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Protein

Claudin-12

Gene

Cldn12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-12
Gene namesi
Name:Cldn12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1929288 Cldn12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 87ExtracellularSequence analysisAdd BLAST56
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 135CytoplasmicSequence analysisAdd BLAST27
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 174ExtracellularSequence analysisAdd BLAST18
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 244CytoplasmicSequence analysisAdd BLAST49

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447661 – 244Claudin-12Add BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei228PhosphoserineBy similarity1
Modified residuei231PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ET43
PaxDbiQ9ET43
PeptideAtlasiQ9ET43
PRIDEiQ9ET43

PTM databases

iPTMnetiQ9ET43
PhosphoSitePlusiQ9ET43

Expressioni

Gene expression databases

BgeeiENSMUSG00000046798 Expressed in 237 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_CLDN12
GenevisibleiQ9ET43 MM

Interactioni

Subunit structurei

Interacts with OCLN.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061928

Structurei

3D structure databases

ProteinModelPortaliQ9ET43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE44 Eukaryota
ENOG410ZR1K LUCA
GeneTreeiENSGT00400000022250
HOGENOMiHOG000036050
HOVERGENiHBG050986
InParanoidiQ9ET43
OMAiCKTCCCS
OrthoDBiEOG091G0E18
PhylomeDBiQ9ET43
TreeFamiTF331972

Family and domain databases

InterProiView protein in InterPro
IPR013287 Claudin12
IPR017974 Claudin_CS
PANTHERiPTHR16703 PTHR16703, 1 hit
PRINTSiPR01872 CLAUDIN12
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ET43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCRDVHAAT VLSFLCGIAS VAGLFAGTLL PNWRKLRLIT FNRNEKNLTI
60 70 80 90 100
YTGLWVKCAR YDGSSDCLMY DRTWYLSVDQ LDLRVLQFAL PLSIVIAMGA
110 120 130 140 150
LLLCLIGMCN TAFNSSVPNI KLAKCLVNSA GCHLVAGLLF FLAGTVSLSP
160 170 180 190 200
SIWAIFYNSH LNRKFEPVFT FDYAVFVTIA SSGGLFMTAL LLFVWYCACK
210 220 230 240
SLSSPFWQPL YSHAPGMHTY SQPYSSRSRL SAIEIDIPVV SHST
Length:244
Mass (Da):26,995
Last modified:May 16, 2003 - v2
Checksum:i5A49F3BD7C25C87E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039672 mRNA Translation: BAC30414.1
AK049331 mRNA Translation: BAC33687.1
AK132155 mRNA Translation: BAE21001.1
AK166110 mRNA Translation: BAE38577.1
BC024057 mRNA Translation: AAH24057.1
AF247664 mRNA Translation: AAF98801.1
CCDSiCCDS19074.1
RefSeqiNP_001180588.1, NM_001193659.1
NP_001180589.1, NM_001193660.1
NP_001180590.1, NM_001193661.1
NP_075028.1, NM_022890.2
XP_006503661.1, XM_006503598.3
XP_011238975.1, XM_011240673.2
XP_011238976.1, XM_011240674.1
UniGeneiMm.40132

Genome annotation databases

EnsembliENSMUST00000060947; ENSMUSP00000061928; ENSMUSG00000046798
ENSMUST00000115445; ENSMUSP00000111105; ENSMUSG00000046798
ENSMUST00000115446; ENSMUSP00000111106; ENSMUSG00000046798
ENSMUST00000179804; ENSMUSP00000136988; ENSMUSG00000046798
GeneIDi64945
KEGGimmu:64945
UCSCiuc008wip.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039672 mRNA Translation: BAC30414.1
AK049331 mRNA Translation: BAC33687.1
AK132155 mRNA Translation: BAE21001.1
AK166110 mRNA Translation: BAE38577.1
BC024057 mRNA Translation: AAH24057.1
AF247664 mRNA Translation: AAF98801.1
CCDSiCCDS19074.1
RefSeqiNP_001180588.1, NM_001193659.1
NP_001180589.1, NM_001193660.1
NP_001180590.1, NM_001193661.1
NP_075028.1, NM_022890.2
XP_006503661.1, XM_006503598.3
XP_011238975.1, XM_011240673.2
XP_011238976.1, XM_011240674.1
UniGeneiMm.40132

3D structure databases

ProteinModelPortaliQ9ET43
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061928

PTM databases

iPTMnetiQ9ET43
PhosphoSitePlusiQ9ET43

Proteomic databases

MaxQBiQ9ET43
PaxDbiQ9ET43
PeptideAtlasiQ9ET43
PRIDEiQ9ET43

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060947; ENSMUSP00000061928; ENSMUSG00000046798
ENSMUST00000115445; ENSMUSP00000111105; ENSMUSG00000046798
ENSMUST00000115446; ENSMUSP00000111106; ENSMUSG00000046798
ENSMUST00000179804; ENSMUSP00000136988; ENSMUSG00000046798
GeneIDi64945
KEGGimmu:64945
UCSCiuc008wip.2 mouse

Organism-specific databases

CTDi9069
MGIiMGI:1929288 Cldn12

Phylogenomic databases

eggNOGiENOG410IE44 Eukaryota
ENOG410ZR1K LUCA
GeneTreeiENSGT00400000022250
HOGENOMiHOG000036050
HOVERGENiHBG050986
InParanoidiQ9ET43
OMAiCKTCCCS
OrthoDBiEOG091G0E18
PhylomeDBiQ9ET43
TreeFamiTF331972

Miscellaneous databases

PROiPR:Q9ET43
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046798 Expressed in 237 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_CLDN12
GenevisibleiQ9ET43 MM

Family and domain databases

InterProiView protein in InterPro
IPR013287 Claudin12
IPR017974 Claudin_CS
PANTHERiPTHR16703 PTHR16703, 1 hit
PRINTSiPR01872 CLAUDIN12
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD12_MOUSE
AccessioniPrimary (citable) accession number: Q9ET43
Secondary accession number(s): Q3TM65, Q8BH13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 16, 2003
Last modified: September 12, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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