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Entry version 110 (02 Dec 2020)
Sequence version 2 (05 May 2009)
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Protein

Serine protease EspC

Gene

espC

Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine protease with enterotoxic and cytotoxic activities. Cleaves fodrin, but does not cause its redistribution within epithelial cells. The exact role of EspC in EPEC pathogenesis is still unknown.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibition of cytotoxic activity by phenylmethylsulfonyl fluoride.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei125Charge relay systemPROSITE-ProRule annotation1
Active sitei153Charge relay systemPROSITE-ProRule annotation1
Active sitei256Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processVirulence

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S06.010

Transport Classification Database

More...
TCDBi
1.B.12.4.1, the autotransporter-1 (at-1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine protease EspC (EC:3.4.21.-)
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:espC
Ordered Locus Names:E2348C_2915
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli O127:H6 (strain E2348/69 / EPEC)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri574521 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008205 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell outer membrane, Membrane, Periplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi256S → I: Abolishes protease and cytotoxic activities. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 531 PublicationAdd BLAST53
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004175854 – 1305Serine protease EspCAdd BLAST1252
ChainiPRO_000038759254 – 1018Secreted autotransporter protein EspCAdd BLAST965
ChainiPRO_00000417591019 – 1305Autotransporter protein EspC translocatorBy similarityAdd BLAST287

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved to release the mature protein from the outer membrane.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1018 – 1019CleavageBy similarity2

Keywords - PTMi

Zymogen

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9EZE7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is repressed by glucose.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9EZE7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 297Peptidase S6PROSITE-ProRule annotationAdd BLAST243
Domaini1039 – 1305AutotransporterPROSITE-ProRule annotationAdd BLAST267

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage (Probable).Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000723_0_0_6

Identification of Orthologs from Complete Genome Data

More...
OMAi
IIGFRVG

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.160.20.20, 1 hit
2.40.128.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005546, Autotransporte_beta
IPR036709, Autotransporte_beta_dom_sf
IPR024973, ESPR
IPR006315, OM_autotransptr_brl
IPR012332, P22_tailspike-like_C_sf
IPR011050, Pectin_lyase_fold/virulence
IPR000710, Peptidase_S6
IPR030396, Peptidase_S6_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03797, Autotransporter, 1 hit
PF13018, ESPR, 1 hit
PF02395, Peptidase_S6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00921, IGASERPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00869, Autotransporter, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103515, SSF103515, 1 hit
SSF51126, SSF51126, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01414, autotrans_barl, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51208, AUTOTRANSPORTER, 1 hit
PS51691, PEPTIDASE_S6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EZE7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKIYALKYC HATGGLIAVS ELASRVMKKA ARGSLLALFN LSLYGAFLSA
60 70 80 90 100
SQAAQLNIDN VWARDYLDLA QNKGVFKAGA TNVSIQLKNG QTFNFPNVPI
110 120 130 140 150
PDFSPASNKG ATTSIGGAYS VTATHNGTTH HAISTQNWGQ SSYKYIDRMT
160 170 180 190 200
NGDFAVTRLD KFVVETTGVK NSVDFSLNSH DALERYGVEI NGEKKIIGFR
210 220 230 240 250
VGAGTTYTVQ NGNTYSTGQV YNPLLLSASM FQLNWDNKRP YNNTTPFYNE
260 270 280 290 300
TTGGDSGSGF YLYDNVKKEW VMLGTLFGIA SSGADVWSIL NQYDENTVNG
310 320 330 340 350
LKNKFTQKVQ LNNNTMSLNS DSFTLAGNNT AVEKNNNNYK DLSFSGGGSI
360 370 380 390 400
NFDNDVNIGS GGLIFDAGHH YTVTGNNKTF KGAGLDIGDN TTVDWNVKGV
410 420 430 440 450
VGDNLHKIGA GTLNVNVSQG NNLKTGDGLV VLNSANAFDN IYMASGHGVV
460 470 480 490 500
KINHSAALNQ NNDYRGIFFT ENGGTLDLNG YDQSFNKIAA TDIGALITNS
510 520 530 540 550
AVQKAVLSVN NQSNYMYHGS VSGNTEINHQ FDTQKNNSRL ILDGNVDITN
560 570 580 590 600
DINIKNSQLT MQGHATSHAV FREGGVTCML PGVICEKDYV SGIQQQENSA
610 620 630 640 650
NKNNNTDYKT NNQVSSFEQP DWENRLFKFK TLNLINSDFI VGRNAIVVGD
660 670 680 690 700
ISANNSTLSL SGKDTKVHID MYDGKNITGD GFGFRQDIKD GVSVSPESSS
710 720 730 740 750
YFGNVTLNNH SLLDIGNKFT GGIEAYDSSV SVTSQNAVFD RVGSFVNSSL
760 770 780 790 800
TLEKGAKLTA QGGIFSTGAV DVKENASLIL TGTPSAQKQE YYSPVISTTE
810 820 830 840 850
GINLGDKASL SVKNMGYLSS DIHAGTTAAT INLGDGDAET DSPLFSSLMK
860 870 880 890 900
GYNAVLSGNI TGEQSTVNMN NALWYSDGNS TIGTLKSTGG RVELGGGKDF
910 920 930 940 950
ATLRVKELNA NNATFLMHTN NSQADQLNVT NKLLGSNNTV LVDFLNKPAS
960 970 980 990 1000
EMNVTLITAP KGSDEKTFTA GTQQIGFSNV TPVISTEKTD DATKWMLTGY
1010 1020 1030 1040 1050
QTVSDAGASK TATDFMASGY KSFLTEVNNL NKRMGDLRDT QGDAGVWARI
1060 1070 1080 1090 1100
MNGTGSADGG YSDNYTHVQI GADRKHELDG VDLFTGALLT YTDSNASSHA
1110 1120 1130 1140 1150
FSGKTKSVGG GLYASALFDS GAYFDLIGKY LHHDNQYTAS FASLGTKDYS
1160 1170 1180 1190 1200
SHSWYAGAEV GYRYHLSEES WVEPQMELVY GSVSGKSFSW EDRGMALSMK
1210 1220 1230 1240 1250
DKDYNPLIGR TGVDVGRTFS GDDWKITARA GLGYQFDLLA NGETVLRDAS
1260 1270 1280 1290 1300
GEKRFEGEKD SRMLMNVGMN AEIKDNMRFG LELEKSAFGK YNVDNAINAN

