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Protein

Junctophilin-3

Gene

Jph3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.2 Publications

GO - Molecular functioni

  • calcium-release channel activity Source: UniProtKB

GO - Biological processi

  • exploration behavior Source: UniProtKB
  • learning Source: MGI
  • locomotion Source: MGI
  • memory Source: UniProtKB
  • neuromuscular process controlling balance Source: MGI
  • regulation of neuronal synaptic plasticity Source: UniProtKB
  • regulation of ryanodine-sensitive calcium-release channel activity Source: UniProtKB
  • regulation of synaptic plasticity Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Junctophilin-3
Short name:
JP-3
Alternative name(s):
Junctophilin type 3
Gene namesi
Name:Jph3
Synonyms:Jp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1891497 Jph3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 723CytoplasmicSequence analysisAdd BLAST723
Transmembranei724 – 744Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile, but have defects in balance/motor coordination tasks. Jph3 and Jph4 double knockout mice exhibit atypical depolarizing responses, irregular cerebellar plasticity due to abolished crosstalk in Purkinje cells. There is hyperphosphorylation of PRKCG and mild impairment of synaptic maturation. Exploratory activity, hippocampal plasticity and memory are impaired and there is abnormal foot-clasping reflex.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001598511 – 744Junctophilin-3Add BLAST744

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei440PhosphoserineCombined sources1
Modified residuei451PhosphothreonineCombined sources1
Modified residuei457PhosphoserineCombined sources1
Modified residuei471PhosphothreonineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei506PhosphoserineCombined sources1
Modified residuei699PhosphoserineCombined sources1
Modified residuei706PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ET77
PaxDbiQ9ET77
PRIDEiQ9ET77

PTM databases

iPTMnetiQ9ET77
PhosphoSitePlusiQ9ET77

Expressioni

Tissue specificityi

Specifically expressed in brain. Highest levels in the olfactory tubercle, caudate putamen, nucleus accumbens, hippocampal formation, piriform cortex and cerebellar cortex. Expressed in disctete neurons sites. In hippocampal formation, expressed in dendrites of hippocampal pyramidal and denate granule cells. In cerebellum, it is highly expressed in Purkinge cells, while it is weakly expressed in granular cells.2 Publications

Gene expression databases

BgeeiENSMUSG00000025318 Expressed in 119 organ(s), highest expression level in CA1 field of hippocampus
CleanExiMM_JPH3
GenevisibleiQ9ET77 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026357

Structurei

3D structure databases

ProteinModelPortaliQ9ET77
SMRiQ9ET77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 37MORN 1Add BLAST23
Repeati39 – 60MORN 2Add BLAST22
Repeati61 – 82MORN 3Add BLAST22
Repeati83 – 105MORN 4Add BLAST23
Repeati107 – 129MORN 5Add BLAST23
Repeati130 – 152MORN 6Add BLAST23
Repeati288 – 310MORN 7Add BLAST23
Repeati311 – 333MORN 8Add BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 143Gly-richAdd BLAST140
Compositional biasi366 – 416Ala-richAdd BLAST51

Domaini

The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids.By similarity

Sequence similaritiesi

Belongs to the junctophilin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0231 Eukaryota
COG4642 LUCA
GeneTreeiENSGT00730000110639
HOGENOMiHOG000264244
HOVERGENiHBG031648
InParanoidiQ9ET77
KOiK19530
OMAiKLSNYEM
OrthoDBiEOG091G03WX
PhylomeDBiQ9ET77
TreeFamiTF317210

Family and domain databases

InterProiView protein in InterPro
IPR017191 Junctophilin
IPR003409 MORN
PANTHERiPTHR23085 PTHR23085, 1 hit
PfamiView protein in Pfam
PF02493 MORN, 7 hits
PIRSFiPIRSF037387 Junctophilin, 1 hit
SMARTiView protein in SMART
SM00698 MORN, 7 hits

Sequencei

Sequence statusi: Complete.

