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Entry version 116 (10 Feb 2021)
Sequence version 1 (01 Mar 2001)
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Protein
Submitted name:

Non-ribosomal peptide synthetase

Gene

vibF

Organism
Vibrio cholerae
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:VC1579-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Non-ribosomal peptide synthetaseImported
Submitted name:
Six-domain nonribosomal peptide synthetaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vibFImported
ORF Names:C9J66_16975Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVibrio choleraeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri666 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248087 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1891O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1856 – 1931CarrierInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1399 – 1419DisorderedSequence analysisAdd BLAST21

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
3.30.559.10, 4 hits
3.40.50.12780, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 1 hit
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 4 hits
PF00550, PP-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 1 hit
PS50075, CARRIER, 1 hit
PS00012, PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9FDB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEMTAMQAA YWLGRQHDCL LDGVAAHLYA EFDGQALNRQ ALTEAVRALY
60 70 80 90 100
AKHPMLRLAI TKDGQQKILP LSTFHQLKVD DLSQWKPDEV ESFVHTKRQR
110 120 130 140 150
MTHQMLDLTQ GNPIEISLTL LPEGKHRLHI DADMIACDAQ SFRLLVDDLT
160 170 180 190 200
SLYLEAIEHR LEIIESDVVT FFQYLDAQQA DRALAKRKEV DKKWWQERLA
210 220 230 240 250
TIPAEPSLPY QPVPTDAVSA NSQRFAHWFT PVERKGLAEV ARQHHLTLTQ
260 270 280 290 300
LTLALFSQVI ANACQERQFR LNVPTFHRGN RSLDIEHTIG DFSNLLIFSA
310 320 330 340 350
DVGTTQTLLS LCQQTANQLH QLLRHESYSG VSVMRDLSRK QGGVQRSPIV
360 370 380 390 400
FTSGMEMRDE EIFSDHVTQH LGRMNWVISQ GAQVTLDAQI APAYEGILLN
410 420 430 440 450
WDVRMENFAD KDITALFAHY VDLIRCVALH PEMMQQSVQQ IDAQLGYARR
460 470 480 490 500
ESIQEMPLTP LQQAYLLGRS TQIALGGVAM HEFREYRGHI DTQSLHSRLL
510 520 530 540 550
YLVEHIPALR TRIDQEKWIQ WVSPCIALNW QAIDLQHLSR EQALLAVEPV
560 570 580 590 600
RQQYQQRMHD LTRSPWQICV VQLPIEEQEE FSSIVLTSFD ALIVDGRTHA
610 620 630 640 650
LILAALLGSE EPDITQVVQN ARDTQSISPQ FASKKAQDEA YWKSKLHPDC
660 670 680 690 700
PPPALPWKQA LETITTSRYA RESLQIPKES VGKLNRCGIE NGLFLNSLLT
710 720 730 740 750
ATILDVLSYW TTEIGMRVGF PVLIPSSNAI DGNESSFVIL EHEKSTLSLL
760 770 780 790 800
SQASKLQREM LEALEHLAFS GVDLNRLLMN QAPQALVLPV VLTNGLSWKT
810 820 830 840 850
LNPEDAVTLF DGVTQTPQVA LDIRLTYDEQ KNLIISFDYA LAVLETELIR
860 870 880 890 900
EMLSALHHRL SQITSSASLA APLEPCIDLS HYRFNSDESA SHDCDFLAKL
910 920 930 940 950
AQQLFVRTED KTAVICGEQT LSYAQLGEQV QRVMWQLKAR GLTTGNVLAI
960 970 980 990 1000
CLPRSVEHIV ISLASALSGI IWVPIDAASP KERLNYLLEN CHADLVVMDK
1010 1020 1030 1040 1050
PCEFGNVIAF DALIEPVLFA DGVPDVTPLD QLSRLSQSQQ TAYYLYTSGT
1060 1070 1080 1090 1100
TGKPKCVVVN NQATSNVIGQ TGQAWHLTSE DVVMSVTPLH HDMSVFDLFA
1110 1120 1130 1140 1150
TLSFGATLVL PAGHEEKDAL QWNRLIERHQ VTIWVSVPAI LEMLLSCTQA
1160 1170 1180 1190 1200
GQLHSLRLIA QGGDYIKPAT IAQLRAGSNP PRLISLGGPT ETTIWSIWHE
1210 1220 1230 1240 1250
LTADDVSVIP YGRPLAGNRY FIMDEIQRHV PQGVVGRIFT SGVNLAQGYL
1260 1270 1280 1290 1300
