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Protein

Claudin-19

Gene

Cldn19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.1 Publication

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • structural molecule activity Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-19
Gene namesi
Name:Cldn19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3033992 Cldn19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 117CytoplasmicSequence analysisAdd BLAST15
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 160ExtracellularSequence analysisAdd BLAST22
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 224CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi35Y → F: No effect on interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi35Y → S: Abolishes interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi38D → A: No effect on interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi39A → R: Abolishes interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi39A → S: Strongly reduces interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi40I → A, S or L: Abolishes interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi40I → V: Strongly reduces interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi41I → A, S or V: Abolishes interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi41I → L: No effect on interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi42T → A or V: No effect on interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi53S → A: No effect on interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi146Q → A: No effect on interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi147E → A, Q or R: No effect on interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi150N → A, D, Q or K: Abolishes interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi150N → S or L: Stongly inhibits interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi151P → A or G: Abolishes interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi152S → D: Abolishes interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi152S → L, M or F: No effect on interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi153T → V or L: No effect on interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi153T → Y: Abolishes interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi154P → A: Strongly inhibits interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi154P → D: Abolishes interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi155V → I: No effect on interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi156N → A or S: No effect on interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi156N → G: Strongly inhibits interaction with Clostridium perfringens CPE. 1 Publication1
Mutagenesisi159Y → S or F: Strongly inhibits interaction with Clostridium perfringens CPE. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447821 – 224Claudin-19Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 64Combined sources1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9ET38
PRIDEiQ9ET38

PTM databases

PhosphoSitePlusiQ9ET38

Expressioni

Gene expression databases

BgeeiENSMUSG00000066058 Expressed in 30 organ(s), highest expression level in sciatic nerve
CleanExiMM_CLDN19
ExpressionAtlasiQ9ET38 baseline and differential
GenevisibleiQ9ET38 MM

Interactioni

Subunit structurei

(Microbial infection) Interacts (via both extracellular domains) with Clostridium perfringens enterotoxin CPE; the interaction disrupts claudin assembly in tight junctions.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
cpeP015582EBI-8036280,EBI-16142958From Clostridium perfringens.

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-42881N
IntActiQ9ET38, 2 interactors
MINTiQ9ET38
STRINGi10090.ENSMUSP00000081334

Structurei

3D structure databases

ProteinModelPortaliQ9ET38
SMRiQ9ET38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG5H Eukaryota
ENOG410Y143 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiQ9ET38
KOiK06087
OMAiARFEFGP
OrthoDBiEOG091G0MX2
PhylomeDBiQ9ET38
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9ET38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANSGLQLLG YFLALGGWVG IIASTALPQW KQSSYAGDAI ITAVGLYEGL
60 70 80 90 100
WMSCASQSTG QVQCKLYDSL LALDGHIQSA RALMVVAVLL GFVAMVLSVV
110 120 130 140 150
GMKCTRVGDS NPTAKSRVAI SGGALFLLAG LCTLTAVSWY ATLVTQEFFN
160 170 180 190 200
PSTPVNARYE FGPALFVGWA SAGLAMLGGS FLCCTCPEPE RANSIPQPYR
210 220
SGPSTAAREP VVKLPASVKG PLGV
Length:224
Mass (Da):23,343
Last modified:May 24, 2004 - v3
Checksum:i4282BE63C4D8BCD2
GO
Isoform 2 (identifier: Q9ET38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-224: PVVKLPASVKGPLGV → YV

Show »
Length:211
Mass (Da):22,163
Checksum:iA13E7C81F091D242
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010343210 – 224PVVKL…GPLGV → YV in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486651 mRNA Translation: AAM12735.2
AK032743 mRNA Translation: BAC28005.1
AF249889 mRNA Translation: AAF98323.1
CCDSiCCDS18577.1 [Q9ET38-1]
CCDS18578.1 [Q9ET38-2]
RefSeqiNP_001033679.1, NM_001038590.1 [Q9ET38-1]
NP_694745.1, NM_153105.7 [Q9ET38-2]
UniGeneiMm.130701

Genome annotation databases

EnsembliENSMUST00000084309; ENSMUSP00000081334; ENSMUSG00000066058 [Q9ET38-1]
ENSMUST00000094823; ENSMUSP00000092418; ENSMUSG00000066058 [Q9ET38-2]
GeneIDi242653
KEGGimmu:242653
UCSCiuc008uls.1 mouse [Q9ET38-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486651 mRNA Translation: AAM12735.2
AK032743 mRNA Translation: BAC28005.1
AF249889 mRNA Translation: AAF98323.1
CCDSiCCDS18577.1 [Q9ET38-1]
CCDS18578.1 [Q9ET38-2]
RefSeqiNP_001033679.1, NM_001038590.1 [Q9ET38-1]
NP_694745.1, NM_153105.7 [Q9ET38-2]
UniGeneiMm.130701

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3X29X-ray3.70A/C1-185[»]
ProteinModelPortaliQ9ET38
SMRiQ9ET38
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-42881N
IntActiQ9ET38, 2 interactors
MINTiQ9ET38
STRINGi10090.ENSMUSP00000081334

PTM databases

PhosphoSitePlusiQ9ET38

Proteomic databases

PaxDbiQ9ET38
PRIDEiQ9ET38

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084309; ENSMUSP00000081334; ENSMUSG00000066058 [Q9ET38-1]
ENSMUST00000094823; ENSMUSP00000092418; ENSMUSG00000066058 [Q9ET38-2]
GeneIDi242653
KEGGimmu:242653
UCSCiuc008uls.1 mouse [Q9ET38-1]

Organism-specific databases

CTDi149461
MGIiMGI:3033992 Cldn19

Phylogenomic databases

eggNOGiENOG410IG5H Eukaryota
ENOG410Y143 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiQ9ET38
KOiK06087
OMAiARFEFGP
OrthoDBiEOG091G0MX2
PhylomeDBiQ9ET38
TreeFamiTF331936

Miscellaneous databases

PROiPR:Q9ET38
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066058 Expressed in 30 organ(s), highest expression level in sciatic nerve
CleanExiMM_CLDN19
ExpressionAtlasiQ9ET38 baseline and differential
GenevisibleiQ9ET38 MM

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD19_MOUSE
AccessioniPrimary (citable) accession number: Q9ET38
Secondary accession number(s): Q8R4B7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 24, 2004
Last modified: November 7, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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