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Entry version 130 (02 Jun 2021)
Sequence version 4 (23 Jan 2007)
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Protein

Carbon monoxide dehydrogenase 2

Gene

cooS2

Organism
Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inactivated by O2.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi39Iron-sulfur 1 (4Fe-4S); shared with dimeric partner1 Publication1
Metal bindingi47Iron-sulfur 1 (4Fe-4S); shared with dimeric partner1 Publication1
Metal bindingi48Iron-sulfur 2 (4Fe-4S)1 Publication1
Metal bindingi51Iron-sulfur 2 (4Fe-4S)1 Publication1
Metal bindingi56Iron-sulfur 2 (4Fe-4S)1 Publication1
Metal bindingi70Iron-sulfur 2 (4Fe-4S)1 Publication1
Metal bindingi261Nickel-iron-sulfur (Ni-4Fe-5S); via tele nitrogen3 Publications1
Metal bindingi295Nickel-iron-sulfur (Ni-4Fe-5S)3 Publications1
Metal bindingi333Nickel-iron-sulfur (Ni-4Fe-5S)3 Publications1
Metal bindingi446Nickel-iron-sulfur (Ni-4Fe-5S)3 Publications1
Metal bindingi476Nickel-iron-sulfur (Ni-4Fe-5S)3 Publications1
Metal bindingi526Nickel-iron-sulfur (Ni-4Fe-5S)3 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, Nickel

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CHYD246194:G1G5B-81-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.2.7.4, 1178

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carbon monoxide dehydrogenase 2 (EC:1.2.7.43 Publications)
Short name:
CODH 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cooS2
Synonyms:cooSII
Ordered Locus Names:CHY_0085
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCarboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri246194 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCarboxydothermus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002706 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001571382 – 636Carbon monoxide dehydrogenase 2Add BLAST635

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
246194.CHY_0085

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1636
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9F8A8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9F8A8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer.3 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1151, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_030631_0_0_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
GIPACTH

Database of Orthologous Groups

More...
OrthoDBi
136177at2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01915, CODH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.30, 1 hit
3.40.50.2030, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016101, CO_DH_a-bundle
IPR010047, CODH
IPR004137, HCP/CODH
IPR016099, Prismane-like_a/b-sand
IPR011254, Prismane-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR30109, PTHR30109, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03063, Prismane, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005023, CODH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56821, SSF56821, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01702, CO_DH_cata, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9F8A8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKQNLKSTD RAVQQMLDKA KREGIQTVWD RYEAMKPQCG FGETGLCCRH
60 70 80 90 100
CLQGPCRINP FGDEPKVGIC GATAEVIVAR GLDRSIAAGA AGHSGHAKHL
110 120 130 140 150
AHTLKKAVQG KAASYMIKDR TKLHSIAKRL GIPTEGQKDE DIALEVAKAA
160 170 180 190 200
LADFHEKDTP VLWVTTVLPP SRVKVLSAHG LIPAGIDHEI AEIMHRTSMG
210 220 230 240 250
CDADAQNLLL GGLRCSLADL AGCYMGTDLA DILFGTPAPV VTESNLGVLK
260 270 280 290 300
ADAVNVAVHG HNPVLSDIIV SVSKEMENEA RAAGATGINV VGICCTGNEV
310 320 330 340 350
LMRHGIPACT HSVSQEMAMI TGALDAMILD YQCIQPSVAT IAECTGTTVI
360 370 380 390 400
TTMEMSKITG ATHVNFAEEA AVENAKQILR LAIDTFKRRK GKPVEIPNIK
410 420 430 440 450
TKVVAGFSTE AIINALSKLN ANDPLKPLID NVVNGNIRGV CLFAGCNNVK
460 470 480 490 500
VPQDQNFTTI ARKLLKQNVL VVATGCGAGA LMRHGFMDPA NVDELCGDGL
510 520 530 540 550
KAVLTAIGEA NGLGGPLPPV LHMGSCVDNS RAVALVAALA NRLGVDLDRL
560 570 580 590 600
PVVASAAEAM HEKAVAIGTW AVTIGLPTHI GVLPPITGSL PVTQILTSSV
610 620 630
KDITGGYFIV ELDPETAADK LLAAINERRA GLGLPW
Length:636
Mass (Da):66,914
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61C1011E86022A63
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti528D → H in AAG29809 (PubMed:11024270).Curated1
Sequence conflicti532A → S in AAG29809 (PubMed:11024270).Curated1
Sequence conflicti544G → W in AAG29809 (PubMed:11024270).Curated1
Sequence conflicti547L → M in AAG29809 (PubMed:11024270).Curated1
Sequence conflicti558E → Q in AAG29809 (PubMed:11024270).Curated1
Sequence conflicti583L → F in AAG29809 (PubMed:11024270).Curated1
Sequence conflicti615 – 617ETA → VQQR in AAG29809 (PubMed:11024270).Curated3
Sequence conflicti636W → R in AAG29809 (PubMed:11024270).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF249899 Genomic DNA Translation: AAG29809.1
CP000141 Genomic DNA Translation: ABB15588.1
AF244619 Genomic DNA Translation: AAG23568.1

NCBI Reference Sequences

More...
RefSeqi
WP_011343033.1, NC_007503.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABB15588; ABB15588; CHY_0085

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
chy:CHY_0085

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249899 Genomic DNA Translation: AAG29809.1
CP000141 Genomic DNA Translation: ABB15588.1
AF244619 Genomic DNA Translation: AAG23568.1
RefSeqiWP_011343033.1, NC_007503.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SU6X-ray1.64A1-636[»]
1SU7X-ray1.12A1-636[»]
1SU8X-ray1.10A1-636[»]
1SUFX-ray1.15A1-636[»]
2YIVX-ray1.28X1-636[»]
3B51X-ray1.40X4-636[»]
3B52X-ray1.50X4-636[»]
3B53X-ray1.50X4-636[»]
3I39X-ray1.36X1-636[»]
4UDXX-ray1.03X1-636[»]
4UDYX-ray1.09X1-636[»]
5FLEX-ray1.23X4-636[»]
SMRiQ9F8A8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi246194.CHY_0085

Genome annotation databases

EnsemblBacteriaiABB15588; ABB15588; CHY_0085
KEGGichy:CHY_0085

Phylogenomic databases

eggNOGiCOG1151, Bacteria
HOGENOMiCLU_030631_0_0_9
OMAiGIPACTH
OrthoDBi136177at2

Enzyme and pathway databases

BioCyciCHYD246194:G1G5B-81-MONOMER
BRENDAi1.2.7.4, 1178

Miscellaneous databases

EvolutionaryTraceiQ9F8A8

Family and domain databases

CDDicd01915, CODH, 1 hit
Gene3Di1.20.1270.30, 1 hit
3.40.50.2030, 2 hits
InterProiView protein in InterPro
IPR016101, CO_DH_a-bundle
IPR010047, CODH
IPR004137, HCP/CODH
IPR016099, Prismane-like_a/b-sand
IPR011254, Prismane-like_sf
PANTHERiPTHR30109, PTHR30109, 1 hit
PfamiView protein in Pfam
PF03063, Prismane, 1 hit
PIRSFiPIRSF005023, CODH, 1 hit
SUPFAMiSSF56821, SSF56821, 1 hit
TIGRFAMsiTIGR01702, CO_DH_cata, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOOS2_CARHZ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9F8A8
Secondary accession number(s): Q3AFX7, Q9F8L4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 130 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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