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UniProtKB - Q9F837 (MEDII_MICMH)
Protein
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
Gene
megDII
Organism
Micromonospora megalomicea subsp. nigra
Status
Functioni
Involved in the biosynthesis of the amino sugar dTDP-L-megosamine which is found in the macrolide antibiotic and antiparasitic megalomicin A. Catalyzes the reversible transfer of the amino group from L-glutamate to the C-3 position of dTDP-3-keto-4,6-deoxyglucose to yield dTDP-3-amino-3,4,6-trideoxyglucose.
3 PublicationsCatalytic activityi
- 2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-α-D-glucose = dTDP-3-dehydro-4,6-dideoxy-α-D-glucose + L-glutamate1 PublicationEC:2.6.1.1061 Publication
Cofactori
pyridoxal 5'-phosphateBy similarity
: Antibiotic biosynthesis Pathwayi
This protein is involved in Antibiotic biosynthesis.CuratedView all proteins of this organism that are known to be involved in Antibiotic biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 60 | Pyridoxal phosphate; via amide nitrogenBy similarity | 1 | |
Binding sitei | 160 | Pyridoxal phosphateBy similarity | 1 | |
Binding sitei | 214 | Pyridoxal phosphateBy similarity | 1 | |
Binding sitei | 221 | Pyridoxal phosphateBy similarity | 1 | |
Binding sitei | 316 | Pyridoxal phosphateBy similarity | 1 |
GO - Molecular functioni
- pyridoxal phosphate binding Source: UniProtKB
- transaminase activity Source: UniProtKB
GO - Biological processi
- macrolide biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Transferase |
Biological process | Antibiotic biosynthesis |
Ligand | Pyridoxal phosphate |
Names & Taxonomyi
Protein namesi | Recommended name: dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase1 Publication (EC:2.6.1.1061 Publication) |
Gene namesi | Name:megDII1 Publication |
Organismi | Micromonospora megalomicea subsp. nigra |
Taxonomic identifieri | 136926 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Micromonosporales › Micromonosporaceae › Micromonospora › |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000430833 | 1 – 374 | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminaseAdd BLAST | 374 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 186 | N6-(pyridoxal phosphate)lysineBy similarity | 1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 181 – 186 | Pyridoxal phosphate bindingBy similarity | 6 | |
Regioni | 229 – 231 | Pyridoxal phosphate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the degT/dnrJ/eryC1 family.Curated
Family and domain databases
CDDi | cd00616, AHBA_syn, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR000653, DegT/StrS_aminotransferase IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
PANTHERi | PTHR30244, PTHR30244, 1 hit |
Pfami | View protein in Pfam PF01041, DegT_DnrJ_EryC1, 1 hit |
PIRSFi | PIRSF000390, PLP_StrS, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9F837-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTYVWSYLL EYERERADIL DAVQKVFASG SLILGQSVEN FETEYARYHG
60 70 80 90 100
IAHCVGVDNG TNAVKLALES VGVGRDDEVV TVSNTAAPTV LAIDEIGARP
110 120 130 140 150
VFVDVRDEDY LMDTDLVEAA VTPRTKAIVP VHLYGQCVDM TALRELADRR
160 170 180 190 200
GLKLVEDCAQ AHGARRDGRL AGTMSDAAAF SFYPTKVLGA YGDGGAVVTN
210 220 230 240 250
DDETARALRR LRYYGMEEVY YVTRTPGHNS RLDEVQAEIL RRKLTRLDAY
260 270 280 290 300
VAGRRAVAQR YVDGLADLQD SHGLELPVVT DGNEHVFYVY VVRHPRRDEI
310 320 330 340 350
IKRLRDGYDI SLNISYPWPV HTMTGFAHLG VASGSLPVTE RLAGEIFSLP
360 370
MYPSLPHDLQ DRVIEAVREV ITGL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF263245 Genomic DNA Translation: AAG13910.1 |
Genome annotation databases
KEGGi | ag:AAG13910 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF263245 Genomic DNA Translation: AAG13910.1 |
3D structure databases
SMRi | Q9F837 |
ModBasei | Search... |
Genome annotation databases
KEGGi | ag:AAG13910 |
Family and domain databases
CDDi | cd00616, AHBA_syn, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR000653, DegT/StrS_aminotransferase IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
PANTHERi | PTHR30244, PTHR30244, 1 hit |
Pfami | View protein in Pfam PF01041, DegT_DnrJ_EryC1, 1 hit |
PIRSFi | PIRSF000390, PLP_StrS, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MEDII_MICMH | |
Accessioni | Q9F837Primary (citable) accession number: Q9F837 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 29, 2014 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families