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Protein

Chlorite dismutase

Gene

cld

Organism
Ideonella dechloratans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the heme-dependent decomposition of chlorite to O2 and chloride with high efficiency and specificity. Used to detoxify chlorite, a by-product of the reduction of perchlorate, a primarily anthropogenic pollutant, in perchlorate-respiring bacteria.2 Publications

Catalytic activityi

Chloride + O2 = chlorite.1 Publication

Cofactori

heme b2 PublicationsNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.2 Publications

Kineticsi

  1. KM=0.26 mM for chlorite1 Publication
  1. Vmax=4.3 mmol/min/mg enzyme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi105CalciumBy similarity1
Metal bindingi205Iron (heme axial ligand); via tele nitrogenBy similarity1
Active sitei218Proton acceptorBy similarity1
Metal bindingi227CalciumBy similarity1
Metal bindingi266Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

  • chlorite O2-lyase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

Keywordsi

Molecular functionOxidoreductase
LigandCalcium, Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chlorite dismutase (EC:1.13.11.49)
Alternative name(s):
Chlorite O(2)-lyase
Gene namesi
Name:cld
OrganismiIdeonella dechloratans
Taxonomic identifieri36863 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesIdeonella

Subcellular locationi

GO - Cellular componenti

  • periplasmic space Source: UniProtKB

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 382 PublicationsAdd BLAST38
ChainiPRO_500006662439 – 285Chlorite dismutaseAdd BLAST247

Proteomic databases

PRIDEiQ9F437

Expressioni

Inductioni

Expressed under aerobic conditions. Significantly increased upon shift to anaerobic conditions.1 Publication

Interactioni

Subunit structurei

Homopentamer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9F437
SMRiQ9F437
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chlorite dismutase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK09162

Family and domain databases

InterProiView protein in InterPro
IPR011008 Dimeric_a/b-barrel
IPR010644 Put_peroxidase/dismutase
PANTHERiPTHR36843 PTHR36843, 1 hit
PfamiView protein in Pfam
PF06778 Chlor_dismutase, 1 hit
SUPFAMiSSF54909 SSF54909, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9F437-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVRCVSLVA AGLLTIAGSA IGQPAPAPMP AMAPAAKPAM NTPVDRAKIL
60 70 80 90 100
SAPGVFVAFS TYKIRPDYFK VALAERKGAA DEVMAVLEKH KEKVIVDAYL
110 120 130 140 150
TRGYEAKSDY FLRVHAYDAV AAQAFLVDFR ATRFGMYSDV TESLVGITKA
160 170 180 190 200
LNYISKDKSP DLNKGLSGAT YAGDAPRFAF MIPVKKNADW WNLTDEQRLK
210 220 230 240 250
EMETHTLPTL PFLVNVKRKL YHSTGLDDTD FITYFETNDL GAFNNLMLSL
260 270 280
AKVPENKYHV RWGNPTVLGT IQPIENLVKT LSMGN
Length:285
Mass (Da):31,429
Last modified:March 1, 2001 - v1
Checksum:iBE83EA65AB19D9D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59F → P AA sequence (PubMed:11472023).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ296077 Genomic DNA Translation: CAC14884.1

Genome annotation databases

KEGGiag:CAC14884

Similar proteinsi

Entry informationi

Entry nameiCLD_IDEDE
AccessioniPrimary (citable) accession number: Q9F437
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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