UniProtKB - Q9ET39 (SLAF6_MOUSE)
SLAM family member 6
Slamf6
Functioni
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922).
Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (By similarity).
Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (By similarity).
In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (PubMed:18031695).
Promotes T cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (By similarity).
Promotes recruitment of RORC to the IL-17 promoter (By similarity).
In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response (PubMed:25926831).
In the absence of SH2D1A/SAP can transmit negative signals to CD4+ T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP (PubMed:22683125).
However, reported to mediated T-cell adhesion, to participate in stable T-cell:B-cell interactions and to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (PubMed:20153220, PubMed:25801429).
Involved in regulation of autoimmunity. Isoform 3 may be suppressor of pathogenic T-cell proliferation (PubMed:21422172).
By similarity6 PublicationsMiscellaneous
GO - Biological processi
- innate immune response Source: UniProtKB-KW
- natural killer cell differentiation Source: UniProtKB
- natural killer cell proliferation Source: UniProtKB
- positive regulation of interferon-gamma production Source: MGI
- positive regulation of interleukin-17 production Source: MGI
- positive regulation of natural killer cell mediated cytotoxicity Source: MGI
- T cell activation Source: GO_Central
- T-helper 17 cell lineage commitment Source: MGI
Keywordsi
Molecular function | Receptor |
Biological process | Adaptive immunity, Immunity, Innate immunity |
Enzyme and pathway databases
Reactomei | R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Protein family/group databases
TCDBi | 8.A.23.1.32, the basigin (basigin) family |
Names & Taxonomyi
Protein namesi | Recommended name: SLAM family member 6Alternative name(s): Lymphocyte antigen 108 CD_antigen: CD352 |
Gene namesi | Name:Slamf6 Synonyms:Ly108 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1353620, Slamf6 |
VEuPathDBi | HostDB:ENSMUSG00000015314 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- integral component of plasma membrane Source: MGI
- plasma membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 31 – 239 | ExtracellularSequence analysisAdd BLAST | 209 | |
Transmembranei | 240 – 262 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 263 – 351 | CytoplasmicSequence analysisAdd BLAST | 89 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 295 | Y → F: Decreases inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-319 and F-349. 1 Publication | 1 | |
Mutagenesisi | 295 | Y → F: Strong inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-335 and F-349. 1 Publication | 1 | |
Mutagenesisi | 319 | Y → F: Decreases inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-295 and F-349. 1 Publication | 1 | |
Mutagenesisi | 319 | Y → F: Strong inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-335 and F-349. 1 Publication | 1 | |
Mutagenesisi | 335 | Y → F: Strong inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-295 and F-349. 1 Publication | 1 | |
Mutagenesisi | 335 | Y → F: Strong inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-319 and F-349. 1 Publication | 1 | |
Mutagenesisi | 349 | Y → F: Decreases inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-295 and F-319. 1 Publication | 1 | |
Mutagenesisi | 349 | Y → F: Strong inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-295 and F-335. 1 Publication | 1 | |
Mutagenesisi | 349 | Y → F: Strong inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-319 and F-335. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000014962 | 31 – 351 | SLAM family member 6Add BLAST | 321 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 82 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 101 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 112 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 152 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 159 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 162 ↔ 229 | PROSITE-ProRule annotation | ||
Disulfide bondi | 168 ↔ 210 | PROSITE-ProRule annotation | ||
Glycosylationi | 172 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 186 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 193 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 218 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 319 | PhosphotyrosineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9ET39 |
MaxQBi | Q9ET39 |
PaxDbi | Q9ET39 |
PRIDEi | Q9ET39 |
ProteomicsDBi | 261409 [Q9ET39-1] 261410 [Q9ET39-2] 261411 [Q9ET39-3] |
PTM databases
GlyGeni | Q9ET39, 9 sites |
iPTMneti | Q9ET39 |
PhosphoSitePlusi | Q9ET39 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000015314, Expressed in spleen and 87 other tissues |
Genevisiblei | Q9ET39, MM |
Interactioni
Subunit structurei
Homodimer.
Interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000130610 |
Miscellaneous databases
RNActi | Q9ET39, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 130 | Ig-like V-typeAdd BLAST | 95 | |
Domaini | 147 – 210 | Ig-like C2-typeAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 272 – 295 | DisorderedSequence analysisAdd BLAST | 24 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 293 – 298 | ITSM 1By similarity | 6 | |
Motifi | 317 – 322 | ITSM 2By similarity | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 273 – 295 | Polar residuesSequence analysisAdd BLAST | 23 |
Domaini
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SSRG, Eukaryota |
GeneTreei | ENSGT01030000234540 |
HOGENOMi | CLU_069386_2_0_1 |
InParanoidi | Q9ET39 |
OMAi | ENRTCEI |
OrthoDBi | 990343at2759 |
PhylomeDBi | Q9ET39 |
TreeFami | TF334964 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVSRAPAPD SACQRMVWLF PLVFCLGSGS EVSQSSSDPQ LMNGVLGESA
60 70 80 90 100
VLPLKLPAGK IANIIIWNYE WEASQVTALV INLSNPESPQ IMNTDVKKRL
110 120 130 140 150
NITQSYSLQI SNLTMADTGS YTAQITTKDS EVITFKYILR VFERLGNLET
160 170 180 190 200
TNYTLLLENG TCQIHLACVL KNQSQTVSVE WQATGNISLG GPNVTIFWDP
210 220 230 240 250
RNSGDQTYVC RAKNAVSNLS VSVSTQSLCK GVLTNPPWNA VWFMTTISII
260 270 280 290 300
SAVILIFVCW SIHVWKRRGS LPLTSQHPES SQSTDGPGSP GNTVYAQVTR
310 320 330 340 350
PMQEMKIPKP IKNDSMTIYS IVNHSREETV ALTGYNQPIT LKVNTLINYN
S
The sequence of this isoform differs from the canonical sequence as follows:
305-328: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A6YY21 | A0A0A6YY21_MOUSE | SLAM family member 6 | Slamf6 | 55 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_058034 | 305 – 328 | Missing in isoform 3. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_010404 | 328 – 331 | ETVA → AEYS in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_010405 | 332 – 351 | Missing in isoform 2. 1 PublicationAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF248635 mRNA Translation: AAG01737.1 AF248636 mRNA Translation: AAG01738.1 EU591721 mRNA Translation: ACF05482.1 AC091523 Genomic DNA No translation available. BC030031 mRNA Translation: AAH30031.1 |
CCDSi | CCDS15504.1 [Q9ET39-2] CCDS83638.1 [Q9ET39-1] CCDS83639.1 [Q9ET39-3] |
RefSeqi | NP_001334115.1, NM_001347186.1 [Q9ET39-1] NP_001334116.1, NM_001347187.1 [Q9ET39-3] NP_109635.1, NM_030710.2 [Q9ET39-2] |
Genome annotation databases
Ensembli | ENSMUST00000171330; ENSMUSP00000130610; ENSMUSG00000015314 [Q9ET39-2] ENSMUST00000194561; ENSMUSP00000141944; ENSMUSG00000015314 [Q9ET39-3] ENSMUST00000195656; ENSMUSP00000141448; ENSMUSG00000015314 [Q9ET39-1] |
GeneIDi | 30925 |
KEGGi | mmu:30925 |
UCSCi | uc007dph.1, mouse [Q9ET39-1] uc011wwh.1, mouse |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF248635 mRNA Translation: AAG01737.1 AF248636 mRNA Translation: AAG01738.1 EU591721 mRNA Translation: ACF05482.1 AC091523 Genomic DNA No translation available. BC030031 mRNA Translation: AAH30031.1 |
CCDSi | CCDS15504.1 [Q9ET39-2] CCDS83638.1 [Q9ET39-1] CCDS83639.1 [Q9ET39-3] |
RefSeqi | NP_001334115.1, NM_001347186.1 [Q9ET39-1] NP_001334116.1, NM_001347187.1 [Q9ET39-3] NP_109635.1, NM_030710.2 [Q9ET39-2] |
3D structure databases
SMRi | Q9ET39 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000130610 |
Protein family/group databases
TCDBi | 8.A.23.1.32, the basigin (basigin) family |
PTM databases
GlyGeni | Q9ET39, 9 sites |
iPTMneti | Q9ET39 |
PhosphoSitePlusi | Q9ET39 |
Proteomic databases
EPDi | Q9ET39 |
MaxQBi | Q9ET39 |
PaxDbi | Q9ET39 |
PRIDEi | Q9ET39 |
ProteomicsDBi | 261409 [Q9ET39-1] 261410 [Q9ET39-2] 261411 [Q9ET39-3] |
Protocols and materials databases
ABCDi | Q9ET39, 3 sequenced antibodies |
Antibodypediai | 34279, 488 antibodies from 33 providers |
DNASUi | 30925 |
Genome annotation databases
Ensembli | ENSMUST00000171330; ENSMUSP00000130610; ENSMUSG00000015314 [Q9ET39-2] ENSMUST00000194561; ENSMUSP00000141944; ENSMUSG00000015314 [Q9ET39-3] ENSMUST00000195656; ENSMUSP00000141448; ENSMUSG00000015314 [Q9ET39-1] |
GeneIDi | 30925 |
KEGGi | mmu:30925 |
UCSCi | uc007dph.1, mouse [Q9ET39-1] uc011wwh.1, mouse |
Organism-specific databases
CTDi | 114836 |
MGIi | MGI:1353620, Slamf6 |
VEuPathDBi | HostDB:ENSMUSG00000015314 |
Phylogenomic databases
eggNOGi | ENOG502SSRG, Eukaryota |
GeneTreei | ENSGT01030000234540 |
HOGENOMi | CLU_069386_2_0_1 |
InParanoidi | Q9ET39 |
OMAi | ENRTCEI |
OrthoDBi | 990343at2759 |
PhylomeDBi | Q9ET39 |
TreeFami | TF334964 |
Enzyme and pathway databases
Reactomei | R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Miscellaneous databases
BioGRID-ORCSi | 30925, 1 hit in 64 CRISPR screens |
ChiTaRSi | Slamf6, mouse |
PROi | PR:Q9ET39 |
RNActi | Q9ET39, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000015314, Expressed in spleen and 87 other tissues |
Genevisiblei | Q9ET39, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SLAF6_MOUSE | |
Accessioni | Q9ET39Primary (citable) accession number: Q9ET39 Secondary accession number(s): C6ESQ1, Q9ET40 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot