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UniProtKB - Q9FDB0 (Q9FDB0_VIBCL)

Entry version 117 (07 Apr 2021)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
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Protein
Submitted name:

Non-ribosomal peptide synthetase

Gene

vibF

Organism
Vibrio cholerae
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:VC1579-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Non-ribosomal peptide synthetaseImported
Submitted name:
Six-domain nonribosomal peptide synthetaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vibFImported
ORF Names:C9J66_16975Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVibrio choleraeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri666 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248087 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1891O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9FDB0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1856 – 1931CarrierInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1399 – 1419DisorderedSequence analysisAdd BLAST21

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1200.10, 1 hit
3.30.559.10, 4 hits
3.40.50.12780, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00501, AMP-binding, 1 hit
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 4 hits
PF00550, PP-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00823, PKS_PP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47336, SSF47336, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01733, AA-adenyl-dom, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00455, AMP_BINDING, 1 hit
PS50075, CARRIER, 1 hit
PS00012, PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9FDB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEMTAMQAA YWLGRQHDCL LDGVAAHLYA EFDGQALNRQ ALTEAVRALY 
        60         70         80         90        100
AKHPMLRLAI TKDGQQKILP LSTFHQLKVD DLSQWKPDEV ESFVHTKRQR 
       110        120        130        140        150
MTHQMLDLTQ GNPIEISLTL LPEGKHRLHI DADMIACDAQ SFRLLVDDLT 
       160        170        180        190        200
SLYLEAIEHR LEIIESDVVT FFQYLDAQQA DRALAKRKEV DKKWWQERLA 
       210        220        230        240        250
TIPAEPSLPY QPVPTDAVSA NSQRFAHWFT PVERKGLAEV ARQHHLTLTQ 
       260        270        280        290        300
LTLALFSQVI ANACQERQFR LNVPTFHRGN RSLDIEHTIG DFSNLLIFSA 
       310        320        330        340        350
DVGTTQTLLS LCQQTANQLH QLLRHESYSG VSVMRDLSRK QGGVQRSPIV 
       360        370        380        390        400
FTSGMEMRDE EIFSDHVTQH LGRMNWVISQ GAQVTLDAQI APAYEGILLN 
       410        420        430        440        450
WDVRMENFAD KDITALFAHY VDLIRCVALH PEMMQQSVQQ IDAQLGYARR 
       460        470        480        490        500
ESIQEMPLTP LQQAYLLGRS TQIALGGVAM HEFREYRGHI DTQSLHSRLL 
       510        520        530        540        550
YLVEHIPALR TRIDQEKWIQ WVSPCIALNW QAIDLQHLSR EQALLAVEPV 
       560        570        580        590        600
RQQYQQRMHD LTRSPWQICV VQLPIEEQEE FSSIVLTSFD ALIVDGRTHA 
       610        620        630        640        650
LILAALLGSE EPDITQVVQN ARDTQSISPQ FASKKAQDEA YWKSKLHPDC 
       660        670        680        690        700
PPPALPWKQA LETITTSRYA RESLQIPKES VGKLNRCGIE NGLFLNSLLT 
       710        720        730        740        750
ATILDVLSYW TTEIGMRVGF PVLIPSSNAI DGNESSFVIL EHEKSTLSLL 
       760        770        780        790        800
SQASKLQREM LEALEHLAFS GVDLNRLLMN QAPQALVLPV VLTNGLSWKT 
       810        820        830        840        850
LNPEDAVTLF DGVTQTPQVA LDIRLTYDEQ KNLIISFDYA LAVLETELIR 
       860        870        880        890        900
EMLSALHHRL SQITSSASLA APLEPCIDLS HYRFNSDESA SHDCDFLAKL 
       910        920        930        940        950
AQQLFVRTED KTAVICGEQT LSYAQLGEQV QRVMWQLKAR GLTTGNVLAI 
       960        970        980        990       1000
CLPRSVEHIV ISLASALSGI IWVPIDAASP KERLNYLLEN CHADLVVMDK 
      1010       1020       1030       1040       1050
PCEFGNVIAF DALIEPVLFA DGVPDVTPLD QLSRLSQSQQ TAYYLYTSGT 
      1060       1070       1080       1090       1100
TGKPKCVVVN NQATSNVIGQ TGQAWHLTSE DVVMSVTPLH HDMSVFDLFA 
      1110       1120       1130       1140       1150
TLSFGATLVL PAGHEEKDAL QWNRLIERHQ VTIWVSVPAI LEMLLSCTQA 
      1160       1170       1180       1190       1200
