1260 1270 1280 1290 1300
VNIVAGACIS LGLRFAGTRD GNARDLLNSY ALYLLNEIKP LSATPGNAFP
1310 1320 1330 1340 1350
RGISKFVDRG TLEMCLYLII ISLSVVMAGS GDLQVFRLLR FLRSRNSADG
1360 1370 1380 1390 1400
HANYGTQMAV SLATGFLFLG GGMRTFSTNN GSLAMLLITL YPRLPSGPND
1410 1420 1430 1440 1450
NRCHLQAFRH LYVLATEARW LQTIDVDSGL PVYAPLEVTV KETKLYSETK
1460 1470 1480 1490 1500
FCEITPCILP ERAILKRICV CGPRYWPQQI ELVFGLRTLG ESNLIANSHR
1510 1520 1530 1540 1550
ELDSDSVDHL VSTFSSDPSL IAFAQLCCDK SWNNSFDFLI LDLILWSQVA
1560 1570 1580 1590 1600
LAYNEAVSTG RLASSGGFVQ SIFLASLRKR CEEVLNCSTE LKINLRNYLT
1610 1620 1630 1640 1650
SEAWPYDKNS KLQKDIIILS WYLKWFNVPS PSIIKAAVEK IKSKSKNSTS
1660 1670
AIPLLRLLLP NTHISVIGEI DRVFFPSN
Length:1,678
Mass (Da):186,276
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBBE887FCAE27CA3B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8BDT7A0A1P8BDT7_ARATH
Anaphase-promoting complex subunit ...
EMB2771 anaphase promoting complex 1, APC1, EMBRYO DEFECTIVE 2771, MOP10.10, MOP10_10
1,680Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2H1ZE59A0A2H1ZE59_ARATH
Anaphase-promoting complex subunit ...
EMB2771 anaphase promoting complex 1, APC1, EMBRYO DEFECTIVE 2771, MOP10.10, MOP10_10
1,711Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1P8BDT3A0A1P8BDT3_ARATH
Anaphase-promoting complex subunit ...
EMB2771 anaphase promoting complex 1, APC1, EMBRYO DEFECTIVE 2771, MOP10.10, MOP10_10
1,807Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB005241 Genomic DNA Translation: BAB11545.1
CP002688 Genomic DNA No translation available.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005241 Genomic DNA Translation: BAB11545.1
CP002688 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi15718, 13 interactors
IntActiQ9FFF9, 13 interactors
STRINGi3702.AT5G05560.1

Proteomic databases

PaxDbiQ9FFF9
PRIDEiQ9FFF9
ProteomicsDBi246665

Organism-specific databases

AraportiAT5G05560
TAIRilocus:2169657, AT5G05560

Phylogenomic databases

eggNOGiKOG1858, Eukaryota
HOGENOMiCLU_001202_1_0_1
InParanoidiQ9FFF9
PhylomeDBiQ9FFF9

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9FFF9

Gene expression databases

ExpressionAtlasiQ9FFF9, baseline and differential
GenevisibleiQ9FFF9, AT

Family and domain databases

InterProiView protein in InterPro
IPR024990, Apc1
PANTHERiPTHR12827, PTHR12827, 3 hits
PfamiView protein in Pfam
PF12859, ANAPC1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPC1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FFF9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: March 1, 2001
Last modified: February 10, 2021
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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