Q9ET77-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSGGRFNFD DGGSYCGGWE DGKAHGHGVC TGPKGQGEYT GSWSHGFEVL
60 70 80 90 100
GVYTWPSGNT YQGTWAQGKR HGIGLESKGK WVYKGEWTHG FKGRYGVREC
110 120 130 140 150
TGNGAKYEGT WSNGLQDGYG TETYSDGGTY QGQWVGGMRQ GYGVRQSVPY
160 170 180 190 200
GMAAVIRSPL RTSINSLRSE HTNGAALHPD ASPAVAGSPA VSRGGFVLVA
210 220 230 240 250
HSDSEILKSK KKGLFRRSLL SGLKLRKSES KSSLASQRSK QSSFRSEAGM
260 270 280 290 300
STVSSTASDI HSTISLGEAE AELAVIEDDI DATTTETYVG EWKNDKRSGF
310 320 330 340 350
GVSQRSDGLK YEGEWVSNRR HGYGCMTFPD GTKEEGKYKQ NVLVSGKRKN
360 370 380 390 400
LIPLRASKIR EKVDRAVEAA ERAATIAKQK AEIAASRTSH SRAKAEAALT
410 420 430 440 450
AAQKAQEEAR IARITAKEFS PSFQHRENGL EYQRPKHQMS CDDIEVLSTG
460 470 480 490 500
TPLQQESPEL YRKGTTPSDL TPDDSPLQSF PASPTSTPPP APASRTKMAH
510 520 530 540 550
FSRQVSVDEE RSGDIQMLLE GRGGDYARNS WGEEKAGASR GIRSGALRSG
560 570 580 590 600
QPTEDFRTRG SGHKQPGNPK PRERRTESPT TFSWTSHHRA GNPCSGGPKL
610 620 630 640 650
LEPDEEQLSN YKLEMKPLLR MDACPQDTHP QRRRHSRGAG GDRGFGLQRL
660 670 680 690 700
RSKSQNKENL RPASSAEPTV QKLESLRLGD RPEPRLLRWD LTFSPPQKSL
710 720 730 740
PVALESDEET GDELKSSTGS APILVVMVIL LNIGVAILFI NFFI
Length:744
Mass (Da):81,229
Last modified:March 1, 2001 - v1
Checksum:i3D72AED6A6FDA914
GO

Sequence cautioni

The sequence BAC38666 differs from that shown. Reason: Erroneous termination at position 745. Translated as stop.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024449 mRNA Translation: BAB12046.1
AB024450 Genomic DNA Translation: BAB20320.1
AK082880 mRNA Translation: BAC38666.1 Sequence problems.
BC103682 mRNA Translation: AAI03683.1
BC104736 mRNA Translation: AAI04737.1
BC105307 mRNA Translation: AAI05308.1
CCDSiCCDS22728.1
RefSeqiNP_065630.1, NM_020605.3
UniGeneiMm.306870

Genome annotation databases

EnsembliENSMUST00000026357; ENSMUSP00000026357; ENSMUSG00000025318
ENSMUST00000167439; ENSMUSP00000126190; ENSMUSG00000025318
GeneIDi57340
KEGGimmu:57340
UCSCiuc009nrz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024449 mRNA Translation: BAB12046.1
AB024450 Genomic DNA Translation: BAB20320.1
AK082880 mRNA Translation: BAC38666.1 Sequence problems.
BC103682 mRNA Translation: AAI03683.1
BC104736 mRNA Translation: AAI04737.1
BC105307 mRNA Translation: AAI05308.1
CCDSiCCDS22728.1
RefSeqiNP_065630.1, NM_020605.3
UniGeneiMm.306870

3D structure databases

ProteinModelPortaliQ9ET77
SMRiQ9ET77
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026357

PTM databases

iPTMnetiQ9ET77
PhosphoSitePlusiQ9ET77

Proteomic databases

MaxQBiQ9ET77
PaxDbiQ9ET77
PRIDEiQ9ET77

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026357; ENSMUSP00000026357; ENSMUSG00000025318
ENSMUST00000167439; ENSMUSP00000126190; ENSMUSG00000025318
GeneIDi57340
KEGGimmu:57340
UCSCiuc009nrz.2 mouse

Organism-specific databases

CTDi57338
MGIiMGI:1891497 Jph3

Phylogenomic databases

eggNOGiKOG0231 Eukaryota
COG4642 LUCA
GeneTreeiENSGT00730000110639
HOGENOMiHOG000264244
HOVERGENiHBG031648
InParanoidiQ9ET77
KOiK19530
OMAiKLSNYEM
OrthoDBiEOG091G03WX
PhylomeDBiQ9ET77
TreeFamiTF317210

Miscellaneous databases

ChiTaRSiJph3 mouse
PROiPR:Q9ET77
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025318 Expressed in 119 organ(s), highest expression level in CA1 field of hippocampus
CleanExiMM_JPH3
GenevisibleiQ9ET77 MM

Family and domain databases

InterProiView protein in InterPro
IPR017191 Junctophilin
IPR003409 MORN
PANTHERiPTHR23085 PTHR23085, 1 hit
PfamiView protein in Pfam
PF02493 MORN, 7 hits
PIRSFiPIRSF037387 Junctophilin, 1 hit
SMARTiView protein in SMART
SM00698 MORN, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiJPH3_MOUSE
AccessioniPrimary (citable) accession number: Q9ET77
Secondary accession number(s): Q3ZAS3, Q8BNM7, Q9EQZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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