GQLHSLRLIA QGGDYIKPAT IAQLRAGSNP PRLISLGGPT ETTIWSIWHE 
      1210       1220       1230       1240       1250
LTADDVSVIP YGRPLAGNRY FIMDEIQRHV PQGVVGRIFT SGVNLAQGYL 
      1260       1270       1280       1290       1300
EDGELKQTDF VTVLDEHGHP VRAFRTGDQG YYRADGNIIF ASRINGYVKV 
      1310       1320       1330       1340       1350
RGVRVSLPDI EKQLQTHPAL ASVVVVDYAD TNGDTALAAL FSVKPQQSAS 
      1360       1370       1380       1390       1400
SQALREFAKQ SLPSSHIPSR FIALEALPLS ANGKVDRKQC QAHVQRQSIS 
      1410       1420       1430       1440       1450
VEPVGQPNQS QPLSPPTLSS ASLSEFEQRV WRQHQRHGDG RNQYATAYRL 
      1460       1470       1480       1490       1500
SGKVNIARLI TALSQLPNHF PVLNRRYVLD EASGLTLYSA KPTPLEIHFE 
      1510       1520       1530       1540       1550
HVESMDEAFE HLVRWQNQPM DLAKQATLSF CLLSLGSEER VLGVISHQII 
      1560       1570       1580       1590       1600
SEQWDWRRVF ECVTNGYNQI ACDIDPVMEG EDLSLGFTPV MPQTPLSQAL 
      1610       1620       1630       1640       1650
LPWLQPASHA TWIEQSLPSA NSAINTLCSR KYRIALHSSV LAEHGLAQPD 
      1660       1670       1680       1690       1700
KQEVLALIAA LFARYLAASA KLGQFELYVP HDVERKTREL NGSMIESQLV 
      1710       1720       1730       1740       1750
HIALKGFERP LSQLSQEILD AMRQPLTGGV ASETHASAAA LVTWLVDPSV 
      1760       1770       1780       1790       1800
HLQLEGLRCE KLLFAAMHPK FEVALGVGLN CQGALVLELA LDATVSPHVG 
      1810       1820       1830       1840       1850
AYLLEQFVAA IGGRTMPSST TSSSHVSAIE LTSNNPPTSN NAHAALAESE 
      1860       1870       1880       1890       1900
LELSAVNSSA VEECILAEFR SALGVAEMTA EDDFFDFGGH SLIATRVIGR 
      1910       1920       1930       1940       1950
LLSEQGIELH INDMFSFPNA KQLAQQAVLH RKPTSTSFAV SEVVESSKAP 
      1960       1970       1980       1990       2000
LSLAQASLWK AMSKYAKFGL THIFNLPFAL KFLDEVNEQA FGEAFHWLLL 
      2010       2020       2030       2040       2050
RHAGLRTHFG LEDGQPYQHV IAASNIEHYQ WFWTSKDNAA QSVARLLAQE 
      2060       2070       2080       2090       2100
AEHTFDLSQE LPLRLNFVRD EQTGTQYLSL LFHHIVLDEW SINILMDELA 
      2110       2120       2130       2140       2150
QVYQHSVQGT RPQWQTEPLP FHEFARKQRS SAFNQTHLNY WLTKFAGVPW 
      2160       2170       2180       2190       2200
AQPLFAADHP LSNSTGVDLG EGGWVEIKLP KSTMVSLYQL AKARHASLFN 
      2210       2220       2230       2240       2250
VMYAAISASV HCLGAPEKLL VGTPASGRLD AEFFDTVGYF TTMGVQLVDF 
      2260       2270       2280       2290       2300
TKVQTVWQLI EQVKNSINQS MPYTDIPIDL IEEGLKGVEH ETEGHMFEVF 
      2310       2320       2330       2340       2350
IQLHAKNKLH GELLLTEGHA IRFQQVDPDK SESGLGLQFE ILEERIEQKQ 
      2360       2370       2380       2390       2400
TLRVMMSYMS KHYSPAQVAL LTKVTSGMFE RFSDCIAQDI ALPTLKKQVR 
      2410 
QLEDEACRSP SMG
Length:2,413
Mass (Da):269,519
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i761DACD0C4464E8F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF287255 Genomic DNA Translation: AAG00566.1
PYRF01000022 Genomic DNA Translation: PYC78681.1

NCBI Reference Sequences

More...RefSeqi		WP_001923521.1, NZ_WNZU01000002.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		PYC78681; PYC78681; C9J66_16975

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|666.1971.peg.1503

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287255 Genomic DNA Translation: AAG00566.1
PYRF01000022 Genomic DNA Translation: PYC78681.1
RefSeqiWP_001923521.1, NZ_WNZU01000002.1

3D structure databases

SMRiQ9FDB0
ModBaseiSearch...

Genome annotation databases

EnsemblBacteriaiPYC78681; PYC78681; C9J66_16975
PATRICifig|666.1971.peg.1503

Enzyme and pathway databases

BioCyciMetaCyc:VC1579-MONOMER

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.30.559.10, 4 hits
3.40.50.12780, 1 hit
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 1 hit
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 4 hits
PF00550, PP-binding, 1 hit
SMARTiView protein in SMART
SM00823, PKS_PP, 1 hit
SUPFAMiSSF47336, SSF47336, 1 hit
TIGRFAMsiTIGR01733, AA-adenyl-dom, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 1 hit
PS50075, CARRIER, 1 hit
PS00012, PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9FDB0_VIBCL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9FDB0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: April 7, 2021
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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