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Protein

Nitric oxide reductase

Gene

fprA

Organism
Moorella thermoacetica (strain ATCC 39073 / JCM 9320)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has nitric oxide reductase activity in combination with Hrb; probably involved in nitrosative stress protection.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi81Iron 1By similarity1
Metal bindingi83Iron 1By similarity1
Metal bindingi85Iron 2By similarity1
Metal bindingi148Iron 1By similarity1
Metal bindingi167Iron 1By similarity1
Metal bindingi167Iron 2By similarity1
Metal bindingi228Iron 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
LigandFlavoprotein, FMN, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMTHE264732:G1G5J-1340-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nitric oxide reductase (EC:1.-.-.-)
Alternative name(s):
FMN protein FprA
Flavoprotein A
Type A flavoprotein FprA
Gene namesi
Name:fprA
Ordered Locus Names:Moth_1287
OrganismiMoorella thermoacetica (strain ATCC 39073 / JCM 9320)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
Proteomesi
  • UP000007053 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

DrugBankiDB03247 Riboflavin Monophosphate

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002168051 – 399Nitric oxide reductaseAdd BLAST399

Expressioni

Inductioni

Constitutively expressed.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi264732.Moth_1287

Structurei

Secondary structure

1399
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 8Combined sources4
Beta strandi11 – 13Combined sources3
Beta strandi16 – 20Combined sources5
Turni25 – 28Combined sources4
Beta strandi35 – 37Combined sources3
Beta strandi40 – 42Combined sources3
Beta strandi44 – 46Combined sources3
Beta strandi48 – 50Combined sources3
Helixi55 – 57Combined sources3
Helixi58 – 68Combined sources11
Beta strandi75 – 78Combined sources4
Helixi84 – 87Combined sources4
Helixi90 – 96Combined sources7
Beta strandi101 – 104Combined sources4
Helixi106 – 115Combined sources10
Beta strandi122 – 125Combined sources4
Beta strandi131 – 133Combined sources3
Beta strandi138 – 143Combined sources6
Beta strandi147 – 149Combined sources3
Beta strandi153 – 157Combined sources5
Turni158 – 161Combined sources4
Beta strandi162 – 166Combined sources5
Turni167 – 169Combined sources3
Helixi180 – 182Combined sources3
Helixi185 – 199Combined sources15
Helixi201 – 203Combined sources3
Helixi204 – 216Combined sources13
Beta strandi222 – 229Combined sources8
Helixi236 – 248Combined sources13
Beta strandi253 – 259Combined sources7
Beta strandi262 – 264Combined sources3
Helixi265 – 279Combined sources15
Beta strandi283 – 288Combined sources6
Helixi289 – 291Combined sources3
Helixi294 – 303Combined sources10
Beta strandi305 – 310Combined sources6
Helixi320 – 322Combined sources3
Helixi323 – 332Combined sources10
Beta strandi338 – 348Combined sources11
Helixi351 – 361Combined sources11
Beta strandi365 – 367Combined sources3
Beta strandi373 – 377Combined sources5
Helixi380 – 397Combined sources18

3D structure databases

ProteinModelPortaliQ9FDN7
SMRiQ9FDN7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9FDN7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 394Flavodoxin-likePROSITE-ProRule annotationAdd BLAST140

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 221Zinc metallo-hydrolaseAdd BLAST190

Sequence similaritiesi

In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.Curated

Phylogenomic databases

eggNOGiENOG4105CNW Bacteria
COG0426 LUCA
HOGENOMiHOG000224528
OrthoDBiPOG091H01XB

Family and domain databases

Gene3Di3.40.50.360, 1 hit
3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR008254 Flavodoxin/NO_synth
IPR029039 Flavoprotein-like_sf
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR016440 Rubredoxin-O_OxRdtase
PfamiView protein in Pfam
PF00258 Flavodoxin_1, 1 hit
PF00753 Lactamase_B, 1 hit
PIRSFiPIRSF005243 ROO, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF52218 SSF52218, 1 hit
SSF56281 SSF56281, 1 hit
PROSITEiView protein in PROSITE
PS50902 FLAVODOXIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9FDN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQPVAITDG IYWVGAVDWN IRYFHGPAFS THRGTTYNAY LIVDDKTALV
60 70 80 90 100
DTVYEPFKEE LIAKLKQIKD PVKLDYLVVN HTESDHAGAF PAIMELCPDA
110 120 130 140 150
HVLCTQRAFD SLKAHYSHID FNYTIVKTGT SVSLGKRSLT FIEAPMLHWP
160 170 180 190 200
DSMFTYVPEE ALLLPNDAFG QHIATSVRFD DQVDAGLIMD EAAKYYANIL
210 220 230 240 250
MPFSNLITKK LDEIQKINLA IKTIAPSHGI IWRKDPGRII EAYARWAEGQ
260 270 280 290 300
GKAKAVIAYD TMWLSTEKMA HALMDGLVAG GCEVKLFKLS VSDRNDVIKE
310 320 330 340 350
ILDARAVLVG SPTINNDILP VVSPLLDDLV GLRPKNKVGL AFGAYGWGGG
360 370 380 390
AQKILEERLK AAKIELIAEP GPTVQWVPRG EDLQRCYELG RKIAARIAD
Length:399
Mass (Da):44,297
Last modified:March 1, 2001 - v1
Checksum:i198C380C41C58614
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202316 Genomic DNA Translation: AAG00802.1
CP000232 Genomic DNA Translation: ABC19601.1
RefSeqiWP_011392801.1, NC_007644.1
YP_430144.1, NC_007644.1

Genome annotation databases

EnsemblBacteriaiABC19601; ABC19601; Moth_1287
GeneIDi3831550
KEGGimta:Moth_1287
PATRICifig|264732.11.peg.1381

Similar proteinsi

Entry informationi

Entry nameiFPRA_MOOTA
AccessioniPrimary (citable) accession number: Q9FDN7
Secondary accession number(s): Q2RIY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2001
Last modified: February 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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