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Entry version 141 (12 Aug 2020)
Sequence version 1 (01 Mar 2001)
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Protein

BTB/POZ domain and ankyrin repeat-containing protein NPR1

Gene

NPR1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key positive factor of disease resistance. Plays an essential role in benzothiadiazole (BTH)-induced resistance to the blast fungus disease caused by Magnaporthe oryzae (PubMed:20924648). Involved in defense response against the bacterial blight disease caused by Xanthomonas oryzae pv. oryzae (Xoo). Over-expression of NPR1/NH1 confers disease resistance to Xoo, but also enhances herbivore susceptibility (PubMed:17309686). Functions as a transcriptional coactivator of TGA2.1 and LG2 in vitro (PubMed:22353606). Involved in defense response against herbivore. Plants silencing NPR1/NH1 have increased herbivore-induced trypsin proteinase inhibitors and volatiles, which reduces the performance of the striped stem borer (SSB) Chilo suppressalis (PubMed:22694163).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPlant defense

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes for plant species

More...
PlantReactomei
R-OSA-6788019, Salicylic acid signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BTB/POZ domain and ankyrin repeat-containing protein NPR1Curated
Short name:
OsNPR11 Publication
Alternative name(s):
NPR1 homolog 1Curated
Short name:
OsNH1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NPR11 Publication
Synonyms:NH1Curated
Ordered Locus Names:Os01g0194300Imported, LOC_Os01g09800Curated
ORF Names:P0001B06.13Imported, P0671B11.44Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryza sativa subsp. japonica (Rice)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39947 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000059680 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1
  • UP000000763 Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi76C → A: Nuclear localization; when associated with A-216. 1 Publication1
Mutagenesisi216C → A: Nuclear localization; when associated with A-76. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004370001 – 582BTB/POZ domain and ankyrin repeat-containing protein NPR1Add BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi76Interchain (with C-216); in linked formBy similarity
Disulfide bondi216Interchain (with C-76); in linked formBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9FDY4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By mechanical wounding, treatment with jasmonic acid (JA), salicylic acid (SA) and benzothiadiazole (BTH), and in response to infestation by the rice striped stem borer Chilo suppressalis and rice leaf folder Cnaphalocrocis medinalis.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomer in an uninduced state; disulfide-linked.

Forms activated monomer upon changes in cellular redox potential (PubMed:17309686).

Interacts with TGA2.1, TGA2.2, TGA2.3, LG2, TGAL1 and TGAL4 (PubMed:24919709).

Interacts with NRR, RH1, RH2 and RH3 (PubMed:22353606, PubMed:24919709).

3 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4530.OS01T0194300-01

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9FDY4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 140BTBPROSITE-ProRule annotationAdd BLAST86
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati269 – 299ANK 1Sequence analysisAdd BLAST31
Repeati301 – 328ANK 2Sequence analysisAdd BLAST28
Repeati332 – 361ANK 3Sequence analysisAdd BLAST30

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034895_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9FDY4

KEGG Orthology (KO)