EDGELKQTDF VTVLDEHGHP VRAFRTGDQG YYRADGNIIF ASRINGYVKV
1310 1320 1330 1340 1350
RGVRVSLPDI EKQLQTHPAL ASVVVVDYAD TNGDTALAAL FSVKPQQSAS
1360 1370 1380 1390 1400
SQALREFAKQ SLPSSHIPSR FIALEALPLS ANGKVDRKQC QAHVQRQSIS
1410 1420 1430 1440 1450
VEPVGQPNQS QPLSPPTLSS ASLSEFEQRV WRQHQRHGDG RNQYATAYRL
1460 1470 1480 1490 1500
SGKVNIARLI TALSQLPNHF PVLNRRYVLD EASGLTLYSA KPTPLEIHFE
1510 1520 1530 1540 1550
HVESMDEAFE HLVRWQNQPM DLAKQATLSF CLLSLGSEER VLGVISHQII
1560 1570 1580 1590 1600
SEQWDWRRVF ECVTNGYNQI ACDIDPVMEG EDLSLGFTPV MPQTPLSQAL
1610 1620 1630 1640 1650
LPWLQPASHA TWIEQSLPSA NSAINTLCSR KYRIALHSSV LAEHGLAQPD
1660 1670 1680 1690 1700
KQEVLALIAA LFARYLAASA KLGQFELYVP HDVERKTREL NGSMIESQLV
1710 1720 1730 1740 1750
HIALKGFERP LSQLSQEILD AMRQPLTGGV ASETHASAAA LVTWLVDPSV
1760 1770 1780 1790 1800
HLQLEGLRCE KLLFAAMHPK FEVALGVGLN CQGALVLELA LDATVSPHVG
1810 1820 1830 1840 1850
AYLLEQFVAA IGGRTMPSST TSSSHVSAIE LTSNNPPTSN NAHAALAESE
1860 1870 1880 1890 1900
LELSAVNSSA VEECILAEFR SALGVAEMTA EDDFFDFGGH SLIATRVIGR
1910 1920 1930 1940 1950
LLSEQGIELH INDMFSFPNA KQLAQQAVLH RKPTSTSFAV SEVVESSKAP
1960 1970 1980 1990 2000
LSLAQASLWK AMSKYAKFGL THIFNLPFAL KFLDEVNEQA FGEAFHWLLL
2010 2020 2030 2040 2050
RHAGLRTHFG LEDGQPYQHV IAASNIEHYQ WFWTSKDNAA QSVARLLAQE
2060 2070 2080 2090 2100
AEHTFDLSQE LPLRLNFVRD EQTGTQYLSL LFHHIVLDEW SINILMDELA
2110 2120 2130 2140 2150
QVYQHSVQGT RPQWQTEPLP FHEFARKQRS SAFNQTHLNY WLTKFAGVPW
2160 2170 2180 2190 2200
AQPLFAADHP LSNSTGVDLG EGGWVEIKLP KSTMVSLYQL AKARHASLFN
2210 2220 2230 2240 2250
VMYAAISASV HCLGAPEKLL VGTPASGRLD AEFFDTVGYF TTMGVQLVDF
2260 2270 2280 2290 2300
TKVQTVWQLI EQVKNSINQS MPYTDIPIDL IEEGLKGVEH ETEGHMFEVF
2310 2320 2330 2340 2350
IQLHAKNKLH GELLLTEGHA IRFQQVDPDK SESGLGLQFE ILEERIEQKQ
2360 2370 2380 2390 2400
TLRVMMSYMS KHYSPAQVAL LTKVTSGMFE RFSDCIAQDI ALPTLKKQVR
2410
QLEDEACRSP SMG
Length:2,413
Mass (Da):269,519
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i761DACD0C4464E8F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF287255 Genomic DNA Translation: AAG00566.1
PYRF01000022 Genomic DNA Translation: PYC78681.1

NCBI Reference Sequences

More...
RefSeqi
WP_001923521.1, NZ_WNZU01000002.1

Genome annotation databases

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|666.1971.peg.1503

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287255 Genomic DNA Translation: AAG00566.1
PYRF01000022 Genomic DNA Translation: PYC78681.1
RefSeqiWP_001923521.1, NZ_WNZU01000002.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

PATRICifig|666.1971.peg.1503

Enzyme and pathway databases

BioCyciMetaCyc:VC1579-MONOMER

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.30.559.10, 4 hits
3.40.50.12780, 1 hit
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 1 hit
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 4 hits
PF00550, PP-binding, 1 hit
SMARTiView protein in SMART
SM00823, PKS_PP, 1 hit
SUPFAMiSSF47336, SSF47336, 1 hit
TIGRFAMsiTIGR01733, AA-adenyl-dom, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 1 hit
PS50075, CARRIER, 1 hit
PS00012, PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9FDB0_VIBCL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FDB0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: February 10, 2021
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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