FRYSF
Length:1,305
Mass (Da):140,782
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8ECE9ED225CDFF5C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC44731 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55Q → G AA sequence (PubMed:7644526).Curated1
Sequence conflicti209V → A in AAC44731 (PubMed:8932311).Curated1
Sequence conflicti287W → G in AAC44731 (PubMed:8932311).Curated1
Sequence conflicti333E → A in AAC44731 (PubMed:8932311).Curated1
Sequence conflicti514N → H in AAC44731 (PubMed:8932311).Curated1
Sequence conflicti849 – 850MK → IR in AAC44731 (PubMed:8932311).Curated2
Sequence conflicti921N → T in AAC44731 (PubMed:8932311).Curated1
Sequence conflicti1189S → I in AAC44731 (PubMed:8932311).Curated1
Sequence conflicti1300N → D in AAG37043 (PubMed:11119520).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U69128 Genomic DNA Translation: AAC44731.1 Frameshift.
AF297061 Genomic DNA Translation: AAG37043.1
FM180568 Genomic DNA Translation: CAS10463.1

NCBI Reference Sequences

More...
RefSeqi
WP_001034000.1, NC_011601.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAS10463; CAS10463; E2348C_2915

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecg:E2348C_2915

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69128 Genomic DNA Translation: AAC44731.1 Frameshift.
AF297061 Genomic DNA Translation: AAG37043.1
FM180568 Genomic DNA Translation: CAS10463.1
RefSeqiWP_001034000.1, NC_011601.1

3D structure databases

SMRiQ9EZE7
ModBaseiSearch...

Protein family/group databases

MEROPSiS06.010
TCDBi1.B.12.4.1, the autotransporter-1 (at-1) family

Proteomic databases

PRIDEiQ9EZE7

Genome annotation databases

EnsemblBacteriaiCAS10463; CAS10463; E2348C_2915
KEGGiecg:E2348C_2915

Phylogenomic databases

HOGENOMiCLU_000723_0_0_6
OMAiIIGFRVG

Family and domain databases

Gene3Di2.160.20.20, 1 hit
2.40.128.130, 1 hit
InterProiView protein in InterPro
IPR005546, Autotransporte_beta
IPR036709, Autotransporte_beta_dom_sf
IPR024973, ESPR
IPR006315, OM_autotransptr_brl
IPR012332, P22_tailspike-like_C_sf
IPR011050, Pectin_lyase_fold/virulence
IPR000710, Peptidase_S6
IPR030396, Peptidase_S6_dom
PfamiView protein in Pfam
PF03797, Autotransporter, 1 hit
PF13018, ESPR, 1 hit
PF02395, Peptidase_S6, 1 hit
PRINTSiPR00921, IGASERPTASE
SMARTiView protein in SMART
SM00869, Autotransporter, 1 hit
SUPFAMiSSF103515, SSF103515, 1 hit
SSF51126, SSF51126, 2 hits
TIGRFAMsiTIGR01414, autotrans_barl, 1 hit
PROSITEiView protein in PROSITE
PS51208, AUTOTRANSPORTER, 1 hit
PS51691, PEPTIDASE_S6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESPC_ECO27
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9EZE7
Secondary accession number(s): B7UH71, P77070
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: May 5, 2009
Last modified: December 2, 2020
This is version 110 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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