More...
KOi
K14508

Identification of Orthologs from Complete Genome Data

More...
OMAi
VAFMAQV

Database of Orthologous Groups

More...
OrthoDBi
342053at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR000210, BTB/POZ_dom
IPR021094, NPR1/NIM1-like_C
IPR024228, NPR_central_dom
IPR011333, SKP1/BTB/POZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651, BTB, 1 hit
PF11900, DUF3420, 1 hit
PF12313, NPR1_like_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 3 hits
SM00225, BTB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF54695, SSF54695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS50097, BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9FDY4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPPTSHVTN AFSDSDSASV EEGGADADAD VEALRRLSDN LAAAFRSPED
60 70 80 90 100
FAFLADARIA VPGGGGGGGD LLVHRCVLSA RSPFLRGVFA RRAAAAAGGG
110 120 130 140 150
GEDGGERLEL RELLGGGGEE VEVGYEALRL VLDYLYSGRV GDLPKAACLC
160 170 180 190 200
VDEDCAHVGC HPAVAFMAQV LFAASTFQVA ELTNLFQRRL LDVLDKVEVD
210 220 230 240 250
NLLLILSVAN LCNKSCMKLL ERCLDMVVRS NLDMITLEKS LPPDVIKQII
260 270 280 290 300
DARLSLGLIS PENKGFPNKH VRRIHRALDS DDVELVRMLL TEGQTNLDDA
310 320 330 340 350
FALHYAVEHC DSKITTELLD LALADVNHRN PRGYTVLHIA ARRREPKIIV
360 370 380 390 400
SLLTKGARPA DVTFDGRKAV QISKRLTKQG DYFGVTEEGK PSPKDRLCIE
410 420 430 440 450
ILEQAERRDP QLGEASVSLA MAGESLRGRL LYLENRVALA RIMFPMEARV
460 470 480 490 500
AMDIAQVDGT LEFNLGSGAN PPPERQRTTV DLNESPFIMK EEHLARMTAL
510 520 530 540 550
SKTVELGKRF FPRCSNVLDK IMDDETDPVS LGRDTSAEKR KRFHDLQDVL
560 570 580
QKAFHEDKEE NDRSGLSSSS SSTSIGAIRP RR
Length:582
Mass (Da):63,766
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBAED95839E6E76A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti112E → G in AAP92751 (Ref. 2) Curated1
Sequence conflicti269K → N in AAP92751 (Ref. 2) Curated1
Sequence conflicti313K → Q in AAP92751 (Ref. 2) Curated1
Sequence conflicti369A → G in AAP92751 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ450947 mRNA Translation: ABE11613.1
DQ450948 Genomic DNA Translation: ABE11614.1
AY323485 mRNA Translation: AAP92751.1
HM991169 mRNA Translation: AEF30412.1
AP002537 Genomic DNA Translation: BAB16860.1
AP002746 Genomic DNA Translation: BAB12719.1
AP008207 Genomic DNA Translation: BAF04200.1
AP014957 Genomic DNA Translation: BAS70853.1
AK120715 mRNA Translation: BAH00140.1

NCBI Reference Sequences

More...
RefSeqi
XP_015622114.1, XM_015766628.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
Os01t0194300-01; Os01t0194300-01; Os01g0194300

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4327315

Gramene; a comparative resource for plants

More...
Gramenei
Os01t0194300-01; Os01t0194300-01; Os01g0194300

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
osa:4327315

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ450947 mRNA Translation: ABE11613.1
DQ450948 Genomic DNA Translation: ABE11614.1
AY323485 mRNA Translation: AAP92751.1
HM991169 mRNA Translation: AEF30412.1
AP002537 Genomic DNA Translation: BAB16860.1
AP002746 Genomic DNA Translation: BAB12719.1
AP008207 Genomic DNA Translation: BAF04200.1
AP014957 Genomic DNA Translation: BAS70853.1
AK120715 mRNA Translation: BAH00140.1
RefSeqiXP_015622114.1, XM_015766628.1

3D structure databases

SMRiQ9FDY4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4530.OS01T0194300-01

Proteomic databases

PaxDbiQ9FDY4

Genome annotation databases

EnsemblPlantsiOs01t0194300-01; Os01t0194300-01; Os01g0194300
GeneIDi4327315
GrameneiOs01t0194300-01; Os01t0194300-01; Os01g0194300
KEGGiosa:4327315

Phylogenomic databases

eggNOGiKOG0504, Eukaryota
HOGENOMiCLU_034895_1_0_1
InParanoidiQ9FDY4
KOiK14508
OMAiVAFMAQV
OrthoDBi342053at2759

Enzyme and pathway databases

PlantReactomeiR-OSA-6788019, Salicylic acid signaling

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR000210, BTB/POZ_dom
IPR021094, NPR1/NIM1-like_C
IPR024228, NPR_central_dom
IPR011333, SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF00651, BTB, 1 hit
PF11900, DUF3420, 1 hit
PF12313, NPR1_like_C, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 3 hits
SM00225, BTB, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF54695, SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS50097, BTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNPR1_ORYSJ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FDY4
Secondary accession number(s): Q7XBH3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 7, 2016
Last sequence update: March 1, 2001
Last modified: August 12, 2020
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
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