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Protein

DNA polymerase III subunit alpha

Gene

dnaE

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SAUR93061:G1G5Y-1683-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase III subunit alpha (EC:2.7.7.7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dnaE
Ordered Locus Names:SAOUHSC_01811
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus aureus (strain NCTC 8325)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri93061 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008816 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001033421 – 1065DNA polymerase III subunit alphaAdd BLAST1065

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9F1K0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
93061.SAOUHSC_01811

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9F1K0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9F1K0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C0B Bacteria
COG0587 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000021785

KEGG Orthology (KO)

More...
KOi
K02337

Identification of Orthologs from Complete Genome Data

More...
OMAi
KSHSTCY

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011708 DNA_pol3_alpha_NTPase_dom
IPR029460 DNAPol_HHH
IPR004365 NA-bd_OB_tRNA
IPR004013 PHP_dom
IPR003141 Pol/His_phosphatase_N
IPR016195 Pol/histidinol_Pase-like
IPR004805 PolC_alpha

The PANTHER Classification System

More...
PANTHERi
PTHR32294 PTHR32294, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07733 DNA_pol3_alpha, 1 hit
PF14579 HHH_6, 1 hit
PF02811 PHP, 1 hit
PF01336 tRNA_anti-codon, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00481 POLIIIAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF89550 SSF89550, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00594 polc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9F1K0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAYLNIHTA YDLLNSSLKI EDAVRLAVSE NVDALAITDT NVLYGFPKFY
60 70 80 90 100
DACIANNIKP IFGMTIYVTN GLNTVETVVL AKNNDGLKDL YQLSSEIKMN
110 120 130 140 150
ALEHVSFELL KRFSNNMIII FKKVGDQHRD IVQVFETHND TYMDHLSISI
160 170 180 190 200
QGRKHVWIQN VCYQTRQDAD TISALAAIRD NTKLDLIHDQ EDFGAHFLTE
210 220 230 240 250
KEINQLDINQ EYLTQVDVIA QKCDAELKYH QSLLPQYETP NDESAKKYLW
260 270 280 290 300
RVLVTQLKKL ELNYDVYLER LKYEYKVITN MGFEDYFLIV SDLIHYAKTN
310 320 330 340 350
DVMVGPGRGS SAGSLVSYLL GITTIDPIKF NLLFERFLNP ERVTMPDIDI
360 370 380 390 400
DFEDTRRERV IQYVQEKYGE LHVSGIVTFG HLLARAVARD VGRIMGFDEV
410 420 430 440 450
TLNEISSLIP HKLGITLDEA YQIDDFKEFV HRNHRHERWF SICKKLEGLP
460 470 480 490 500
RHTSTHAAGI IINDHPLYEY APLTKGDTGL LTQWTMTEAE RIGLLKIDFL
510 520 530 540 550
GLRNLSIIHQ ILTQVKKDLG INIDIEKIPF DDQKVFELLS QGDTTGIFQL
560 570 580 590 600
ESDGVRSVLK KLKPEHFEDI VAVTSLYRPG PMEEIPTYIT RRHDPSKVQY
610 620 630 640 650
LHPHLEPILK NTYGVIIYQE QIMQIASTFA NFSYGEADIL RRAMSKKNRA
660 670 680 690 700
VLESERQHFI EGAKQNGYHE DISKQIFDLI LKFADYGFPR AHAVSYSKIA
710 720 730 740 750
YIMSFLKVHY PNYFYANILS NVIGSEKKTA QMIEEAKKQG ITILPPNINE
760 770 780 790 800
SHWFYKPSQE GIYLSIGTIK GVGYQSVKVI VDERYQNGKF KDFFDFARRI
810 820 830 840 850
PKRVKTRKLL EALILVGAFD AFGKTRSTLL QAIDQVLDGD LNIEQDGFLF
860 870 880 890 900
DILTPKQMYE DKEELPDALI SQYEKEYLGF YVSQHPVDKK FVAKQYLTIF
910 920 930 940 950
KLSNAQNYKP ILVQFDKVKQ IRTKNGQNMA FVTLNDGIET LDGVIFPNQF
960 970 980 990 1000
KKYEELLSHN DLFIVSGKFD HRKQQRQLII NEIQTLATFE EQKLAFAKQI
1010 1020 1030 1040 1050
IIRNKSQIDM FEEMIKATKE NANDVVLSFY DETIKQMTTL GYINQKDSMF
1060
NNFIQSFNPS DIRLI
Length:1,065
Mass (Da):122,965
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7E4196B91EBCF7C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB053352 Genomic DNA Translation: BAB20884.1
CP000253 Genomic DNA Translation: ABD30879.1

NCBI Reference Sequences

More...
RefSeqi
WP_000226907.1, NZ_LS483365.1
YP_500316.1, NC_007795.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABD30879; ABD30879; SAOUHSC_01811

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3919281

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sao:SAOUHSC_01811

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|93061.5.peg.1651

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053352 Genomic DNA Translation: BAB20884.1
CP000253 Genomic DNA Translation: ABD30879.1
RefSeqiWP_000226907.1, NZ_LS483365.1
YP_500316.1, NC_007795.1

3D structure databases

ProteinModelPortaliQ9F1K0
SMRiQ9F1K0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_01811

Proteomic databases

PRIDEiQ9F1K0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD30879; ABD30879; SAOUHSC_01811
GeneIDi3919281
KEGGisao:SAOUHSC_01811
PATRICifig|93061.5.peg.1651

Phylogenomic databases

eggNOGiENOG4105C0B Bacteria
COG0587 LUCA
HOGENOMiHOG000021785
KOiK02337
OMAiKSHSTCY

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-1683-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9F1K0

Family and domain databases

InterProiView protein in InterPro
IPR011708 DNA_pol3_alpha_NTPase_dom
IPR029460 DNAPol_HHH
IPR004365 NA-bd_OB_tRNA
IPR004013 PHP_dom
IPR003141 Pol/His_phosphatase_N
IPR016195 Pol/histidinol_Pase-like
IPR004805 PolC_alpha
PANTHERiPTHR32294 PTHR32294, 1 hit
PfamiView protein in Pfam
PF07733 DNA_pol3_alpha, 1 hit
PF14579 HHH_6, 1 hit
PF02811 PHP, 1 hit
PF01336 tRNA_anti-codon, 1 hit
SMARTiView protein in SMART
SM00481 POLIIIAc, 1 hit
SUPFAMiSSF89550 SSF89550, 1 hit
TIGRFAMsiTIGR00594 polc, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPO3A_STAA8
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9F1K0
Secondary accession number(s): Q2FXM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: December 5, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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