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Protein

Krueppel-like factor 2

Gene

Klf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri268 – 292C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri298 – 322C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri328 – 350C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 2
Alternative name(s):
Lung krueppel-like factor
Gene namesi
Name:Klf2
Synonyms:Lklf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1359220 Klf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471641 – 351Krueppel-like factor 2Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171PhosphothreonineCombined sources1
Modified residuei240PhosphothreonineCombined sources1
Modified residuei243PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9ET58
PRIDEiQ9ET58

PTM databases

iPTMnetiQ9ET58
PhosphoSitePlusiQ9ET58

Expressioni

Gene expression databases

BgeeiENSRNOG00000014205 Expressed in 10 organ(s), highest expression level in lung
GenevisibleiQ9ET58 RN

Interactioni

Subunit structurei

Interacts with WWP1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019052

Structurei

3D structure databases

ProteinModelPortaliQ9ET58
SMRiQ9ET58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 264Interaction with WWP1By similarityAdd BLAST155

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi60 – 70Poly-ProAdd BLAST11
Compositional biasi165 – 168Poly-Pro4
Compositional biasi224 – 227Poly-Ala4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri268 – 292C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri298 – 322C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri328 – 350C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118998
HOGENOMiHOG000060173
HOVERGENiHBG006220
InParanoidiQ9ET58
KOiK17845
OMAiNVSCMMS
OrthoDBiEOG091G1BN0
PhylomeDBiQ9ET58
TreeFamiTF350556

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q9ET58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSEPILPS FATFASPCER GLQERWPRNE PEAGSTDEDL NSVLDFILSM
60 70 80 90 100
GLDGLGAENP PEPPPQPPPP AFYYPEPGAP PPYGTPAAGL GTELLRPDLD
110 120 130 140 150
APQGPALHGR FLLAPPGRLV KAEPPEVDGG GYGCAAGLAR GPRGLKLEGA
160 170 180 190 200
LGATGACMRG PAGRPPPPSD TPPLSPDGPP RLPAPGPRNP FPPPFGPGPS
210 220 230 240 250
FGGPGPALHY GPPAPGAFGL FDDAAAALGL APPATRGLLT PPSSPLELLE
260 270 280 290 300
AKPKRGRRSW PRKRAATHTC SYTNCGKTYT KSSHLKAHLR THTGEKPYHC
310 320 330 340 350
NWDGCGWKFA RSDELTRHYR KHTGHRPFQC HLCDRAFSRS DHLALHMKRH

M
Length:351
Mass (Da):37,313
Last modified:March 1, 2001 - v1
Checksum:i2E4EB6B0577A53A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181251 Genomic DNA Translation: AAG02141.1
RefSeqiNP_001007685.1, NM_001007684.1
UniGeneiRn.92653

Genome annotation databases

EnsembliENSRNOT00000019052; ENSRNOP00000019052; ENSRNOG00000014205
GeneIDi306330
KEGGirno:306330
UCSCiRGD:1359220 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181251 Genomic DNA Translation: AAG02141.1
RefSeqiNP_001007685.1, NM_001007684.1
UniGeneiRn.92653

3D structure databases

ProteinModelPortaliQ9ET58
SMRiQ9ET58
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019052

PTM databases

iPTMnetiQ9ET58
PhosphoSitePlusiQ9ET58

Proteomic databases

PaxDbiQ9ET58
PRIDEiQ9ET58

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019052; ENSRNOP00000019052; ENSRNOG00000014205
GeneIDi306330
KEGGirno:306330
UCSCiRGD:1359220 rat

Organism-specific databases

CTDi10365
RGDi1359220 Klf2

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118998
HOGENOMiHOG000060173
HOVERGENiHBG006220
InParanoidiQ9ET58
KOiK17845
OMAiNVSCMMS
OrthoDBiEOG091G1BN0
PhylomeDBiQ9ET58
TreeFamiTF350556

Miscellaneous databases

PROiPR:Q9ET58

Gene expression databases

BgeeiENSRNOG00000014205 Expressed in 10 organ(s), highest expression level in lung
GenevisibleiQ9ET58 RN

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLF2_RAT
AccessioniPrimary (citable) accession number: Q9ET58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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